ClinicalTrials.gg
Enrolling by invitationNCT06211387Updated Oct 3, 2024

ADDITIVE BENEFITS of KALTENBORN SUSTAINED STRETCH JOINT MOBILIZATION with RESISTANCE EXERCISE TRAINING in KNEE OSTEOARTHRITIS

An interventional study of Resistance Exercise Training and Joint Mobilization in Knee Osteoarthritis, sponsored by Foundation University Islamabad. Enrolling by invitation at 1 site in Pakistan. Open to participants aged 40 Years to 65 Years. Per ClinicalTrials.gov, last updated 2024-10-03.

Sponsored by Foundation University Islamabad · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Primary completion was expected by Apr 2025, 1 year 6 months ago, but the record still lists the study as enrolling by invitation.
Phase
Not applicable
Study type
Interventional
Enrollment
42
Allocation
Randomized
Ages
40 Years to 65 Years
Sex
All
01

Study summary

to determine the supplementary effects of Kaltenborn sustained stretch mobilization when combined with resistance training in the management of knee osteoarthritis.

02

Conditions studied

  • Knee Osteoarthritis
03

In context

Osteoarthritis, Knee

3,391 studies on the registry are indexed under Osteoarthritis, Knee; 628 are open to participants now.

This study's planned enrollment of 42 is below the median of 69 across 2,808 interventional studies indexed under Osteoarthritis, Knee.

Browse Osteoarthritis, Knee studies →

Lead sponsor

Foundation University Islamabad is the lead sponsor of 253 studies on the registry; 140 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
40 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

Grade I-III knee OA Both male and female nee osteoarthritis for at least 3 months knee pain no more than 8/10

Exclusion criteria

Exclusion Criteria:

Malignancy Any additional Inflammatory disorders Infection Knee trauma lower limb fracture Lumbar radiculopathy or myelopathy knee surgery Intra-articular steroid therapy in the last 2 months Total knee replacement (TKR). Total hip replacement (THR). Any neurological disorder Any cardio-pulmonary complications Rheumatoid arthritis Septic arthritis Recent history of trauma Osteoporosis or osteomyelitis Grade IV osteoarthritis

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05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
42 participants (estimated)

Study arms

  • Experimental
    Resistance exercise + joint mobilization

    Procedure: Resistance Exercise Training · Procedure: Joint Mobilization

  • Active comparator
    Resistance Exercise

    Procedure: Resistance Exercise Training

Interventions

  • ProcedureResistance Exercise Training

    Resistance Exercise Training for knee

  • ProcedureJoint Mobilization

    Tibiofemoral and Patellofemoral Joint Mobilization

06

What researchers measure

Primary outcomes

  1. Knee Pain

    Knee Pain will be quantified using Numeric Pain Rating Scale (NPRS). NPRS is a 11 point scale form 0-10. Lower Score on NPRS signifies less pain, whereas higher score on NPRS signifies more pain.

    Time frame: 4 weeks

  2. Physical Function

    To determine the physical function related to knee osteoarthritis Western Ontario and McMaster Universities Arthritis Index (WOMAC) will be used with a total of 24 items and a higher score on WOMAC signifies poor outcome.

    Time frame: 4 weeks

  3. Isometric Muscle Strength

    Modified Sphygmomanometer will be used to measure isometric muscle strength of the muscles of the knee joint. A higher score signifies greater strength.

    Time frame: 4 weeks

  4. Functional Mobility strength

    5 repetition sit to stand test will be used to determine functional mobility strength. Less time to complete the task signifies better outcome.

    Time frame: 4 weeks

  5. Cadence

    Observational gait analysis will be used to determine cadence. A higher score signifies better outcome.

    Time frame: 4 weeks

  6. Gait velocity

    Observational gait analysis will be used to determine cadence. A higher score signifies better outcome.

    Time frame: 4 weeks

  7. Stride length

    Observational gait analysis will be used to determine cadence. A higher score signifies better outcome.

    Time frame: 4 weeks

  8. Knee range of motion (ROM)

    Gonimeter will be used to measure knee range of motion.. A higher score signifies better outcome.

    Time frame: 4 weeks

07

Study locations

1 site
  • Foundation University Islamabad
    Islamabad, Federal 66000, Pakistan
08

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Started Oct 2024 (actual). Primary completion is estimated for Apr 2025, 6 months after the start.

Of 1,143 non-industry interventional studies with no phase under Osteoarthritis, Knee, half reached primary completion within 18 months of starting (the median), counting those still running; a quarter within 8 and three quarters within 36. This study's planned 6 months is below that.

Counting every sponsor, half of 1,285 studies reached it within 18 months; a quarter within 8 and three quarters within 36.

How these figures are worked out, and which studies are left out of them.

Registered
Jan 8, 2024
First posted
Jan 18, 2024
StartActual
Oct 1, 2024
Primary completionEst.
Apr 2, 2025
CompletionEst.
Apr 2, 2025
Last update
Oct 3, 2024
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Oct 3, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT06211387
Responsible party
Sponsor
First posted
Jan 18, 2024
Start date
Oct 1, 2024
Primary completion
Apr 2, 2025 (estimated)
Completion
Apr 2, 2025 (estimated)
Last update
Oct 3, 2024

Study contacts

Anas Hameed
principal investigator · Foundation University Islamabad
Muhammad Osama
study chair · Foundation University Islamabad

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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No contact was published for this record. The registry link below has the sponsor’s details.

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