An interventional study of Smell Test in Olfactory Disorder, Smell Disorder and Traumatic Brain Injury, sponsored by University of Kansas Medical Center. Enrolling by invitation at 1 site in United States. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2026-06-16.
Sponsored by University of Kansas Medical Center · Not applicable, Interventional, and Treatment
To date, there is no validated pharmacotherapy for olfactory disorders. Interestingly, olfactory training - the intentional exposure to odorants for the purposes of retraining the sense of smell - has shown success with as many as 28% of subjects over the course of 12 weeks.
Study Objectives: The overall, primary goals of these studies are as follows:
70 studies on the registry are indexed under Olfaction Disorders; 18 are open to participants now.
This study's planned enrollment of 250 is above the median of 60 across 49 interventional studies indexed under Olfaction Disorders.
Browse Olfaction Disorders studies →University of Kansas Medical Center is the lead sponsor of 492 studies on the registry; 110 are open to participants now.
Of its 38 completed or terminated interventional studies of FDA-regulated products, 24 (63%) have results posted.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Participants will be asked to inhale 4 different scents 2 times a day.
Other: Smell Test
Participants will be asked to inhale 14 different scents 2 times a day.
Other: Smell Test
Oils are used for each of the different scents. Each scent is administered via an aromatherapy inhaling stick.
Olfactory Threshold
Changes in olfactory threshold when comparing pre- and post-olfactory training for performance in terms of percent correct per specific scent and overall combination of percent correct for all tested scents
Time frame: Change from baseline to month 6
Olfactory Identification
Changes in ability to detect and identify scents when comparing pre- and post-olfactory training for percent detected per individual scents and as a composite score reflecting performance on all scents
Time frame: Change from baseline to month 6
Tolerance with Olfactory Training Protocol
Self-reported tolerance with following olfactory training protocol
Time frame: At follow-up visits
Neurocognition
Assessment of neurocognition and impact on olfactory quality of life using the Mini-Mental Status Exam (MMSE) and Montreal Cognitive Assessment (MoCA)
Time frame: Change from baseline to month 6
Plan to share: No
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University of Kansas Medical Center →