An observational study in Infective Endocarditis, sponsored by Assiut University. Status unknown at 1 site in Egypt. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-06-25.
Sponsored by Assiut University · Observational
We aim to describe the incidence of IVDA among patients presented with IE, describe their clinical, psychiatric and microbiological characteristics in comparison to non - IVDA, as well as the rate and types of complications and outcome, and responsiveness to medical treatment or surgical intervention.
Infective endocarditis (IE) is the infection of the endocardial surface of the heart mainly affecting the valves of the heart. It is still associated with very high morbidity and mortality all over the world despite various advances in diagnostic and treatment methods.
A few studies have shown that infective endocarditis represents less than 0.5% of adult cardiovascular admissions.While the overall incidence of IE has remained stable over the last several years, IE has increased in young people in parallel with injection drug use (IDU) behaviours and the growing opioid crisis.
According to recent guidelines , Intravenous (IV) drug use is considered a minor Duke criteria for the diagnosis of infective endocarditis.
Compared to the general population, intravenous drug abuse (IVDA) is associated with an up to 100-fold increased risk of IE through several mechanisms, including endothelial injury from injected particulate matter, direct injection of contaminated material, and drug-associated vasospasm leading to intimal damage and thrombus formation.
Also, IVDA is associated with HIV outbreaks, which is a well-known risk factor for IE. HIV-associated IE is associated with high rates of morbidity and mortality than non-HIV-associated IE.Because of its pathophysiology, IVDA-associated IE is more commonly right-sided. Beyond these known characteristics, however, literature on this topic is substantially limited, including the clinical and microbiological characteristics of these patients, rate and types of complications and outcomes.
174 studies on the registry are indexed under Endocarditis; 52 are open to participants now.
This study's planned enrollment of 46 is below the median of 256 across 84 observational studies indexed under Endocarditis.
Browse Endocarditis studies →Assiut University is the lead sponsor of 5,050 studies on the registry; 2,174 are open to participants now.
Of its 14 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
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Patients admitted to Assiut University Heart Hospital with definite or possible Infective endocarditis
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Infective endocarditis in intravenous drug abusers
Diagnostic Test: Echocardiography, Urine analysis , blood culture
Infective endocarditis in non - intravenous drug abusers
Diagnostic Test: Echocardiography, Urine analysis , blood culture
All patients will be investigated by ECG, Urine analysis, blood culture , Echocardiography
The incidence of IVDA among IE patients
Report the incidence of IVDA among IE patients, describe their clinical and microbiological characteristics comparison to the IE in non - IVDA.
Time frame: Baseline
The complications of IVDA among IE patients
Report the rates and types of complications
Time frame: Baseline
The psychiatric characteristics of the addict group
This will be done by psychiatric questionnaires: -Addiction Severity Index questionnaire to measure severity of the addiction on the patient
Time frame: Baseline
The Withdrawal symptoms of the study group
This will be done by psychiatric questionnaires: -Withdrawal symptoms questionnaire that occur to the patient after stop of the addiction
Time frame: Baseline
The psychiatric characteristics of the study group
This will be done by psychiatric questionnaires: -Symptom Check List 90 to measure other comorbidities
Time frame: Baseline
The personality characteristics of the study group
This will be done by psychiatric questionnaires: -Eysenck Personality questionnaire to measure personality.
Time frame: Baseline
This study is status unknown, as verified in Jun 2024. You cannot join it, but the record below documents what was studied.
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