An interventional study of Behavioral Intervention and Biospecimen Collection in Abuse Tobacco and Exposure, sponsored by Ohio State University Comprehensive Cancer Center. Active, not recruiting at 1 site in United States. Open to participants aged 21 Years to 29 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-06-15.
Sponsored by Ohio State University Comprehensive Cancer Center · Not applicable, Interventional, and Health services research
This study evaluates how synthetic cooling additives like WS-3 and WS-23 impact e-cigarette perceptions, use behavior, and toxicant exposure.
PRIMARY OBJECTIVES:
I. Assess the abuse liability of e-liquids with and without the presence of synthetic cooling agents.
II. Determine the impact of synthetic cooling agents and flavor on EC puffing behavior (topography).
III. Determine the exposure ranges (harmful and potentially harmful constituents [HPHCs], other toxicants) from vaping e-liquids with and without the presence of synthetic cooling agents.
OUTLINE:
Participants attend 4 sessions where they receive 1 of 4 randomly assigned flavored e-cigarettes. Participants use the e cigarettes for vaping followed by ad libitum vaping. Participants also complete surveys and undergo biosample collection throughout the study.
968 studies on the registry are indexed under Tobacco Use Disorder; 126 are open to participants now.
This study's enrollment of 158 is above the median of 89 across 851 interventional studies indexed under Tobacco Use Disorder.
Browse Tobacco Use Disorder studies →Ohio State University Comprehensive Cancer Center is the lead sponsor of 369 studies on the registry; 81 are open to participants now.
Of its 38 completed or terminated interventional studies of FDA-regulated products, 19 (50%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Synthetic cooling agents will be added to fruit flavored e-liquid for this condition.
Behavioral: Behavioral Intervention · Other: Biospecimen Collection · Other: Survey Administration
Fruit flavored e-liquid will be used for this condition.
Behavioral: Behavioral Intervention · Other: Biospecimen Collection · Other: Survey Administration
Synthetic cooling agents will be added to tobacco flavored e-liquid for this condition.
Behavioral: Behavioral Intervention · Other: Biospecimen Collection · Other: Survey Administration
Tobacco flavored e-liquid will be used for this condition.
Behavioral: Behavioral Intervention · Other: Biospecimen Collection · Other: Survey Administration
Receive and use flavored e-cigarettes (EC) as directed
Undergo biosample sample collection
Also known as: Biological Sample Collection, Specimen Collection
Complete surveys
Satisfaction and psychological reward
Satisfaction and psychological reward of e-cigarette (EC) vaping will be measured by the Modified Cigarette Evaluation Questionnaire (mCEQ). The mCEQ asks questions relating to satisfaction of using e-cigarettes on a scale from 0 (Not at all) - 6 (Extremely).
Time frame: Minute 5 of vaping session, Minute 35 of vaping session
Sensory perceptions of EC vaping experience
Sensory perceptions of EC vaping will be measured by the Sensory E-cigarette Expectancies Scale (SEES) questionnaire. The SEES asks questions about sensory experiences associated with vaping on a scale from 0 (Never) - 4 (Almost Always).
Time frame: Pre-vaping session
E-cigarette puff topography
Will be measured with a topography device that records frequency, duration, and flow rate of EC puffs. These measures are combined to inform overall EC puff behavior.
Time frame: 35 Minute Vaping session
Levels of HPHC and other toxicant exposure from vaping e-liquids
Topography data collected for all participants for each of the conditions vaped will be averaged to produce four human-derived puffing regimens. Machine vaping will be conducted for each of the four e-liquids using the associated human-derived puffing regimens to determine the range of HPHCs and other toxicants in mainstream EC vapor.
Time frame: After completion of sessions, estimated 4 years
Appeal and Sensory
Participants will rate appeal (e.g., liking, disliking) and sensory attributes (e.g., harshness, coolness) outcomes on Visual Analogue Scales (range, 0-100).
Time frame: Minute 5 of vaping session, Minute 35 of vaping session
Economic demand breakpoint
The price point at which a participant is no longer willing to pay for a puff of the study e-liquid will be determined by an EC purchase task questionnaire.
Time frame: Minute 35 of vaping session
Plan to share: No
This study is active, not recruiting, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.
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Ohio State University Comprehensive Cancer Center