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RecruitingNCT06365073Updated Apr 15, 2024

A Case-control Study on the Clinical Characteristics of 28-day and 90-day Death From Severe Anthrax

An observational study in Anthrax, sponsored by Qin Ning. Recruiting at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-04-15.

Sponsored by Qin Ning · Observational

From the registry’s dates

  • Primary completion was expected by Aug 2024, 2 years 2 months ago, but the record still lists the study as recruiting.
  • Started Mar 2024; still recruiting 2 years 7 months later.
Study type
Observational
Model
Case-control
Time perspective
Retrospective
Enrollment
80
Ages
18 Years and older
Sex
All
01

Study summary

This study is a clinical, multi-center, retrospective, case-control study. Patients clinically diagnosed with severe anthrax who meet the inclusion and exclusion criteria will be included in this study for analysis. Respiratory, circulation, nerve and other vital signs of patients with severe anthrax during hospitalization were recorded, and clinical data such as blood routine, blood biochemistry, coagulation function, myocardial injury, therapeutic drug use, and survival time of patients were recorded, as well as the survival situation of patients 28 days and 90 days after discharge.

02

Conditions studied

  • Anthrax

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03

In context

Anthrax

75 studies on the registry are indexed under Anthrax; 12 are open to participants now.

This study's planned enrollment of 80 is below the median of 99 across 16 observational studies indexed under Anthrax.

Browse Anthrax studies →

Lead sponsor

Qin Ning is the lead sponsor of 11 studies on the registry; 5 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

patients with severe anthrax

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  1. The typical bacilli with capsules were found in smear examination and culture of various secretions, excretions, blood and cerebrospinal fluid.
  2. Multiple organ dysfunction (MODS) in brain, heart, liver, kidney, coagulation or more than one organ failure.

Exclusion criteria

Exclusion Criteria:

There are other conditions that affect short-term survival.

05

Study design

Observational model
Case-control
Time perspective
Retrospective
Enrollment
80 participants (estimated)
Patient registry
No

Groups and cohorts

  • survival group

    Patients who survived in 28 days/90 days

  • death group

    Patients who survived in 28 days/90 days

06

What researchers measure

Primary outcomes

  1. mortality rates of severe anthrax

    mortality rates of severe anthrax

    Time frame: 28 days and 90 days

Secondary outcomes

  1. incidence of complications

    To evaluate the incidence of respiratory, circulatory, neurological, digestive, coagulation and other complications of severe anthrax

    Time frame: in hospital

  2. Peripheral blood biomarkers associated with 28-day and 90-day mortality

    Peripheral blood biomarkers associated with 28-day and 90-day mortality

    Time frame: 28 days and 90 days

  3. the improvement in 28-day and 90-day mortality with treatment for severe anthrax

    the improvement in 28-day and 90-day mortality with treatment for severe anthrax

    Time frame: 28 days and 90 days

07

Study locations

1 of 1 sites recruiting
  • Department of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
    Wuhan, Hubei, China
    Recruiting
    • Qin Ning, PHD,MD · Contactqning@vip.sina.com · +8602783662391
    • Qin Ning, PHD,MD · Principal investigator
    • Tao Chen, PHD,MD · Sub investigator
08

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Started Mar 2024 (actual). Primary completion is estimated for Aug 2024, 5 months after the start.

How these figures are worked out, and which studies are left out of them.

Registered
Apr 10, 2024
First posted
Apr 15, 2024
StartActual
Mar 13, 2024
Primary completionEst.
Aug 31, 2024
CompletionEst.
Dec 31, 2024
Last update
Apr 15, 2024
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Apr 15, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT06365073
Lead sponsor
Qin Ning
Responsible party
Qin Ning (Professor, Tongji Hospital) — Sponsor-investigator
First posted
Apr 15, 2024
Start date
Mar 13, 2024
Primary completion
Aug 31, 2024 (estimated)
Completion
Dec 31, 2024 (estimated)
Last update
Apr 15, 2024

Study contacts

Qin Ning, professor
Contact
qning@vip.sina.com
027-83665919

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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