An interventional study of Post operative early oral feeding and Traditional delayed oral Feeding Post-perforated Peptic Ulcer Repairs in Peptic Ulcer Perforation, sponsored by Cairo University. Completed at 1 site in Egypt. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-08-29.
Sponsored by Cairo University · Not applicable, Interventional, and Treatment
This study aims to evaluate safety and benefits of early oral feeding compared to traditional delayed oral feeding in patients undergoing perforated peptic ulcer repairs. Study population \& Sample size :(
Study Design:
This study is a single-center, prospective, parallel arm, randomized controlled trial. Patients will be randomly assigned in 1:1 ratio to receive either delayed oral feeding or early oral feeding.
Methods:
Patients will be randomly assigned into two groups. Group A patients followed an early oral feeding protocol(12 hours), and Group B received delayed oral feeding (72 hours).
Outcome parameter :
The outcomes are incidence of postoperative complications including Postoperative repair leakage, Infection-related postoperative complications , Number of days of hospital stay and return of bowel function and Diet intolerance.
21 studies on the registry are indexed under Peptic Ulcer Perforation; 4 are open to participants now.
This study's enrollment of 100 is above the median of 66 across 16 interventional studies indexed under Peptic Ulcer Perforation.
Browse Peptic Ulcer Perforation studies →Cairo University is the lead sponsor of 4,941 studies on the registry; 1,458 are open to participants now.
Of its 37 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
- All consecutive patients, of age 18 years and above, who were
presented to the emergency surgical team and were diagnosed with perforated duodenal ulcer by surgicalteam, were recruited and assessed for eligibility.
Exclusion Criteria:
Preoperative septic shock on admission.
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Relapsed: the illness came back after treatment had worked. Refractory: it did not respond to treatment, or stopped responding while still on it.
A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.
Read whether the line is about a condition or about medicines, and which medicines and doses it means.
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
The human immunodeficiency virus, which weakens the immune system.
Many studies now accept people whose HIV is controlled on treatment, judged by the viral load and the CD4 count. Check the limits this study sets.
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Relapsed and refractory
Relapsed: the illness came back after treatment had worked. Refractory: it did not respond to treatment, or stopped responding while still on it.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Immunosuppression
A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.
Read whether the line is about a condition or about medicines, and which medicines and doses it means.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
HIV
The human immunodeficiency virus, which weakens the immune system.
Many studies now accept people whose HIV is controlled on treatment, judged by the viral load and the CD4 count. Check the limits this study sets.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
ASA physical status
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
early oral intake 6 hours postoperative.
Other: Post operative early oral feeding
delayed oral intake after 72 hours
Other: Traditional delayed oral Feeding Post-perforated Peptic Ulcer Repairs
To start oral feeding 6 hours after perforated peptic ulcer repairs
To start oral feeding after 48 hours
number of days of hospital stay
number of days of hospital stay
Time frame: Up to 10 days
days needed for frist Bowel motion
number of days before frist bowel motion
Time frame: 7 days
incidence of Post operative repair leak
number of Post operative repair leaks
Time frame: 30 days
severity of operative pain measured by Visual Analogue Scale (VAS)
from 1 to 10 1 indicated minimum pain and 10 maximum pain
Time frame: 7 days
INCIDENCE OF postoperative nausea and vomiting (PONAV)
number of cases with postoperative nausea and vomiting (PONAV)
Time frame: 7 days
incidence of Surgical site infection
number of cases complicated with surgical site infection
Time frame: 30 days
incidence of Pulmonary complications
number of cases complicated Pulmonary complications
Time frame: 30 days
incidence of Ryle reinsertion
number of cases complicated Ryle reinsertion
Time frame: 7 days
number of Readmission cases
number of cases complicated Readmission cases
Time frame: 30 days
This study is completed, as verified in Aug 2025. You cannot join it, but the record below documents what was studied.
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