A Phase 2 interventional study of Amnion collagen and Platelet-rich plasma in Facial Wrinkles - Rough Texture - Hyperpigmentation, sponsored by Egyptian Atomic Energy Authority. Completed at 1 site in Egypt. Open to female participants aged 36 Years to 57 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-10-04.
Sponsored by Egyptian Atomic Energy Authority · Phase 2, Interventional, and Treatment
Among 12 studies in Hyperpigmentation with a site in Egypt — 4 open to participants now, 5 under way, 1 of them phase 3. Hyperpigmentation · Egypt.
Among the 12 studies in Hyperpigmentation with a site in Egypt, this one is the 10th largest by enrollment, is one of 3 that started in 2019, is the only one in phase 2, and was the 5th registered.
127 studies on the registry are indexed under Hyperpigmentation; 28 are open to participants now.
This study's enrollment of 20 is below the median of 32 across 113 interventional studies indexed under Hyperpigmentation.
Browse Hyperpigmentation studies →4 of the 12 studies in Hyperpigmentation with a site in Egypt are open now, in 1 country. Each count lists the studies.
Of the 16 Hyperpigmentation studies recruiting now, 8 (50%) set no upper age limit and 8 (50%) stop at 75 or younger; 2 take children under 18; 8 take healthy volunteers.
This study: 36 Years to 57 Years · female · healthy volunteers too.
The full table on the hub →12 studies; the count open now beside each. This study's row is marked.
First in 2019; this study’s year is marked. 3 started in 2019.
Median enrollment 30 across the 12 interventional studies. Of the 6 that completed or were terminated, 0 (0%) have results posted.
None of the 12 has an industry lead sponsor. The 9 most frequent:
Egyptian Atomic Energy Authority is the lead sponsor of 4 studies on the registry; none are open to participants now.
Egyptian Atomic Energy Authority has 1 study filed under Hyperpigmentation — fewer than ten, so there is no comparison to draw.
3 of the studies in Hyperpigmentation with a site in Egypt that are under way reach primary completion within a year, 1 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07810101Phase 3Al-Azhar UniversityEvaluation of the Efficacy of Topical Application of Liquid Nitrogen and Ascorbic Acid in Treatment of Gingival Pigmentation | 2027-02-01 |
| NCT07876921Cairo UniversityMEBO Bio-Dressing on Patient-Reported Outcomes and Tissue Healing Following Rotary Gingival Depigmentation | 2026-12 |
| NCT07402720Cairo UniversityClinical Effectiveness Of Polishing Brush Compared To Ceramic Soft Tissue Trimming Bur In Gingival Depigmentation | 2026-12 |
Among the 12 studies in Hyperpigmentation with a site in Egypt, from their registry updates:
The aim of this work was to assess the efficacy of irradiated amniotic collagen matrix in comparison with platelet rich plasma in facial rejuvenation.The present study included 20 patients with facial wrinkles divided into 2 groups using split face technique: Group (A) subjected to microneedling with amnion gel on the right side of the face . Group (B) subjected to microneedling with PRP on the other side of the face.According to a skin analysis camera (antera camera), there was statistically significant improvement after treatment and between both groups as regard to the roughness(texture) and melanin appeared by Antera camera in which group (A) showed better improvement than group (B). Also, skin biopsies showed improvement in both sides after treatment in which the epidermis was thicker, collagen bundles were broader and thicker than before treatment also elastic fibers were longer, evenly arranged and thicker than before treatment. The patients were followed up over a period of 3 months after the last session with no complications or changes were occurred and the results of sessions were maintained.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
The right side of the split-face was treated by micro-injection of Amnion Collagen
Biological: Amnion collagen
The left side of the split-face was treated by micro-injection of Platelet-rich plasma (PRP)
Biological: Platelet-rich plasma
A collagen extract sourced from the human amniotic membrane
Autologous preparation of PRP
Also known as: PRP
Evaluation of facial wrinkles according to wrinkle severity rate scale (WSRS)
grade 0 = no wrinkles, grade I = just perceptible wrinkle, grade II = shallow wrinkles, grade III = moderately deep wrinkles, grade IV = deep wrinkle with well-defined edges, grade V = very deep wrinkle with redundant fold.
Time frame: 2 weeks
Evaluation of facial wrinkles according to Global Aesthetic Improvement Scale (GAIS)
No improvement or mild improvement less than 25% moderate improvement = 26%-50% marked improvement = 51%-75% excellent improvement = more than 75%
Time frame: 2 weeks
skin pigmentation assessed by skin hyper-pigmentation index
score: No pigmentation=1, sever pigmentation=4
Time frame: 2 weeks
Histopathology improvement of skin biopsy
improved skin structure=1, non-improved skin structure=0
Time frame: 2 weeks
Ran from May 2019 to primary completion in Sep 2021, 28 months.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Oct 2023. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Platelet rich plasma
Egyptian Atomic Energy Authority