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CompletedNCT06184620Updated Dec 28, 2023

Correlation Between Angle Closure Glaucoma Data and Lens Zonule Status

An observational study in Primary Angle Closure Glaucoma, sponsored by Guangfu Dang. Completed at 1 site in China. Open to participants aged 47 Years to 91 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-12-28.

Sponsored by Guangfu Dang · Observational

Study type
Observational
Model
Other
Time perspective
Retrospective
Enrollment
263
Ages
47 Years to 91 Years
Sex
All
01

Study summary

The goal of this observational study is to discuss the correlation between primary angle-closure glaucoma and the state of the suspended ligament of the lens and the pathogenesis of PACG by measuring the biological data of primary angle-closure glaucoma and observing its anatomical changes.

Read the detailed description

Patients clinically diagnosed with Primary angle-closure glaucoma (PACG) and normal control patients from December 2020 to January 2022 were enrolled in this study.

02

Conditions studied

  • Primary Angle Closure Glaucoma

Keywords

  • primary angle closure glaucoma
  • UBM
  • lens zonule
03

Who can participate

Ages eligible
47 Years to 91 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

From December 2020 to January 2022, patients with primary angle-closure glaucoma and normal control patients were diagnosed for the first time and intended to undergo cataract surgery in the ophthalmology department of the First Affiliated Hospital of Shandong First Medical University (Shandong Qiandfo Hospital).

Inclusion criteria

  • The depth of the anterior chamber is normal, and the whole corner of the chamber is open;
  • The cup-to-plate ratio is less than 0.5;
  • No family history of glaucoma.

Exclusion criteria

Exclusion Criteria:

  • Previous history of trauma or internal eye surgery in both eyes or one eye;
  • Used "pilocarpine", "atropine" and other drugs to change the size of the pupil and the shape of the chamber Angle within 1 week;
  • Combined with other eye diseases affecting the Angle and suspension ligament, such as uveitis, ciliary cyst, high myopia, retinal diseases, etc.;
  • Can not cooperate with UBM and Angle scopy;
  • Refuse to participate in this researcher.
04

Study design

Observational model
Other
Time perspective
Retrospective
Enrollment
263 participants (actual)
Patient registry
No

Groups and cohorts

  • PACG group

    All patients in the experimental group met the diagnostic criteria of primary angle-closure glaucoma in the Chinese Glaucoma Guidelines(2020).

  • control group

    The depth of the anterior chamber is normal, and the whole corner of the chamber is open; The cup-to-plate ratio is less than 0.5; No family history of glaucoma

05

What researchers measure

Primary outcomes

  1. Axial Length (AL), Lens Thickness (LT),Lens Vault (LV), Pupil Diameter (PD),

    Axial Length (AL), Lens Thickness (LT),Lens Vault (LV), Pupil Diameter (PD),

    Time frame: before operation

  2. Anterior Chamber Depth (ACD) in seat and rectum position, White To White (WTW), pupil vault (LV), pupil diameter (PD), The Lens Zonular Length (LZL) and Angle Opening Distance at 500μm (AOD500) in the upper, lower, nasal and temporal directions

    Anterior Chamber Depth (ACD) in seat and rectum position, White To White (WTW), pupil vault (LV), pupil diameter (PD), The Lens Zonular Length (LZL) and Angle Opening Distance at 500μm (AOD500) in the upper, lower, nasal and temporal directions

    Time frame: before operation

06

Study locations

1 site
  • guangfu Dang
    Jinan, Shandong 250000, China
07

Registry details

Key details

Study ID
NCT06184620
Lead sponsor
Guangfu Dang
Responsible party
Guangfu Dang (professor, Qianfoshan Hospital) — Sponsor-investigator
First posted
Dec 28, 2023
Start date
Dec 1, 2020
Primary completion
Mar 30, 2023
Completion
Mar 30, 2023
Last update
Dec 28, 2023

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Dec 2023. You cannot join it, but the record below documents what was studied.

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