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TerminatedNCT06346704NHS-MS-EGYPTUpdated Dec 15, 2025

Prospective Longitudinal Monocentric Study to Evaluate the Syde® Digital Endpoint in Patients With Multiple Sclerosis

An observational study in Multiple Sclerosis, sponsored by SYSNAV. Terminated at 1 site in Egypt. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2025-12-15.

Sponsored by SYSNAV · Observational

Why this study was terminated
Sponsor's decision
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
86
Ages
18 Years to 65 Years
Sex
All
01

Study summary

The study aims to assess the validity of real-world activity monitoring by the Syde® wearable device in subjects with multiple slclerosis. The Syde® collected data will be compared to on-site conventional clinical endpoints for MS pathology (EDSS, FSS and T25FWT). Subjects with multiple sclerosis will be assessed every 6 months for 2 years.

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Conditions studied

  • Multiple Sclerosis

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Keywords

  • Digital Health Technology
03

In context

Multiple Sclerosis

3,460 studies on the registry are indexed under Multiple Sclerosis; 661 are open to participants now.

This study's enrollment of 86 is below the median of 100 across 1,016 observational studies indexed under Multiple Sclerosis.

Browse Multiple Sclerosis studies →

Lead sponsor

SYSNAV is the lead sponsor of 5 studies on the registry; 3 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Sampling method
Non-probability sample

Study population

Subjects followed for multiple sclerosis care at the investigational site.

Inclusion criteria

  1. Male or female subject aged from 18 to 65 years old.
  2. Signed informed consent and ability to comply with study and follow-up.
  3. Diagnosed with MS base on 2017 McDonald criterion
  4. EDSS ≤ 5.5
  5. No clinical or radiological relapse within the last 3 months
  6. For patient under treatment, the molecule and its dose should be stable about 2 months before inclusion
  7. Subject willing and able to comply to all study procedures including the Syde® related ones

Exclusion criteria

Exclusion Criteria:

  1. Patient with a cognitive or communicational disorder disturbing the understanding of the tasks or data collection
  2. Previous or current disorder with an impact on current ambulation or motor function
  3. Patient who have had surgery or traumatic injury in upper or lower limb within the last 6 months before the inclusion or patients who have had major surgery or trauma within the last 6 months before the inclusion
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
86 participants (actual)
Patient registry
No

Interventions

  • OtherDigital HealthTechnology

    Subject will wear the Syde® for 1 month every 6 months

    Also known as: Syde®

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What researchers measure

Primary outcomes

  1. Longitudinal change of 95th centile of stride velocity

    change between baseline and Month 6, Month 12, Month 18 and Month 24

    Time frame: 2 years

Secondary outcomes

  1. Correlation of the Syde® variables with the clinical assessments EDSS, FSS and T25FWT

    Time frame: 2 years

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Study locations

1 site
  • Air Force Specialized Hospital
    Cairo, Egypt
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 15, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT06346704
Lead sponsor
SYSNAV
Responsible party
Sponsor
First posted
Apr 4, 2024
Start date
Apr 25, 2024
Primary completion
Apr 25, 2025
Completion
Apr 25, 2025
Last update
Dec 15, 2025

Study contacts

Ahmed Elnemr, MD
principal investigator · Air Force Specialized Hospital Cairo

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is terminated, as verified in Oct 2025. You cannot join it, but the record below documents what was studied.

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