An interventional study of Acceptance and commitment therapy in Endometriosis and Chronic Pain, sponsored by Skane University Hospital. Recruiting at 1 site in Sweden. Open to female participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-02-19.
Sponsored by Skane University Hospital · Not applicable, Interventional, and Treatment
The primary aim of this study is to investigate the effect of Internet-delivered Acceptance and commitment therapy for endometriosis and chronic pain. A pilot study (no randomization; N=10) will be conducted to test the intervention and assessment procedures. The participants will go through an active internet-based ACT treatment focused on education about endometriosis and chronic pain, value-based exposure for avoided situations, and behavior change through exercises targeting the processes mindfulness, cognitive defusion and acceptance. The treatment is delivered on a safe internet platform. Participants have planned telephone contact with their assigned psychologist 2 times during the program and can also contact their psychologist via a message system in the platform and expect answer within 48 hours.
Objective The primary aim of this study is to investigate the effect of Internet-delivered Acceptance and commitment therapy (iACT)for endometriosis.
Sample size 10 participants.
Trial design All participants are offered treatment. Participants are recruited from the Pain Rehabilitation Unit and the team for endometriosis at Skåne University Hospital. The unit is a government supported, regional specialist center focused on assessment and treatment of chronic pain and related disability.
Assessments Baseline and posttreatment (2 weeks after treatment) assessments will be conducted. Self-report measures will also be collected at baseline, post-treatment as well as during a 3-month follow up.
Assessment includes:Pre-and post assessment Assessors collected demographic information and self-report measures. During the pre-assessment the Mini International Neuropsychiatric Interview 5.0 (MINI) was administered to detect the presence of other comorbid disorders and assess inclusion criteria and rule out exclusion criteria.
During treatment During treatment the treatment credibility scale was administered to assess the patients' perceptions of how credible the treatment was following the introduction of the treatment rationale and the main treatment components (included in the internet program).
Safety parameters: As a mean to monitor safety and progress participants complete self-report measures (MPI, NRS, PIPS, PCS) and a question about suicidal ideation twice during the program and the therapist can follow these scores. In addition, participants can report any adverse events during treatment, at posttreatment and follow-up assessment.
Post-treatment exit interview At the post-assessment, the assigned assessor asked participants about their satisfaction with and experience of the program, what they found helpful or unhelpful and suggestions for future improvements.
Measures were taken at baseline, 2-weeks, 3 months follow-up. Self-report measures were mailed to participants
Main statistical analysis Between-group estimates on outcome will be conducted using repeated measurements. The analyses will be conducted using intention to treat principles and post hoc comparisons.
901 studies on the registry are indexed under Endometriosis; 259 are open to participants now.
This study's planned enrollment of 10 is below the median of 64 across 525 interventional studies indexed under Endometriosis.
Browse Endometriosis studies →Skane University Hospital is the lead sponsor of 71 studies on the registry; 17 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Acceptance and commitment therapy
Behavioral: Acceptance and commitment therapy
The participants will go through an active internet-based ACT treatment focused on education about endometriosis and chronic pain, value-based exposure for avoided situations, and behavior change through exercises targeting the processes mindfulness, cognitive defusion and acceptance. The treatment is delivered on a safe internet platform. Participants have planned telephone contact with their assigned psychologist 2 times during the program and can also contact their psychologist via a message system in the platform and expect answer within 48 hours.
Pain interference as measured by the Multidimensional Pain Inventory (MPI)
(changes between assessments) Min= 0; Max= 6. Higher scores indicate worse interference.
Time frame: Baseline, mid-treatment (3 weeks), mid-treatment (5 weeks), two-week-post treatment, 3 month-follow- up
Psychological inflexibility as measured by the Psychological Inflexibility in Pain Scale (PIPS)
(changes between assessments) (changes between assessments) Min=0; Max= 52. Higher scores indicate worse inflexibility
Time frame: Baseline, mid-treatment (3 weeks), mid-treatment (5 weeks), two-week-post treatment, 3 month-follow- up
Anxiety and depression as measured by the Hospital Anxiety and Depression Scale (HADS)
(changes between assessments) Min= 0; Max= 21. Higher scores indicate worse depression/anxiety.
Time frame: Baseline, two-week-post treatment, 3 month-follow- up
Pain intensity as measured by the Numerical Rating Scale (NRPS)
(changes between assessments) Min= 0; Max= 10. Higher scores indicate worse pain intensity.
Time frame: Baseline, mid-treatment (3 weeks), mid-treatment (5 weeks), two-week-post treatment, 3 month-follow- up
Pain catastrophizing as measured by the Pain Catastrophizing Questionnaire (PCS)
(changes between assessments) Min= 0; Max= 52. Higher scores indicate worse pain catastrophizing.
Time frame: Baseline, mid-treatment (3 weeks), mid-treatment (5 weeks), two-week-post treatment, 3 month-follow- up
Perceived health as measured by the RAND-36 Measure of Health-Related Quality of Life (RAND-36)
(changes between assessments)Min= 0; Max= 100. Lower scores indicate worse perceived health.
Time frame: Baseline, two-week-post treatment, 3 month-follow- up
Kinesiophobia as measured by the Tampa Scale of Kinesiophobia (Tampa)
(changes between assessments) Min= 17; Max= 68. Higher scores indicate worse kinesiophobia
Time frame: Baseline, two-week-post treatment, 3 month-follow- up
Health care utilization as measured by the health-care database of Region Skåne
(changes between assessments)
Time frame: Baseline, 3 month-follow- up
Health-related quality of life as measured by the Endometriosis Health Profile (EHP-30)
(changes between assessments) Min=0; Max= 100. Lower scores indicate better health-related quality of life
Time frame: Baseline, two-week-post treatment, 3 month-follow- up
Plan to share: No
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Skane University Hospital