An observational study in Sensorineural Hearing Loss, Bilateral, sponsored by Sensorion. Terminated at 2 sites in 2 countries. Open to participants aged 30 Years to 55 Years. Per ClinicalTrials.gov, last updated 2026-10-26.
Sponsored by Sensorion · Observational
Sponsor decision
The purpose of this study is to characterize and assess the evolution of hearing impairment of patients with adulthood-onset bilateral sensorineural hearing loss carrying mutations on GJB2 gene.
This study aims to characterize patients with adulthood-onset bilateral sensorineural hearing loss not due to any underlying medical condition (likely due to a genetic cause) and to assess the evolution of hearing impairment of those carrying mutations in GJB2 gene.
Patients who present with adulthood-onset bilateral sensorineural hearing loss will be screened for the presence of mutation involved in hearing impairment. Patients with GJB2 mutations will be proposed to continue in a follow-up period.
66 studies on the registry are indexed under Presbycusis; 21 are open to participants now.
This study's enrollment of 134 is close to the median of 123 across 20 observational studies indexed under Presbycusis.
Browse Presbycusis studies →Sensorion is the lead sponsor of 7 studies on the registry; 1 is open to participants now.
Compared within Presbycusis, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Hearing Loss, Sensorineural. The counts are of registry records indexed under each term, refreshed daily. How we classify →
Male and female participants aged ≥30 and ≤55 years old with bilateral hearing loss first noticed after the age of 16 years old.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Genetic: Genotyping
Other: Audiological assessments
Genotyping to determine if patients present mutations to the gene GJB2.
Audiological assessments
Evolution of hearing impairment of adult patients with early-onset presbycusis carrying mutations in GJB2 gene.
Evolution of hearing impairment assessed by Pure Tone Audiometry
Time frame: 2 years
Evolution of hearing impairment of adult patients with early-onset presbycusis carrying mutations in GJB2 gene
Evolution of hearing impairment assessed by Speech in noise
Time frame: 2 years
Genetic characteristics of adult patients with early-onset presbycusis
Genotyping
Time frame: Unique visit
Audiological characteristics of adult patients with early-onset presbycusis
Pure Tone Audiometry
Time frame: Unique visit
Mood evaluation in adult patients with early-onset presbycusis carrying mutations in GJB2 gene
Mood evaluation assessed with Patient Health Questionnaire for depression (PHQ-9)
Time frame: 2 years
Plan to share: No
No publications or documents are linked to this record.
Sponsor decision
Sponsor decision
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is terminated, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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Sensorion