An interventional study of measure Osteocalcin level in Periodontal Diseases, sponsored by Faculty of Dental Medicine for Girls. Completed at 1 site in Egypt. Open to female participants aged 25 Years to 35 Years. Per ClinicalTrials.gov, last updated 2023-11-28.
Sponsored by Faculty of Dental Medicine for Girls · Not applicable, Interventional, and Diagnostic
Osteocalcin levels can be measured Gingival crevicular fluid (GCF). Changes in osteocalcin levels can provide important information about the status of bone metabolism and bone remodeling. The levels of this markers in GCF can provide information about the status of bone remodeling in the surrounding bone tissue in periodontal affected teeth.
Osteocalcin levels can be measured using a blood test or by analyzing the levels of osteocalcin in urine or saliva. Changes in osteocalcin levels can provide important information about the status of bone metabolism and bone remodeling. Osteocalcin has been found to be present in Gingival crevicular fluid (GCF), along with other bone metabolism markers such as alkaline phosphatase and tartrate-resistant acid phosphatase. The levels of these markers in GCF can provide information about the status of bone remodeling in the surrounding bone tissue. Orthodontic tooth movement is influenced by the remodelling ability of surrounding bone and soft tissue, such as PDL and gingiva. Bone remodelling occurs in coordination, requiring coupling of bone formation after resorption. Orthodontic force induces an aseptic inflammatory response, involving cytokines and chemokines. . Increased levels of osteocalcin in body fluids indicate abnormal bone turnover activity.
830 studies on the registry are indexed under Periodontal Diseases; 188 are open to participants now.
This study's enrollment of 15 is below the median of 45 across 530 interventional studies indexed under Periodontal Diseases.
Browse Periodontal Diseases studies →Faculty of Dental Medicine for Girls is the lead sponsor of 52 studies on the registry; 4 are open to participants now.
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Exclusion Criteria:
periodontal compromised adults female patients with sever dental crowding and seeking for orthodontic treatment
Diagnostic Test: measure Osteocalcin level
in gingival crevicular fluid before and during orthodontic tooth movement
Osteocalcin levels in gingival crevicular fluid before and during orthodontic tooth movement
ELISA test to measure osteocalcin in GCF
Time frame: at baseline, then after 3 months and after 6 month
Plan to share: No
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This study is completed, as verified in Nov 2023. You cannot join it, but the record below documents what was studied.
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Faculty of Dental Medicine for Girls