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Not yet recruitingNCT06270004Updated Feb 21, 2024

Effect of Nonsurgical Periodontal Therapy on Salivary Biomarkers Related to Bone Turnover in Smoker and Nonsmoker Periodontitis Patients

An interventional study of nonsurgical periodontal therapy in Non Surgical Periodontal Therapy, sponsored by University of Baghdad. Not yet recruiting. Per ClinicalTrials.gov, last updated 2024-02-21.

Sponsored by University of Baghdad · Not applicable, Interventional, and Other

From the registry’s dates

  • Primary completion was expected by Nov 2024, 1 year 11 months ago, but the record still lists the study as not yet recruiting.
Phase
Not applicable
Study type
Interventional
Enrollment
30
Allocation
Non-randomized
Sex
All
01

Study summary

  1. To assess the alteration in the level of salivary osteopontin (OPN), osteonectin(ON) and histatin-1 following NSPT in smoker and nonsmoker unstable periodontitis patients at different time intervals(one month and three months) .
  2. To evaluate the response of clinical periodontal parameters ( plaque index ,bleeding on probing ,probing pocket depth ,clinical attachment loss)following NSPT in smoker and nonsmoker unstable periodontitis patients at different time intervals (one month and three months)
Read the detailed description

the study include nonsurgical periodontal therapy for smoker and non smoker patients with unstable periodontitis and evaluate the clinical periodontal parameters ( plaque index, bleeding on probing , probing pocket depth ,clinical attachment loss) and assess the alteration in the level of salivary osteopontin (OPN), osteonectin(ON) and histatin-1 following NSPT in smoker and nonsmoker unstable periodontitis patients at different time intervals(one month and three months)

02

Conditions studied

  • Non Surgical Periodontal Therapy

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Keywords

  • osteonectin
  • osteopontin
  • histatin1
03

In context

Periodontitis

1,635 studies on the registry are indexed under Periodontitis; 327 are open to participants now.

This study's planned enrollment of 30 is below the median of 45 across 1,191 interventional studies indexed under Periodontitis.

Browse Periodontitis studies →

Lead sponsor

University of Baghdad is the lead sponsor of 164 studies on the registry; 66 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • participants will be systemically healthy without history of any systemic diseases.
  • hadn't underwent periodontal treatment during the previous 6 months and not taken medication during the previous 3 months.
  • present with at least 20 teeth, those who only diagnosed with 4-6 mm probing pocket depth, generalized ,unstable periodontitis who had bone loss > 30% , probing probing pocket depth at ≥4mm . Periodontitis cases were defined if clinical attachment loss was detected at ≥2 non- adjacent teeth or when buccal (facial) showed clinical attachment loss ≥3mm associated with probing pocket depth >3mm at ≥ 2 teeth .
  • The patients in the smokers group will be current smokers ( cigarette smokers) with smoking habit for over 3 years

Exclusion criteria

Exclusion Criteria:

  • Subjects have any intraoral plaque retentive factors such as those wearing partial denture, crown and bridges, and orthodontic appliances ,furcation involved teeth, overhang filling, tooth anomaly.
  • receiving antibiotic therapy during the previous 3 months.
  • those with systemic diseases such as diabetes mellitus, cardiovascular or renal diseases, etc...., pregnant or lactating women, not willing to participate or continue to conduct the study.
05

Study design

Phase
Not applicable
Primary purpose
Other
Allocation
Non-randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
30 participants (estimated)

Study arms

  • Active comparator
    nonsmoker periodontitis patients

    Other: nonsurgical periodontal therapy

  • Active comparator
    smoker periodontitis patients

    cigarette smoker more the three years ago

    Other: nonsurgical periodontal therapy

Interventions

  • Othernonsurgical periodontal therapy

    sonic scaler for scaling and polishing. Graces curettes numbers(1-2,3-4,5-6,7-8,9-10,11-12,13-14)for root surfaces debridement(RSD), instructions and motivation for dental arch

06

What researchers measure

Primary outcomes

  1. Effect of nonsurgical periodontal therapy(NSPT) on salivary biomarkers related to bone turnover in smoker and nonsmoker periodontitis patients.

    salivary concentration of osteopontin between smoker and nonsmoker unstable periodontitis patients following NSPT at different time intervals.

    Time frame: baseline, one month and three months

Secondary outcomes

  1. Effect of nonsurgical periodontal therapy(NSPT) on salivary biomarkers related to bone turnover in smoker and nonsmoker periodontitis patients.

    salivary concentration of osteonectin between smoker and nonsmoker unstable periodontitis patients following NSPT at different time intervals .

    Time frame: baseline, one month and three months

  2. Effect of nonsurgical periodontal therapy(NSPT) on salivary biomarkers related to bone turnover in smoker and nonsmoker periodontitis patients

    salivary concentration of histatin1 between smoker and nonsmoker unstable periodontitis patients following NSPT at different time intervals.

    Time frame: baseline, one month and three months

07

Study locations

No study locations are listed for this record.

08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 21, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06270004
Lead sponsor
University of Baghdad
Responsible party
Aqeel Ali (Iraq ,baghdad, University of Baghdad) — Principal investigator
First posted
Feb 21, 2024
Start date
Mar 1, 2024 (estimated)
Primary completion
Nov 1, 2024 (estimated)
Completion
Dec 1, 2024 (estimated)
Last update
Feb 21, 2024

Study contacts

Aqeel Ali, baccalaureus
Contact
aqeel.ali2205@codental.uobaghdad.edu.iq
+96407705518935
Maha shukri, master
Contact
mahashukri@codental.uobaghdad.edu.iq
+96407716249206

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Feb 2024. You cannot join it, but the record below documents what was studied.

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Discussion

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