CClinicalTrials.gg
CompletedNCT06063434Updated May 6, 2026Results posted

Testing the Effectiveness of Night Shift, a Theory-based Customized Video Game

An interventional study of Night Shift and Usual education in Trauma Injury and Physician's Role, sponsored by University of Pittsburgh. Completed at 1 site in United States. Open to participants aged 25 Years to 70 Years. Per ClinicalTrials.gov, last updated 2026-05-06.

Sponsored by University of Pittsburgh · Not applicable, Interventional, and Health services research

Phase
Not applicable
Study type
Interventional
Enrollment
800
Allocation
Randomized
Ages
25 Years to 70 Years
Sex
All
01

Study summary

The goal of this clinical trial is to test the effect of a video game on the implementation of clinical practice guidelines in trauma triage. The main question it attempts to answer is whether exposure to the game improves compliance with guidelines by emergency medicine physicians working at non-trauma centers in the US. Participants randomized to the intervention condition will be asked to play a customized, theory-based video game for 2 hours immediately after enrollment, and then return to the game for 20 minutes every three months for the next 9 months. Participants in the control condition will receive usual care.

Read the detailed description

Transfer of severely injured patients to trauma centers, either directly from the field or after evaluation at non-trauma centers, reduces preventable morbidity and mortality. Failure to transfer these patients appropriately (i.e., under-triage) remains common, and occurs in part because physicians at non-trauma centers make diagnostic errors when evaluating the severity of patients' injuries. The study team developed Night Shift, a theory-based adventure video game, to recalibrate physician heuristics (intuitive judgments) in trauma triage and established its efficacy in the laboratory. The investigators plan a Type 1 hybrid effectiveness-implementation trial to determine whether the game changes physician triage decisions in real-life, and hypothesize that it will reduce the proportion of patients under-triaged.

02

Conditions studied

  • Trauma Injury
  • Physician's Role

Browse trials for

Keywords

  • Heuristics
  • Serious game
  • Guidelines
03

In context

Accidental Injuries

51 studies on the registry are indexed under Accidental Injuries; 28 are open to participants now.

This study's enrollment of 800 is above the median of 115 across 30 interventional studies indexed under Accidental Injuries.

Browse Accidental Injuries studies →

Lead sponsor

University of Pittsburgh is the lead sponsor of 1,385 studies on the registry; 167 are open to participants now.

Of its 8 completed or terminated interventional studies of FDA-regulated products, 4 (50%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
25 Years to 70 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

- Board certified physicians who work exclusively in the emergency departments (EDs) of non-trauma centers in the US AND triage adult trauma patients

Exclusion criteria

Exclusion Criteria:

  • non-physician healthcare professionals who work in EDs
  • physicians who work at trauma and non-trauma centers
  • physicians who work outside the continental US
05

Study design

Phase
Not applicable
Primary purpose
Health services research
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
800 participants (actual)

Study arms

  • Experimental
    Night Shift

    Night Shift 2024 is a customized, theory-based adventure video game in which the player takes on the character of Andy Jordan, a young emergency medicine physician who moves home after the disappearance of his grandfather and takes a job at a local community hospital. The investigators will ask participants to play Night Shift for 2 hours upon enrollment (or within 2 weeks), and then come back to the game quarterly to play it again for 20 minute booster sessions. They will unlock additional game content each quarter to make the experience more enjoyable.

    Behavioral: Night Shift

  • Active comparator
    Usual education

    Participants will receive their usual continuing medical education, but nothing additional.

    Behavioral: Usual education

Interventions

  • BehavioralNight Shift

    The player must not only manage the patients who present to the emergency department of the hospital, gaining experience with the consequences of trauma triage, but also solve the mystery of the grandfather, gaining an emotional connection with the character and making the feedback that "Andy" receives more relevant. Embedded within Night Shift 2024 is a mini-game (Graveyard Shift) that contains a series of puzzles that reinforce the lessons of the overarching game: transfer severely injured patients expeditiously.

  • BehavioralUsual education

    Standard continuing medical education, including Advanced Trauma Life Support, and the American Board of Emergency Medicine educational modules (e.g., trauma resuscitation).

06

What researchers measure

Primary outcomes

  1. Under-triage

    Number of severely injured patients, treated by trial participants, who are admitted or discharged (i.e., not transferred) after initial evaluation at a non-trauma center as recommended by clinical practice guidelines.

