CClinicalTrials.gg
CompletedNCT06070571Updated Oct 6, 2023

Clinical Evaluation and Assesment of Ginigivitis Patients Treated by Yarrow Natural Extract in Compare to a Contro Group

A Phase 1 interventional study of Yarrow and moringa mixture in Gingivitis, sponsored by Deraya University. Completed at 1 site in Egypt. Open to participants aged 25 Years to 55 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-10-06.

Sponsored by Deraya University · Phase 1, Interventional, and Treatment

From the registry’s dates

  • Registered 1 year 4 months after the study started (first participant enrolled May 2022, registered Sep 2023).
Phase
Phase 1
Study type
Interventional
Enrollment
40
Allocation
Randomized
Ages
25 Years to 55 Years
Sex
All
01

Study summary

A double-blind, prospective, randomized, intra-individual comparative, single-center clinical study was conducted. Participants were placed in parallel groups, and the study was performed in the Department of Operative Dentistry and Periodontology, Dental School and Hospital, Minia university to compare the antibacterial activity of yarrow Moringa herbal combinations nanoparticles in compared to Chlorhexidine as a potential treatment for gingivitis.

02

Conditions studied

  • Gingivitis

Browse trials for

03

In context

Gingivitis

590 studies on the registry are indexed under Gingivitis; 104 are open to participants now.

This study's enrollment of 40 is below the median of 64 across 478 interventional studies indexed under Gingivitis.

Browse Gingivitis studies →

Lead sponsor

Deraya University is the lead sponsor of 48 studies on the registry; 4 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
25 Years to 55 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • a minimum of four natural uncrowned teeth in one quadrant present
  • good general health
  • can follow instructions

Exclusion criteria

Exclusion Criteria:

  • were pregnant or breastfeeding
  • evidence of antibiotic use during the 4 weeks prior to the study
  • were allergic to personal care/consumer products or their ingredients
05

Study design

Phase
Phase 1
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Participant)
Enrollment
40 participants (actual)

Study arms

  • Experimental
    Intervention group

    Bucco-adhesive films with Yarrow and Moringa extract nanoparticles

    Drug: Yarrow and moringa mixture

  • Active comparator
    control group

    Cholorohexiden oral gargles

    Drug: Yarrow and moringa mixture

Interventions

  • DrugYarrow and moringa mixture

    yarrow and moringa mixture nano particles loaded on buccal film

06

What researchers measure

Primary outcomes

  1. antibacterial and anti inflammatory activities

    scoring of erthymia and pain (no pain=0) and the other end (worst pain=10).

    Time frame: two weeks

07

Study locations

1 site
  • Soad A. Mohamad
    Minya, المنيا 05673, Egypt
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 6, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT06070571
Lead sponsor
Deraya University
Responsible party
Sponsor
First posted
Oct 6, 2023
Start date
May 20, 2022
Primary completion
Dec 20, 2022
Completion
May 20, 2023
Last update
Oct 6, 2023

Study contacts

soad ali, PhD
study director · faculty of pharmacy, Deraya university

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Sep 2023. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion