An interventional study of Experiment 1: visual and auditory attention task and Experiment 2: language production and rest tasks in Mild Concussion and Healthy Volunteers, sponsored by Hospices Civils de Lyon. Recruiting at 2 sites in France. Open to participants aged 18 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-06-01.
Sponsored by Hospices Civils de Lyon · Not applicable, Interventional, and Other
Among 27 studies in Brain Concussion with a site in France — 8 open to participants now, 9 under way, none of them phase 3. Brain Concussion · France.
Among the 27 studies in Brain Concussion with a site in France, this one is the 7th largest by planned enrollment of the 12 interventional ones that give a count, is one of 4 that started in 2025, is one of 12 with no phase, and was the 21st registered.
639 studies on the registry are indexed under Brain Concussion; 165 are open to participants now.
Browse Brain Concussion studies →8 of the 27 studies in Brain Concussion with a site in France are open now. Recruiting first, the newest first:
Centre Mutualiste de Rééducation et de Réadaptation Fonctionnelles de Kerpape · Sites in France
Ages 16+ · Men only · Healthy volunteers
Assistance Publique Hopitaux De Marseille · Sites in France
Ages 18–90 · Healthy volunteers
Sys2Diag · Sites in France
Ages 19–20 · Men only · Healthy volunteers
University Hospital, Bordeaux · Sites in France
Ages 18+
Sys2Diag · Sites in France
Ages 18–50 · Men only · Healthy volunteers
A study can be open while its sites in France have not opened yet or have stopped. Only those recruiting at a site in France →
Of the 112 Brain Concussion studies recruiting now, 33 (29%) set no upper age limit and 72 (64%) stop at 75 or younger; 24 take children under 18; 38 take healthy volunteers.
This study: 18 Years to 70 Years · all sexes · healthy volunteers too.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
27 studies; the count open now beside each. This study's row is marked.
First in 2012; this study’s year is marked. 4 started in 2025.
This study's planned enrollment of 80 is above the median of 63 across 447 interventional studies indexed under Brain Concussion.
Median enrollment 85 across the 12 interventional studies, 560 across the 15 observational. Of the 14 that completed or were terminated, 1 (7%) have results posted.
This tab as a report to print or save as PDF → With an account.
1 of 27 have an industry lead sponsor. The 10 most frequent:
Hospices Civils de Lyon is the lead sponsor of 1,867 studies on the registry; 448 are open to participants now.
Hospices Civils de Lyon has 1 study filed under Brain Concussion — fewer than ten, so there is no comparison to draw.
4 of the studies in Brain Concussion with a site in France that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07507253Sys2DiagPilot Study on the Correlation Between Accelerations Experienced | 2027-01-21 |
| NCT07931066University Hospital, GrenobleThe Use of GFAP and UCH-L1 Biomarkers in Clinical Practice for the Management of Mild Traumatic Brain Injury | 2027-03-05 |
| NCT05719844University Hospital, Clermont-FerrandInterest of an Attentional Evaluation by a Computerized Battery in the Management of Concussion in Young Rugby Players | 2027-03-09 |
| NCT06244472Hospices Civils de LyonA New Generation of Magnetoencephalographs for High Speed Functional Brain Imaging | 2027-08 |
Add all 4 to your calendar (.ics) → With an account.
Among the 27 studies in Brain Concussion with a site in France, from their registry updates:
This tab as a report to print or save as PDF → With an account.
The goal is to perform a first evaluation of the capabilities of a new generation of non-invasive magnetoencephalography whole head device using optically pumped magnetometers using Helium 4 as the sensitive element (OPM He4) to record brain magnetic activities. The investigators will record 1) healthy subjects stimulated with visual, auditory, somesthesic and motor stimuli and 2) athletes who suffered a mild concussion. The main hypothesis is that the OPM magnetoencephalographs (MEG) system will be able to detect brain activity. The secondary hypothesis is that the data recorded with the OPM MEG system will allow to reconstruct maps of the brain activity. To test the main hypothesis, they will compare the signal to noise ratio of brain activities between a classical MEG system and the new OPM He4 MEG. The secondary hypothesis will be tested through a comparison of the maps of brain activity obtained thanks to the data recorded with a classical MEG system and the new OPM He4 MEG.
Healthy volunteers:
Inclusion Criteria:
Exclusion Criteria:
Subject with common to MEG and MRI examination :
Subjects who suffered a mild concussion:
Inclusion Criteria:
Exclusion Criteria:
Subject with common contraindications to MEG and MRI examination :
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Healthy volunteers aged between 18 and 70 years, without neurological or psychiatric or sleep disorders
Device: Experiment 1: visual and auditory attention task · Device: Experiment 2: language production and rest tasks · Device: Experiment 3: visuo-motor task
Male athletes volunteers with concussion aged between 18 and 40 years, without neurological or psychiatric or sleep disorders other than cerebral concussion.
