An interventional study of underwater endoscopic mucosal resection and hot snare polypectomy in Pedunculated Colorectal Polyps and Haemorrhage, sponsored by Ningbo No. 1 Hospital. Recruiting at 1 site in China. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2024-12-18.
Sponsored by Ningbo No. 1 Hospital · Not applicable, Interventional, and Treatment
Endoscopic resection of pedunculated polyps mainly focuses on how to prevent bleeding, and also needs to pay attention to the convenience of resection and the integrity of resection, which means that different endoscopic resection strategies should be adopted for pedunculated polyps with different pedicle sizes. The head larger than 20mm or pedicle larger than 5mm are defined as large pedunculated polyps, which are at greater risk of bleeding. Current guidelines recommend hot removal by snare following preoperative saline injection, ligation of the pedicle with a nylon ring or metal clip, depending on the size of the polyp head and pedicle. However, the use of snares and metal clamps does not appear to reduce delayed postoperative bleeding, and the technical requirements of nylon ligation are relatively high. Recent studies have found that Underwater endoscopic mucosal resection (UEMR) is also safe and effective for the treatment of large and medium colorectal sessile polyps. Therefore, it is still necessary to further explore new safe and effective endoscopic resection strategies and techniques.
1,383 studies on the registry are indexed under Hemorrhage; 244 are open to participants now.
This study's planned enrollment of 156 is above the median of 102 across 926 interventional studies indexed under Hemorrhage.
Browse Hemorrhage studies →Ningbo No. 1 Hospital is the lead sponsor of 59 studies on the registry; 12 are open to participants now.
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Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
underwater endoscopic mucosal resection for resection of big pedunculated colorectal polyps
Other: underwater endoscopic mucosal resection
hot snare polypectomy for resection of big pedunculated colorectal polyps
Other: hot snare polypectomy
underwater endoscopic mucosal resection achieves similar rates of complete resection with comparable safety, with lower rates of recurrence and fewer repeat procedures.
Current guidelines recommend preoperative hot snare polypectomy after preoperative saline injection, nylon ring, or metal clip ligation of the tip and pedicle of the polyps
Prevalence of immediate bleeding
Immediate bleeding was defined as an intraoperative bleeding immediately after Immediate bleeding staging: If there is no bleeding, fill in 'none'; Level 1, spontaneous hemostasis within 60 seconds; Level 2, continuous small bleeding for more than 60 seconds; Level 3, continuous bleeding for more than 60 seconds requires endoscopic treatment; Level 4, arterial spray
Time frame: 1 Minutes
delayed hemorrhage
Any symptoms of gastrointestinal bleeding (e. g. hematochezia) occurred within 30 days after polypectomy and were classified as mild or severe according on the severity of the bleeding
Time frame: 2 weeks and 4 weeks
Immediate perforation rate
perforation
Time frame: 30 seconds
Started Oct 2023 (actual). Primary completion is estimated for Aug 2026, 34 months after the start.
Of 191 non-industry interventional studies with no phase under Hemorrhage, half reached primary completion within 19 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 37. This study's planned 34 months is above that.
Counting every sponsor, half of 226 studies reached it within 19 months; a quarter within 9 and three quarters within 35.
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Ningbo No. 1 Hospital