CClinicalTrials.gg
CompletedNCT06065241Updated Jan 15, 2026

Quantifiably Determine if the Botanical Formulation, LLP-01, Has a Significant Clinical Effect on Proteomic Inflammatory and Cardiovascular Biomarkers in Healthy, Older Individuals.

An interventional study of LLP-01 and Placebo in Aging and Inflammation, sponsored by LL Prosper Inc.. Completed at 1 site in United States. Open to participants aged 50 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-01-15.

Sponsored by LL Prosper Inc. · Not applicable, Interventional, and Other

Phase
Not applicable
Study type
Interventional
Enrollment
32
Allocation
Randomized
Ages
50 Years to 75 Years
Sex
All
01

Study summary

This is a prospective, interventional, double-blinded placebo-controlled study of up to 40 participants to evaluate the effect of a botanical formulation on inflammatory and cardiovascular biomarkers .

Read the detailed description

The objective of this study is to understand the impact of a multi-botanical formulation on measurements of protein markers, with a focus on inflammation over a 60-day period. The primary objective of this study is to assess the effect of the formulation, LLP-01, on inflammatory and cardiovascular proteomic biomarkers. Adverse events will be self-monitored by participants and will be reported. Changes in weight/calculated BMI and grip strength, as well as changes in well-being through a self-reported questionnaire will also be measured.

02

Conditions studied

  • Aging
  • Inflammation

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03

In context

Inflammation

3,439 studies on the registry are indexed under Inflammation; 629 are open to participants now.

This study's enrollment of 32 is below the median of 50 across 2,437 interventional studies indexed under Inflammation.

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Lead sponsor

This is the only study on the registry with LL Prosper Inc. as lead sponsor.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
50 Years to 75 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Age: 50-75 years of age
  • Any sex / gender
  • All ethnicities
  • Able to participate in a 2 month trial
  • Able to provide informed consent
  • Participant must be able to comply with treatment plan and laboratory tests
  • Can swallow 00 size capsules

Exclusion criteria

Exclusion Criteria:

  • Any clinically diagnosed medical disease or disorder that requires prescribed medication(s)
  • Currently on any anticoagulant medicines, such as warfarin
  • Planned surgical procedure during study period
  • Consumption of any supplements within the last 30 days that include the following botanicals/ingredients: green tea extract, Ashwagandha, Fisetin, Curcumin/Turmeric extract, Rosemary extract, Cordyceps, Ginseng
  • Allergy or other sensitivity to any of the botanicals in the investigated product
  • Currently or have been sick (bacterial or viral infection) in the last 14 days
  • Alcoholism or drug addiction
  • Participation in a clinical research trial within 30 days prior to enrollment in this trial
  • Cognitive impairment, illiteracy, inability or unwillingness to give voluntary informed consent
  • Unable or unwilling to provide required blood sample for testing and for use in a scientific publication (personal information undisclosed)
  • Participants with any condition that may preclude venipuncture/ venous blood draw
05

Study design

Phase
Not applicable
Primary purpose
Other
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Investigator)
Enrollment
32 participants (actual)

Study arms

  • Experimental
    Experimental Group

    Participants in this arm will receive a herbal capsule formulation, called LLP-01, consisting of 2 capsules taken once daily without food for 60 days. The capsules contain extracts from naturally occurring plant species, including Withania somnifera, Rosmarinus officinalis, Curcuma longa, Cotinus coggygria, Panax ginseng, Cordyceps militaris, Camellia sinensis, Cotinus coggygria, and Piper nigrum.

    Dietary Supplement: LLP-01

  • Placebo comparator
    Placebo Group

    Participants in this arm will receive Placebo capsules, which are visually identical to the capsules in the Experimental Group. These placebo capsules are filled with rice flour and a minor amount of Curcuma longa powder and should be taken in the same manner as the Experimental Group, with 2 capsules taken once daily without food for 60 days.

    Other: Placebo

Interventions

  • Dietary supplementLLP-01

    Participants in the experimental group will take 2 capsules daily containing 1,000mg of the formulation, LLP-01, for 60 days.

  • OtherPlacebo

    Participants in the placebo group will take 2 capsules daily containing rice flower and small amount of Curcuma Longa for 60 days.

06

What researchers measure

Primary outcomes

  1. Plasma Proteomic Changes

    Serum proteomic test to measure significant effects on any of the plasma proteins that will be analyzed. These proteins represent inflammatory, and cardiovascular responses, as well as metabolic functions.

    Time frame: Change from baseline to 60 days and compared to placebo

Secondary outcomes

  1. Grip Strength

    Digital grip strength device to measure absolute grip strength

    Time frame: Change from baseline to 60 days and compared to placebo

  2. Weight/BMI

    Height and weight to measuring absolute weight and to calculate BMI

    Time frame: Change from baseline to 60 days and compared to placebo

  3. Well-being

    Questionnaire covering different aspects of well-being

    Time frame: Change from baseline to 60 days and compared to placebo

07

Study locations

1 site
  • LL Prosper Inc.
    San Diego, California 92121, United States
08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 15, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06065241
Lead sponsor
LL Prosper Inc.
Responsible party
Sponsor
First posted
Oct 3, 2023
Start date
Sep 22, 2023
Primary completion
Mar 28, 2024
Completion
Mar 28, 2024
Last update
Jan 15, 2026

Study contacts

Adi Ramon, M.Sc
principal investigator · Chief Compliance Officer

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jan 2026. You cannot join it, but the record below documents what was studied.

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