An observational study in Brucellosis, sponsored by Qin Ning. Completed at 8 sites in China. Per ClinicalTrials.gov, last updated 2023-08-23.
Sponsored by Qin Ning · Observational
This is a multicenter, retrospective clinical study, in patients with brucellosis, to analyze the clinical characteristics, complications, and the impact of different treatment options on long-term prognosis of patients with brucellosis. All hospitalized patients diagnosed with brucellosis between 2016 and 2021 were included from the electronic medical record systems of eight centers, collecting demographics, hospitalization information, clinical information, laboratories, imaging studies, treatment regimens, and disease outcome and other information.
15 studies on the registry are indexed under Brucellosis; 6 are open to participants now.
Browse Brucellosis studies →Qin Ning is the lead sponsor of 11 studies on the registry; 5 are open to participants now.
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Hospitalized patients diagnosed with Brucellosis from 8 centers in Hubei Province, China.
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Specific reference to the People's Republic of China's health industry standard "Diagnosis for brucellosis" (WS269-2019) diagnosed as a patient with brucellosis, that is, the patient meets a suspected or clinically diagnosed case and passes the confirmatory test mentioned below at the same time Either to prove:
Exclusion Criteria:
Clinical characteristics
The electronic medical record system was used to collect patients' symptoms from baseline (admission) to 24 months, including initial symptoms, constitutional symptoms and signs \[fever (maximum temperature, duration), hyperhidrosis, muscle/joint soreness, fatigue, hepatomegaly, splenomegaly, testicular enlargement, oophoritis, lymphadenopathy (location and size), others\].
Time frame: 2 year
Complication rate
Electronic medical record system was used to collect the complications of patients from baseline (admission) to 24 months, and the incidence of complications within 2 years was calculated. Complications include osteoarticular system (sacroiliitis, spondylitis, peripheral arthritis, osteomyelitis, bone destruction, etc.) that may be related to brucellosis, Genitourinary system (orchitis, epididymitis, oophoritis, glomerulonephritis, renal abscess, etc.), central nervous system (peripheral neuropathy, meningoencephalitis, mental symptoms, cranial nerves, chorea, etc.), skin (maculopapular rash, Cyst, Stevens-Johnson syndrome, etc.), respiratory system (pleural effusion, pneumonia, etc.), blood system (leukocyte increase or decrease, platelet deficiency, etc.), cardiovascular system (endocarditis, vasculitis, myocarditis wait). Diagnostic tests for complications include laboratory tests (blood routine, etc.), echocardiography, imaging tests (X-ray, ultrasound, high-resolution CT)
Time frame: 2 year
Survival rate
The 1-year survival rate and 2-year survival rate were calculated.
Time frame: 1 year,2 years
Disease outcome (cured, improved, not cured, progress, relapse, death)
The electronic medical record system was used to collect the disease outcomes of patients from baseline (admission) to 24 months.
Time frame: 2 year
Etiological characteristics (B.melitensis [1, 2, 3 subtypes], B.abortus[1-9 subtypes], B.suis [1-5 subtypes], B.canis)
Etiologic characteristics were collected from baseline (admission) through 24 months with the use of an electronic medical record system. The distribution of pathogens was analyzed, and the relationship between different pathogenic characteristics and long-term prognosis (disease outcome) was evaluated.
Time frame: 2 year
Number of patients with severe brucellosis (ICU number)
The electronic medical record system was used to collect the proportion of patients admitted to ICU from baseline (admission) to 24 months, and the proportion of patients admitted to ICU was calculated.
Time frame: 2 year
antimicrobial therapy
The electronic medical record system was used to collect the treatment options of patients from baseline (admission) to 24 months, and the impact of different treatment options on prognosis (disease outcome) was evaluated.
Time frame: 2 year
Hospital costs
The electronic medical record system was used to collect the hospitalization expenses of patients, and the average hospitalization cost was calculated.
Time frame: 2 year
Ran from Apr 2022 to primary completion in Dec 2022, 8 months.
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This study is completed, as verified in Aug 2023. You cannot join it, but the record below documents what was studied.
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