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Active, not recruitingNCT06360562Updated May 11, 2026

Reconnecting to Ourselves and Others in Virtual Meetings (ROOM)

An interventional study of Resilience Training in Mood Disorders, Anxiety Disorders and Psychotic Disorders, sponsored by Massachusetts General Hospital. Active, not recruiting at 1 site in United States. Open to participants aged 14 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-05-11.

Sponsored by Massachusetts General Hospital · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Registered 2 years 11 months after the study started (first participant enrolled Sep 2020, registered Aug 2023).
Phase
Not applicable
Study type
Interventional
Enrollment
174
Allocation
Not applicable
Ages
14 Years and older
Sex
All
01

Study summary

This study aimed to determine the feasibility and acceptability of delivering Resilience Training in multi-user virtual reality.

02

Conditions studied

  • Mood Disorders
  • Anxiety Disorders
  • Psychotic Disorders
03

In context

Mood Disorders

584 studies on the registry are indexed under Mood Disorders; 117 are open to participants now.

This study's planned enrollment of 174 is above the median of 72 across 429 interventional studies indexed under Mood Disorders.

Browse Mood Disorders studies →

Lead sponsor

Massachusetts General Hospital is the lead sponsor of 2,536 studies on the registry; 446 are open to participants now.

Of its 214 completed or terminated interventional studies of FDA-regulated products, 161 (75%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
14 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes

Eligibility criteria

Inclusion criteria for college student participants:

  1. 18-30 years old
  2. Enrolled in an undergraduate program

Inclusion criteria for healthcare provider participants:

  1. At least 18 years old
  2. Employed in the healthcare field with some direct patient contact

Exclusion Criteria:

  1. Inability to provide informed consent
  2. Not proficient in English
  3. Acute symptoms of a psychiatric illness needing immediate care (such as acute psychotic symptoms, current suicidality, serious active alcohol or substance use, marked deterioration in functioning over the prior month) determined by self-report that necessitates close monitoring or inpatient or partial hospitalization.
  4. Enrolled in current psychotherapy with frequency of more than once per month
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Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
174 participants (estimated)

Study arms

  • Experimental
    Resilience Training

    A 6 1-hour session group based intervention to deliver mindfulness, metallization, and self-compassion.

    Behavioral: Resilience Training

Interventions

  • BehavioralResilience Training

    Behavioral group-based intervention delivering mindfulness, metallization, and self-compassion skills.

06

What researchers measure

Primary outcomes

  1. Discomfort with Others

    Discomfort with others is measured on a brief scale rated on a Likert scale of 1-5, asking three questions, how frequently someone feels discomfort with others, how intensely they feel it, and a multiple choice selection of reasons they may feel discomfort with others. Higher ratings indicate more discomfort with others.

    Time frame: Before the intervention, 6 weeks later, and 6 months later

  2. Intervention Feasibility and Acceptability

    This measure includes participant attendance, with more attendance of the intervention indicating better feasibility and acceptability.

    Time frame: Before the intervention, 6 weeks later, and 6 months later

  3. Penn Emotion Recognition Test

    The Penn Emotion Recognition Test (ER-40) is a 15-minute computer task which involves identifying the emotion (sadness, anger, etc.) expressed by a variety of face images with 5 possible options, was used to measure emotion recognition ability. The total score ranges from 0-40, with individual sub-scores for happy, sad, angry, fearful, and neutral expressions.

    Time frame: Before the intervention, 6 weeks later, and 6 months later

  4. Stop Distance Paradigm

    The Stop Distance Paradigm is a reliable way to measure ones personal space. The larger the number, the larger the person stands from others. This scale is rated by centimeters from zero (no personal space) to as many as the person chooses. This task was done in person, through Zoom, and in virtual reality.

    Time frame: Before the intervention, 6 weeks later, and 6 months later

Secondary outcomes

  1. Beck Depression Inventory

    The Beck Depression Inventory (BDI) is a 21-item self-report assessment obtaining ratings of one's level of depression on a Likert scale of 0-63, with higher scores indicating more depressive symptoms.

    Time frame: Before the intervention, 6 weeks later, and 6 months later

  2. Spielberger State-Trait Anxiety Inventory

    The Spielberger State-Trait Anxiety Inventory (STAI) is a 20-item self-report scale obtaining ratings of one's anxiety, both those that are trait like and ongoing, and those that are state like and temporary. Scores range from 0-120, with higher scores indicate higher levels of anxiety symptoms.

    Time frame: Before the intervention, 6 weeks later, and 6 months later

  3. Prodromal Questionnaire- Brief

    The Prodromal Questionnaire- Brief (PQ-B) is a 21-item self-report survey assessing psychotic experiences such as common delusional experiences (e.g. paranoia, grandiosity, ideas of reference) and perceptual aberrations (e.g. experiences of being controlled, mind reaching, etc.). and distress related to them. Each item is scored on a 0 to 5 scale. The total score is rated across the 21 items ranging between 0 and 105 with higher scores indicating more severe psychotic experiences.

    Time frame: Before the intervention, 6 weeks later, and 6 months later

  4. Connor-Davidson Resilience Scale

    The Connor-Davidson Resilience Scale (CD-RISC) is a 25-item self-report scale obtaining ratings of one's level of coping and emotional resilience. It is rated on a scale of 0-100, with higher scores indicate one has more coping skills and more emotional resilience.

    Time frame: Before the intervention, 6 weeks later, and 6 months later

07

Study locations

1 site
  • Massachusetts General Hospital
    Charlestown, Massachusetts 02129, United States
08

References and documents

Publications

  • Holt DJ, DeTore NR, Aideyan B, Utter L, Vinke L, Johnson DS, Zimmerman J, Dokholyan KN, Burke A. Enhancing social functioning using multi-user, immersive virtual reality. Sci Rep. 2025 Jan 22;15(1):2790. doi: 10.1038/s41598-024-84954-4. PubMed 39843493 ↗

Individual participant data

Plan to share: No — Data will be shared with investigator permission.

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 11, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT06360562
Lead sponsor
Massachusetts General Hospital
Responsible party
Daphne Holt (Associate Professor, Massachusetts General Hospital) — Principal investigator
First posted
Apr 11, 2024
Start date
Sep 15, 2020
Primary completion
Jan 30, 2025
Completion
Dec 31, 2028 (estimated)
Last update
May 11, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is active, not recruiting, as verified in May 2026. You cannot join it, but the record below documents what was studied.

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