An observational study in Stem Cell Transplant Complications, sponsored by Peking University People's Hospital. Not yet recruiting at 1 site in China. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2023-09-01.
Sponsored by Peking University People's Hospital · Observational
Validation of CARPET prognostic model for septic shock after allo-HSCT: a multicenter, prospective, and cohort study
A clinical prognostic model named CARPET model for septic shock after allo-HSCT has been developed and internally retrospectively validated. A multicenter, prospective cohort study is planned to validate this clinical prediction model again.
The equation of the prediction model for 28-day mortality was as follows:
Probability(28-day mortality)=(exp(Y))/(1+exp(Y)) where Y=2.343+1.328* Time of septic shock- 0.085* Albumin + 0.016 * Bilirubin-0.003*PaO2/FiO2 +0.127*Lactate- 0.011 * Glomerular filtration rate
862 studies on the registry are indexed under Shock, Septic; 207 are open to participants now.
This study's planned enrollment of 200 is above the median of 100 across 298 observational studies indexed under Shock, Septic.
Browse Shock, Septic studies →Peking University People's Hospital is the lead sponsor of 584 studies on the registry; 233 are open to participants now.
Counted across the registry records on this site, refreshed daily.
We included patients diagnosed with septic shock after allo-HSCT. The clinical criteria of septic shock were sepsis as defined by suspected or documented infection and an acute increase of ≥ 2 SOFA points, together with vasopressor therapy (norepinephrine, dopamine, vasopressin, or any other vasopressor) needed to elevate mean arterial pressure ≥ 65 mmHg and lactate >2 mmol/L (18 mg/dL) despite adequate fluid resuscitation.
Exclusion Criteria:
patients who underwent allo-HSCT and experienced septic shock
Other: CARPET prognostic model
For patients diagnosed with septic shock, we obtained the information in CARPET prognostic model including time of septic shock, albumin, bilirubin, PaO2/FiO2, lactate, and GFR. We calculated the CARPET risk score and the 28-day mortality probability according to CARPET logistic regression model.
28-day mortality
Dead or alive at day 28 after septic shock diagnosis
Time frame: 28 days
ICU length of stay
Days in the ICU after septic shock diagnosis
Time frame: up to 1 year
90-day mortality
Dead or alive at day 90 after septic shock diagnosis
Time frame: 90 days
Time on ventilator
Days in need of mechanical ventilation
Time frame: up to 1 year
Plan to share: Yes — Individual anonymised participant data will be made available to researchers upon reasonable request after termination and publication of the study.
Supporting information: Study protocol, Sap, Analytic code
No publications or documents are linked to this record.
This study is not yet recruiting, as verified in Aug 2023. You cannot join it, but the record below documents what was studied.
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Peking University People's Hospital