An observational study in Uveitis, sponsored by Meyer Children's Hospital IRCCS. Recruiting at 19 sites in 5 countries. Open to participants aged 1 Year to 16 Years. Per ClinicalTrials.gov, last updated 2026-03-27.
Sponsored by Meyer Children's Hospital IRCCS · Observational
Uveitis is an inflammatory disease of the uvea, one of the highly vascularized fundamental structures of the eye. It is a rare condition in children, with an incidence in the pediatric population ranging from 2% to 14% of all uveitis cases. The diagnosis and management of patients with uveitis rely on a multidisciplinary approach involving an ophthalmologist, a rheumatologist, and an infectious disease specialist to establish the correct diagnosis and assess the involvement of other organs. In Italy, there is no national or regional registry for non-infectious chronic uveitis as per the Prime Ministerial Decree (DPCM) of March 3, 2017 (Identification of surveillance systems and registries for mortality, tumors, and other diseases). However, many clinical centers adopt data recording systems to evaluate the quality of care and to study diseases and outcomes. The Universitary Hospital Meyer Institute Research Hospital (IRCCS) is a national referral center for managing these pediatric cases of non-infectious chronic uveitis, estimated to constitute 95% of all pediatric uveitis cases
The data of patients who have been under the care of the hospital since 2010 will be included, and new patients diagnosed from the date of Ethical Committee approval onwards for the next 10 years will also be included
Exclusion Criteria:
Describe a population of paediatric patients with chronic non-infectious uveitis
* Frequency of each aetiology of uveitis * Frequency of signs and symptoms at onset of uveitis * Frequency of laboratory findings * Frequency of each anatomical subtype of uveitis
Time frame: thorugh the study and after 1 year
Describe a population of paediatric patients with chronic non-infectious uveitis
* Frequency of complications at onset, 6 months, 12 months, 2 years, then every year * Frequency of impaired visual acuity (LogMAR0.4-1) and blindness (LogMAR\>=1) at onset and at different time points (6 months, 12 months, 18 months, 2 years, then every year)
Time frame: 6 months, 12 months, 2 years and then every year
Identify any differences between the different forms of uveitis in terms of characteristics and outcomes
* Frequency of complications and impaired visual acuity * Description of laboratory characteristics
Time frame: thorugh the study and after 1 year
Identify risk factors for a more severe course
Percentages of children with impaired visual acuity * Percentages of children with ocular complications
Time frame: thorugh the study and after 1 year
Frequency achievement of response for each drug according to the definition of response
Frequency achievement of response for each drug according to the definition of response of the MIWGUC group
Time frame: thorugh the study and after 1 year
Time to archieve the response after drug initiation
Time to archieve the response after drug initiation
Time frame: thorugh the study and after 1 year
Achievement of inactive disease on therapy according to the definition of MIWGUC
Achievement of inactive disease on therapy according to the definition of MIWGUC
Time frame: thorugh the study and after 1 year
Time to achieve inactive disease on therapy according to the definition of MIWGUC
Time to achieve inactive disease on therapy according to the definition of MIWGUC
Time frame: thorugh the study and after 1 year
Presence and percentages of flares on therapy after achievement of remission on therapy
Presence and percentages of flares on therapy after achievement of remission on therapy
Time frame: thorugh the study and after 1 year
Time to the first flare on therapy
Time to the first flare on therapy
Time frame: thorugh the study and after 1 year
Time to flare after drug withdrawal
Time to flare after drug withdrawal * Proportion of Flare after drug withdrawal in general at the last available follow-up * Proportion of children who flared after drug withdrawal at 6, 12 and 18 months, 2 years then every year
Time frame: 6, 12 and 18 months, 2 years then every year
Plan to share: No
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Meyer Children's Hospital IRCCS