An interventional study of Walnuts and Simply White Diary-free chocolate bar in Cognitive Decline and Cognitive Impairment, sponsored by Ohio State University. Recruiting at 1 site in United States. Open to participants aged 40 Years to 75 Years. Per ClinicalTrials.gov, last updated 2026-04-21.
Sponsored by Ohio State University · Not applicable, Interventional, and Treatment
The proposed research is a randomized crossover trial designed to assess changes in postprandial cognitive function and the gut-brain axis in adults with subjective cognitive complaints who consume 1 study snack per day for 1 week.
Study objective including
3,843 studies on the registry are indexed under Cognitive Dysfunction; 1,100 are open to participants now.
This study's planned enrollment of 88 is above the median of 65 across 2,808 interventional studies indexed under Cognitive Dysfunction.
Browse Cognitive Dysfunction studies →Ohio State University is the lead sponsor of 640 studies on the registry; 144 are open to participants now.
Of its 60 completed or terminated interventional studies of FDA-regulated products, 45 (75%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
consumption of walnuts every day
Other: Walnuts
consumption of a white chocolate-style bar every day
Other: Simply White Diary-free chocolate bar
56g of walnuts consumed each day for 7 days
68g of the white chocolate style-bar each day for 7 days
Cognitive function measured using the National Institutes of Health Toolbox for the Assessment of Neurological and Behavioral Function Cognitive Battery (NIHTB-CB)
To determine the impact of consuming the study dietary fats as part of a high fat meal on postprandial cognitive function
Time frame: Week 0 and Week 5
Change in Cognitive function measured using the National Institutes of Health Toolbox for the Assessment of Neurological and Behavioral Function Cognitive Battery (NIHTB-CB)
To assess changes in cognitive function after consuming 1 serving of the dietary fats every day for 1 week
Time frame: Week 0, Week 1, Week 5 and Week 6
Changes in fecal Microbiota diversity
To assess changes in microbiota diversity of fecal samples after consuming 1 serving of the dietary fats every day for 1 week
Time frame: Week 0, Week 1, Week 5 and Week 6
Changes in postprandial energy metabolism
To evaluate the effect of dietary fats on postprandial indirect calorimetry (kilocalories)
Time frame: Week 0 and Week 5
Changes in postprandial respiratory quotient
To evaluate the effect of dietary fats on postprandial respiratory quotient to identify what fuels (carbohydrate protein or fat) are utilized
Time frame: Week 0 and Week 5
Changes in postprandial lipids
To evaluate the effect of dietary fats on postprandial lipid panel including total cholesterol, HDL-Cholesterol, LDL-Cholesterol, Triglycerides (mg/dL)
Time frame: Week 0 and Week 5
Changes in postprandial Tumor necrosis factor levels
To evaluate the effect of dietary fats on postprandial blood Tumor necrosis factor alpha (TNF), a marker of inflammation
Time frame: Week 0 and Week 5
Changes in postprandial IL-6
To evaluate the effect of dietary fats on postprandial blood IL-6 a marker of inflammation
Time frame: Week 0 and Week 5
Changes in postprandial C-Reactive Protein
To evaluate the effect of dietary fats on postprandial blood C-reactive protein, a marker of inflammation
Time frame: Week 0 and Week 5
Changes in postprandial Soluble intercellular adhesion molecule-1
To evaluate the effect of dietary fats on postprandial blood Soluble intercellular adhesion molecule-1, a marker of inflammation
Time frame: Week 0 and Week 5
Changes in cardiolipin species
To determine the impact of dietary fat on peripheral blood mononuclear cell cardiolipin species measured using electrospray ionization-mass spectrometry coupled to high-performance liquid chromatography
Time frame: Week 0, Week 1, Week 5 and Week 6
Changes in postprandial glucose levels
To determine the impact of dietary fat on postprandial blood glucose levels
Time frame: Week 0 and Week 5
Changes in postprandial insulin levels
To determine the impact of dietary fat on postprandial blood insulin levels
Time frame: Week 0 and Week 5
Changes in postprandial cortisol levels
To determine the impact of dietary fat on postprandial salivary cortisol levels
Time frame: Week 0 and Week 5
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Ohio State University