An interventional study of punching closure and Conventional clipping in the Rate of Complete Closure, sponsored by Ningbo No. 1 Hospital. Recruiting at 1 site in China. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2024-04-05.
Sponsored by Ningbo No. 1 Hospital · Not applicable, Interventional, and Treatment
Endoscopic submucosal dissection (ESD) is an important minimally invasive treatment method for early digestive tract tumors, with a high cure rate, and it is widely used in clinical practice. And wound closure after ESD is a great challenge, which is closely related to postoperative perforation bleeding. Clip closure is one of the most commonly used closure methods. However, when the wound is large or when the wound is located more difficult to operate, conventional closure may lead to delayed perforation, and postoperative clips may be prone to early spontaneous shedding. The authors have recently reported a method that may be able to close larger and difficult wounds because the grooves can better fix the metal clips. The latest study suggests that this approach may be safe and effective, but the study has a small sample size and has no controls. Therefore, high-quality clinical study evidence related to punch closure is required in the strategy of defect closure after ESD, in order to better evaluate the feasibility and safety of this new endoscopic closure method.
Ningbo No. 1 Hospital is the lead sponsor of 56 studies on the registry; 12 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
punching closure for defect closure after ESD
Other: punching closure
Conventional clipping for defect closure after ESD
Other: Conventional clipping
The hole clamping and the grooves hold the metal clips better
Metal lip closure is one of the most commonly used closure methods
Completely closed
The wound is completely closed without dehiscence
Time frame: 4 weeks
delayed hemorrhage
Any symptoms of gastrointestinal bleeding (e. g. hematochezia) occurred within 30 days after polypectomy and were classified as mild or severe according on the severity of the bleeding
Time frame: 2 weeks and 4 weeks
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Ningbo No. 1 Hospital