    Time frame: 1 year

Secondary outcomes

  1. Mortality and Hospital Readmission

    Number of severely injured patients, treated by trial participants, who die or are readmitted to any hospital within 30 days of their initial evaluation at a non-trauma center

    Time frame: 1 year

  2. Functional Dependence

    Proportion of severely injured patients, treated by trial participants, with 90-day preadmission location at home with discharge to a skilled nursing or rehabilitation facility after initial treatment at a non-trauma center.

    Time frame: 1 year

  3. Over-triage

    Number of injured patients, treated by trial participants, transferred to a higher level of care after initial evaluation at a non-trauma center with minimal injuries. The Overall Number of Participants Analyzed reflects the number of enrolled physicians. The values in the data table report transferred patients treated by physicians enrolled in the trial.

    Time frame: 1 year

07

Results

Posted May 6, 2026
Limitations and caveats
1. We used Medicare Fee-for-Service 2. We used claims for outcome assessment 3. We assigned process of care to the individual physician, but recognize the complex contextual nature of trauma triage 4. We provided a material incentive to encourage task completion 5. Although missingness of data was low, we cannot exclude a small residual bias. 6. Our public protocol disclosed block sizes of 4 or 6, creating a theoretical risk of allocation prediction.

Participant flow

We recruited a national sample of physicians who managed injured patients in the Emergency Departments (EDs) of non-trauma centers by distributing information about the trial through social media, word-of-mouth, a healthcare analytics company, and the organizational e-mail distribution lists of several national physician staffing groups. We enrolled participants between November 27, 2023 - February 7, 2024.

Participant flow — Overall Study
MilestoneNight ShiftUsual Education
Started400400
Completed399398
Not completed12

Outcome measures

SecondaryMortality and Hospital Readmission

Number of severely injured patients, treated by trial participants, who die or are readmitted to any hospital within 30 days of their initial evaluation at a non-trauma center

Time frame:
1 year
Reported as:
Number · Severely Injured Patients
Mortality and Hospital Readmission
Severely Injured PatientsNight ShiftUsual Education
Composite outcome present — Composite outcome present516584
Composite outcome absent — Composite outcome present303335
Total number of severely injured patients — Composite outcome present819919
Statistical analysis
  • Night Shift vs Usual Education · Mixed Models Analysis · p = 0.87 (We were interested in any difference in our composite outcome between groups.) · Risk difference (rd): 1 · 95% CI 0 to 7We used a mixed effects logistic regression model with a fixed effect of assignment and clustered at the physician level.
SecondaryFunctional Dependence

Proportion of severely injured patients, treated by trial participants, with 90-day preadmission location at home with discharge to a skilled nursing or rehabilitation facility after initial treatment at a non-trauma center.

Time frame:
1 year

Results for this outcome have not been posted.

SecondaryOver-triage

Number of injured patients, treated by trial participants, transferred to a higher level of care after initial evaluation at a non-trauma center with minimal injuries. The Overall Number of Participants Analyzed reflects the number of enrolled physicians. The values in the data table report transferred patients treated by physicians enrolled in the trial.

Time frame:
1 year
Reported as:
Number · Transferred Patients
Over-triage
Transferred PatientsNight ShiftUsual Education
Transferred patients with minor injuries (over-triaged) — Patients with minor injuries (over-triaged)10381132
Transferred patients with severe injuries — Patients with minor injuries (over-triaged)417392
Total number of transferred patients — Patients with minor injuries (over-triaged)14551524
Statistical analysis
  • Night Shift vs Usual Education · Mixed Models Analysis · p = 0.14 (We set significance at p\<0.05) · Risk difference (rd): 3 · 95% CI 0 to 6Mixed effects logistic regression model with a fixed effect of assignment and clustered at the physician level.
PrimaryUnder-triage

Number of severely injured patients, treated by trial participants, who are admitted or discharged (i.e., not transferred) after initial evaluation at a non-trauma center as recommended by clinical practice guidelines.

