An interventional study of LED and without any LED exposition in Hyperpigmentation, sponsored by Yanjun Dan. Status unknown at 1 site in China. Open to participants aged 20 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-04-05.
Sponsored by Yanjun Dan · Not applicable, Interventional, and Treatment
The aim of this study is to explore the effect of medical LEDs (830 nm and 590 nm) in the prevention and treatment of PIE and PIH.
Evidence regarding the efficacy of LEDs for post-inflammatory erythema (PIE) and post-inflammatory hyperpigmentation (PIH) is limited.
The aim of this study was to evaluate the efficacy of 830 nm and 590 nm LED phototherapies on PIE and PIH.
Design of the study:
308 nm LED light (1.5 MED) induced an in vivo PIE/PIH model on the thigh of ten healthy subjects. 830 nm (60 J/cm2) and 590 nm LED (20 J/cm2) were irradiated respectively. For therapeutic irradiation, PIE/PIH model was induced on D1, and LEDs were irradiated on D0, 1, 3, 6 and 8. For preventive irradiation, LEDs were irradiated on D0, 1, 3, 6 and 8 and PIE/PIH model was induced on D9. Erythema index (EI), melanin index (MI), transdermal water loss (TEWL) and C-Cube photography were measured during 10-day follow-up visits.
106 studies on the registry are indexed under Hyperpigmentation; 20 are open to participants now.
This study's planned enrollment of 10 is below the median of 35 across 93 interventional studies indexed under Hyperpigmentation.
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Exclusion Criteria:
For therapeutic irradiation, the PIH model was induced on D1, and 830 nm (60 J/cm2, 50 mW/cm2) and 590 nm LED (20 J/cm2, 20 mW/cm2) were irradiated on D0, D1, D3, D6 and D8, respectively. For preventive irradiation, 830 nm and 590 nm LED were irradiated on D0, D1, D3, D6 and D8, respectively, and the PIE/PIH model was induced on D9.
Device: LED
the PIH model was induced on D1 and without any LED exposition.
Other: without any LED exposition
308 nm LED light was utilized to induce an vivo PIE/PIH model on the thigh of subjects. The irradiation dose was 1.5 MED. Five circular experimental lesions measuring 1.5 × 1.5 cm were selected on the thighs, categorizing into five groups: control group, 830 nm LED treatment group, 590 nm LED treatment group, 830 nm LED prevention group and 590 nm LED prevention group. 830 nm LED and 590 nm LED were irradiated, respectively. For therapeutic irradiation, the PIH model was induced on D1, and 830 nm (60 J/cm2, 50 mW/cm2) and 590 nm LED (20 J/cm2, 20 mW/cm2) were irradiated on D0, D1, D3, D6 and D8, respectively. For preventive irradiation, 830 nm and 590 nm LED were irradiated on D0, D1, D3, D6 and D8, respectively, and the PIE/PIH model was induced on D9.
without any LED exposition
melanin index
The effect of LED treatment on PIH will be estimated by measure by C-CUBE.
Time frame: at day 8
erythema index
The effect of LED treatment on PIE will be estimated by measure by C-CUBE.
Time frame: at day 8
transepidermal water loss (TEWL)
The effect of LED treatment on skin water loss will be estimated by measure by delfin.
Time frame: at day 8
elasticity
The effect of LED treatment on skin elasticity will be estimated by measure by delfin.
Time frame: at day 8
Plan to share: No
No publications or documents are linked to this record.
This study is status unknown, as verified in Apr 2024. You cannot join it, but the record below documents what was studied.
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