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Not yet recruitingNCT06043804Updated Sep 21, 2023

Study on Doppler Ultrasound Measurement of Changes in Uterine Artery Blood Flow in Normal First Trimester Pregnancies and Its Prediction on Abortion

An observational study in Abnormal Uteroplacental Circulation, sponsored by Second Affiliated Hospital of Wenzhou Medical University. Not yet recruiting. Open to female participants aged 16 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-09-21.

Sponsored by Second Affiliated Hospital of Wenzhou Medical University · Observational

From the registry’s dates

  • Primary completion was expected by Dec 2025, 9 months ago, but the record still lists the study as not yet recruiting.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
200
Ages
16 Years to 40 Years
Sex
Female
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Study summary

Objective:To explore the study of Doppler ultrasound in first trimester pregnancies to measure the change of uterine artery blood flow in normal pregnancies and the prediction on abortion, which provides a certain reference for the change trend of uterine artery blood flow in normal first trimester pregnancies and the prediction of Doppler ultrasound measurement in abortion.

Method:Pregnant women who underwent natural conception and single birth prenatal examination in the Obstetrics Department of the Second Affiliated Hospital of Wenzhou Medical University from October 1, 2023 to December 31, 2025 were selected as the study population. Eligible women were preliminarily screened according to the inclusion conditions of the study objects, and basic information of women in each group was compared: Maternal age, gestational time, birth time, gestational week, abortion history, maternal BMI, maternal MAP, smoking status, serum HCG, subchorionic hematoma, fetal bradycardia, left and right uterine aorta pulse index (PI), resistance index (RI) and systolic/diastolic ratio (S/D), etc. To investigate the effect of Doppler ultrasonography on the measurement of uterine artery blood flow in normal pregnancy and the prediction of abortion.

02

Conditions studied

  • Abnormal Uteroplacental Circulation
03

In context

Lead sponsor

Second Affiliated Hospital of Wenzhou Medical University is the lead sponsor of 133 studies on the registry; 44 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
16 Years to 40 Years
Sexes eligible
Female
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

pregnant women

Eligibility criteria

Healthy pregnant women Group

Inclusion Criteria:

  1. Intrauterine pregnancy sac and cardiac activity were confirmed by ultrasound examination at 6 weeks;
  2. Complete maternal clinical data;

Exclusion Criteria:

  1. The level of chorionic gonadotropin (HCG) was static or decreased by ultrasonography;
  2. multiple pregnancy;
  3. Patients with congenital uterine malformations, uterine fibroids and any other uterine disease;
  4. Patients who have chronic diseases or are receiving chronic treatment.

Pregnant women with recurrent pregnancy loss Group

Inclusion Criteria:

  1. Intrauterine pregnancy sac and cardiac activity were confirmed by ultrasound examination at 6 weeks;
  2. Complete maternal clinical data;
  3. There has been a history of spontaneous abortion with the same sexual partner for two or more consecutive times;

Exclusion Criteria:

  1. The level of chorionic gonadotropin (HCG) was static or decreased by ultrasonography;
  2. multiple pregnancy;
  3. Patients with congenital uterine malformations, uterine fibroids and any other uterine disease;
  4. Patients who have chronic diseases or are receiving chronic treatment.
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
200 participants (estimated)
Patient registry
No

Groups and cohorts

  • healthy pregnant woman

    healthy pregnant woman

    Other: Doppler ultrasound measurement of changes in uterine artery blood flow

  • Pregnant women with recurrent pregnancy loss

    Spontaneous abortion of three or more consecutive sexual partners

    Other: Doppler ultrasound measurement of changes in uterine artery blood flow

Interventions

  • OtherDoppler ultrasound measurement of changes in uterine artery blood flow

    Doppler ultrasound measurement of changes in uterine artery blood flow

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What researchers measure

Primary outcomes

  1. Pulsatility index

    Pulsatility index of the left and right main uterine arteries

    Time frame: it can be monitored for up to 12 weeks

  2. Resistive index

    Resistive index of the left and right main uterine arteries

    Time frame: it can be monitored for up to 12 weeks

  3. Systolic-to-diastolic ratio

    Systolic-to-diastolic ratio of the left and right main uterine arteries

    Time frame: it can be monitored for up to 12 weeks

07

Study locations

No study locations are listed for this record.

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 21, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT06043804
Lead sponsor
Second Affiliated Hospital of Wenzhou Medical University
Responsible party
Sponsor
First posted
Sep 21, 2023
Start date
Oct 1, 2023 (estimated)
Primary completion
Dec 31, 2025 (estimated)
Completion
Apr 30, 2026 (estimated)
Last update
Sep 21, 2023

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Sep 2023. You cannot join it, but the record below documents what was studied.

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