Time frame:
1 year
Reported as:
Number · Severely injured patients
Under-triage
Severely injured patientsNight ShiftUsual Education
Total number of severely injured patients819919
Transferred severely injured patients417392
Not transferred severely injured patients402527
Statistical analysis
  • Night Shift vs Usual Education · Mixed Models Analysis · p = 0.02 (We set significance at p\<0.025) · Risk difference (rd): -7 · 97.5% CI -13 to -0.8

Adverse events

Collected over 1 year. Non-serious events are listed at a 0% frequency threshold.

Adverse event summary by group
GroupDeathsSeriousOther
Night Shift—0/399 (0%)0/399 (0%)
Usual Education—0/398 (0%)0/398 (0%)

Baseline characteristics

Age, Continuous
Age, Continuous(years)Night ShiftUsual EducationTotal
Median41 (37 to 49)42 (37 to 50)42 (37 to 49)
Sex: Female, Male
Sex: Female, Male(Participants)Night ShiftUsual EducationTotal
Female116110226
Male281282563
Race (NIH/OMB)
Race (NIH/OMB)(Participants)Night ShiftUsual EducationTotal
American Indian or Alaska Native123
Asian5462116
Native Hawaiian or Other Pacific Islander000
Black or African American131629
White300288588
More than one race000
Unknown or Not Reported323264
Ethnicity (NIH/OMB)
Ethnicity (NIH/OMB)(Participants)Night ShiftUsual EducationTotal
Hispanic or Latino161632
Not Hispanic or Latino360363723
Unknown or Not Reported242145
Region of Enrollment
Region of Enrollment(Participants)Night ShiftUsual EducationTotal
United States400400800
08

Study locations

1 site
  • University of Pittsburgh
    Pittsburgh, Pennsylvania 15213, United States
09

References and documents

Publications

  • Mohan D, Chang CH, Fischhoff B, Elmer J, Rak KJ, Barnes JL, Peitzman AB, Bendesky B, Carr C, Chapman AC, Forsythe RM, Guyette FX, Hynes AM, Oskvarek JJ, Weingart SD, Weinstock MB, White DB, Angus DC. Using Serious Games to Increase the Implementation of Trauma Triage Guidelines: A Randomized Clinical Trial. JAMA. 2026 May 19;335(19):1672-1683. doi: 10.1001/jama.2026.4079. PubMed 42008277 ↗
  • Mohan D, Fischhoff B, Talisa V, Elmer J, White DB, Angus DC, Peitzman A, Bendesky B, Chapman AC, Forsythe RM, Guyette FX, Hynes AM, Oskvarek JJ, Weingart SD, Weinstock M, Chang CH. An Educational Video Game in Trauma Triage at Nontrauma Centers: A Secondary Analysis of a Randomized Clinical Trial. JAMA Netw Open. 2025 Jun 2;8(6):e2513375. doi: 10.1001/jamanetworkopen.2025.13375. PubMed 40465299 ↗
  • Mohan D, Angus DC, Chang CH, Elmer J, Fischhoff B, Rak KJ, Barnes JL, Peitzman AB, White DB. Using a theory-based, customized video game as an educational tool to improve physicians' trauma triage decisions: study protocol for a randomized cluster trial. Trials. 2024 Feb 16;25(1):127. doi: 10.1186/s13063-024-07961-w. PubMed 38365758 ↗

Study documents

  • Study protocol · Sep 25, 2023
  • Statistical analysis plan · Mar 6, 2026
  • Informed consent form · Sep 19, 2023

Documents are hosted by the registry — open the source record to download them.

Individual participant data

Plan to share: Yes — The protocol, primary data, and meta-data (e.g., documentation, protocols used to clean and to manage the data), will be uploaded to the open access Inter-university Consortium for Political and Social Research (open ICPSR) repository at the conclusion of the trial. Of note, data obtained from Medicare will not be shared as part of the results of the trial, because we do not own those records.

Supporting information: Study protocol, Sap, Analytic code

10

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 6, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
11

Registry details

Key details

Study ID
NCT06063434
Lead sponsor
University of Pittsburgh
Collaborators
National Institute on Aging (NIA)
Responsible party
Deepika Mohan (Associate Professor, University of Pittsburgh) — Principal investigator
First posted
Oct 2, 2023
Start date
Nov 27, 2023
Primary completion
Mar 30, 2025
Completion
Mar 30, 2025
Results posted
May 6, 2026
Last update
May 6, 2026

Study contacts

Deepika Mohan, MD
principal investigator · University of Pittsburgh

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in May 2026. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion