An interventional study of Right Ventricular Outflow Tract Posterior Septum Pacing and systemic mapping and ablation in Ventricular Outflow Tract Ventricular Arrhythmias and Radio Frequency Catheter Ablation, sponsored by Second Affiliated Hospital of Wenzhou Medical University. Completed at 1 site in China. Open to participants aged 18 Years to 90 Years. Per ClinicalTrials.gov, last updated 2026-04-28.
Sponsored by Second Affiliated Hospital of Wenzhou Medical University · Not applicable, Interventional, and Treatment
The goal of this clinical trial is to make clear that a new method, right ventricular outflow tract (RVOT) posterior septum pacing, has a greater accuracy in predicting the origin of ventricular outflow tract (VOT) ventricular arrhythmias (VAs) compared to the previous electrocardiographic standards for the identification of the origin of ventricular outflow tract. The secondary aim is to investigate, by using the new method, if it can optimize the procedure of radiofrequency catheter ablation.
Researches will break the method of this investigation into two steps:
First step have enrolled 100 patients. This step would be used to compare the results predicted by right ventricular outflow tract posterior septum pacing, with the previously used electrocardiographic criteria and actual target site.
The second step will enroll another 100 patients. In this step, patients will be divided into two groups, one being the new protocol group and the other being the convention group. Patients will also be followed up, for 1 month and 3 months at outpatient clinic post procedure. Procedure time, success rate, fluoroscopy exposure time and complications, are compared between RVOT posterior septum pacing group and convention group.
Second Affiliated Hospital of Wenzhou Medical University is the lead sponsor of 133 studies on the registry; 44 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Procedure: Right Ventricular Outflow Tract Posterior Septum Pacing
Procedure: systemic mapping and ablation
The Right Ventricular Outflow Tract (RVOT) posterior septum pacing is routinely performed to observe the QRS complex characteristics of the 12 lead ECG (with a focus on comparing their differences with the R-wave amplitude of spontaneous ventricular arrhythmias in the right chest (V1\~V3) leads). When the pacing-induced R-wave amplitudes are all lower than spontaneous VAs in V1\~V3, we predict the origin of Left Ventricular Outflow Tract (LVOT), mapping and ablation in LVOT; otherwise we predict the origin of RVOT, mapping and ablation in RVOT.If fails, go to the opposite site to do mapping and ablation. If still fails, go to distal great cardiac vein (DGCV) to do mapping and ablation.
The TC or ST ablation catheter is delivered to ventricular outflow tract (VOT) to perform systemic mapping and ablation.
Rate of Immediate Ablation Success
Immediate Ablation Success is determined by the disappearance of ventricular arrhythmia after ablation, that cannot be induced by electrical stimulation and intravenous infusion of isoproterenol.
Time frame: At the end of the first procedure
Rate of Ablation Complication
Complications like cardiac tamponade, artery damage
Time frame: At the end of the first procedure
Accuracy of RVOT posterior septal pacing protocol
Target site predicted by RVOT posterior septal pacing protocol compared with actual target site and previous ecg criteria
Time frame: At the end of the first procedure
Incidence of Complications Post-operative
Complications like cardiac tamponade, artery damage
Time frame: period of post-operative to hospital discharge, within 7 days
Incidence of Complication
Complications like pericardial effusion, pseudo arterial aneurysm
Time frame: 1 months after first procedure
Rate of Recurrence during Follow up
Recurrence of the ventricular arrhythmia during the follow up period after catheter ablation procedure
Time frame: 1 months after first procedure
Incidence of Complication
Complications like pericardial effusion, pseudo arterial aneurysm
Time frame: 3 months after first procedure
Rate of Recurrence during Follow up
Recurrence of the ventricular arrhythmia during the follow up period after catheter ablation procedure
Time frame: 3 months after first procedure
This study is completed, as verified in Apr 2026. You cannot join it, but the record below documents what was studied.
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Second Affiliated Hospital of Wenzhou Medical University