An observational study in Peutz-Jeghers Syndrome, sponsored by Haramaya Unversity. Completed at 1 site in Ethiopia. Open to male participants, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-02-06.
Sponsored by Haramaya Unversity · Observational
Our study is a case report of one of the rarest risk factor, Peutz-Jeghers syndrome, of small bowel malignancy detected in a patient with poorly differentiated adenocarcinoma of small bowel(jejunum)
Case presentation: A 25-year-old male patient presented to the emergency department with generalized peritonitis caused by a perforated jejunal mass. The patient underwent an emergency exploratory laparotomy. There was 800 ml of thin pus in the peritoneal cavity and 5 cm by 6 cm perforated mass over the jejunum, 30cm from the ligament of the treitz, which extends to the mesentery. Palpable jejunal mesenteric lymphadenopathies were found. There were palpable intraluminal polyps with an inverted serosal surface for some of them, which were identified as 10cm proximal and 20cm distal to the mass. The pus was sucked out, and the mass was resected with its mesenteric lymph nodes and segments containing polyps, a total of 40cm of jejunum. Subsequently, end-to-end hand-sewn anastomosis was performed, and the abdomen was closed. The histopathology report showed poorly differentiated adenocarcinoma, stage IIIC (PT3, PN2), and Peutz-Jeghers polyps, suggesting Peutz-Jeghers syndrome. Lympho-vascular invasion was also noted. The tumor has affected seven of the 12 lymph nodes that have been identified. After 6weeks of uneventful follow-up at the surgical referral clinic, the patient was referred to the oncology department for adjuvant chemotherapy.
22 studies on the registry are indexed under Peutz-Jeghers Syndrome; 8 are open to participants now.
This study's enrollment of 1 is below the median of 347 across 12 observational studies indexed under Peutz-Jeghers Syndrome.
Browse Peutz-Jeghers Syndrome studies →Haramaya Unversity is the lead sponsor of 9 studies on the registry; 1 is open to participants now.
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Exclusion Criteria:
Complete resection of adenocarcinomas located in the jejunum or ileum is associated with 5-year survival rates of 20% to 30%.
Even though small bowel malignancy is a rare entity, early detection is a challenging issue, especially when it happens below the ligaments of the trietz. Peutz-Jeghers syndrome was a potential risk factor in our case.
Time frame: 5months
Plan to share: Yes — all IPD that underlie results in a publication
Supporting information: Study protocol
Time frame: after publication
No publications or documents are linked to this record.
Ran from Jul 2023 to primary completion in Dec 2023, 5 months.
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This study is completed, as verified in Feb 2024. You cannot join it, but the record below documents what was studied.
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Haramaya Unversity