Device: Experiment 4: brain activity at rest
We will use the FYNA Research system on 20 healthy volunteers with a visual and auditory attention task to evaluate the system's performance in recording brain signals complex frequency content.
We will use the FYNA Research system on 20 healthy healthy volunteers with a language production task to assess the system's functional mapping capabilities and a resting task to assess the system's ability to identify resting networks.
We will use the FYNA Research system in 20 healthy volunteers with a visuo-motor task to evaluate the system's performance in recording brain signals when the subject moves, inducing perturbations that affect the classical system (loss of spatial precision) and the FYNA Research system (low-frequency artifacts).
We will be using the FYNA Research system on 20 concussed male athletes volunteers to assess the system's ability to detect modulations in the frequency content of resting brain activity.
Signal to Noise Ratio comparison between classical MEG and FYNA Research for the visual stimulations
The signal to noise ratio of normal (SNR) brain activity following a visual stimulus will be computed with respect to the pre-stimulus baseline -100 milliseconds to -10 milliseconds. We will compare the SNRs obtained with the classical MEG system serving as a reference and the SNRs obtained with the new OPM He4 MEG through the group of healthy volunteers for this given stimulus.
Time frame: Visit 2 (during the intervention, scheduled from 1 to 30 days from inclusion visit V1).
Signal to Noise Ratio comparison between classical MEG and FYNA Research for the auditory stimulations
The signal to noise ratio of normal (SNR) brain activity following an auditory stimulus will be computed with respect to the pre-stimulus baseline -100 milliseconds to -10 milliseconds . We will compare the SNRs obtained with the classical MEG system serving as a reference and the SNRs obtained with the new OPM He4 MEG through the group of healthy volunteers for this given stimulus.
Time frame: Visit 2 (during the intervention, scheduled from 1 to 30 days from inclusion visit V1).
Signal to Noise Ratio comparison between classical MEG and FYNA Research for the somesthesia stimulations
The signal to noise ratio of normal (SNR) brain activity following a somesthetic stimulus will be computed with respect to the pre-stimulus baseline -100 milliseconds to -10 milliseconds . We will compare the SNRs obtained with the classical MEG system serving as a reference and the SNRs obtained with the new OPM He4 MEG through the group of healthy volunteers for this given stimulus.
Time frame: Visit 2 (during the intervention, scheduled from 1 to 30 days from inclusion visit V1).
Signal to Noise Ratio comparison between classical MEG and FYNA Research for the motor stimulations
The signal to noise ratio of normal (SNR) brain activity following a motor stimulus will be computed with respect to the pre-stimulus baseline -100 milliseconds to -10 milliseconds . We will compare the SNRs obtained with the classical MEG system serving as a reference and the SNRs obtained with the new OPM He4 MEG through the group of healthy volunteers for this given stimulus.
Time frame: Visit 2 (during the intervention, scheduled from 1 to 30 days from inclusion visit V1).
Signal to Noise Ratio comparison between classical MEG and FYNA Research for the rest activity
The signal to noise ratio of normal (SNR) brain activity at rest will be computed with respect to the pre-stimulus baseline -100 milliseconds to -10 milliseconds . We will compare the SNRs obtained with the classical MEG system serving as a reference and the SNRs obtained with the new OPM He4 MEG through the group of male athletes with concussion.
Time frame: Visit 2 (during the intervention, scheduled from 1 to 30 days from inclusion visit V1).
Correlation of maps of brain activity
We will report the spatial correlation between the maps computed with the classical MEG system and the ones computed with the new OPM He4 MEG. The classical MEG will serve as a reference. Healthy volunteers solely.
Time frame: Visit 2 (during the intervention, scheduled from 1 to 30 days from inclusion visit V1).
Evaluation of the comfort of the subject during the optically pumped magnetometers (OPM) He4 MEG recordings through a short verbal questionnaire (scores of the absolute and relative comfort scales).
The evaluation will be done verbally through a short questionnaire. This questionnaire evaluates the overall comfort of the OPM system with two questions: 1) An evaluation of the overall comfort thanks to a scale with five steps from very uncomfortable to very comfortable and 2) A comparison with the classical MEG system thanks to a 5 steps scale from much less comfortable than the classical MEG system to much more comfortable.
Time frame: 5 minutes after the end the recording session
Started Jul 2025 (actual). Primary completion is estimated for Aug 2027, 25 months after the start.
Of 248 non-industry interventional studies with no phase under Brain Concussion, half reached primary completion within 28 months of starting (the median), counting those still running; a quarter within 19 and three quarters within 47. This study's planned 25 months is below that.
Counting every sponsor, half of 264 studies reached it within 28 months; a quarter within 19 and three quarters within 47.
How these figures are worked out, and which studies are left out of them.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.