ClinicalTrials.gg
RecruitingNCT05986799Updated Aug 14, 2023

The Efficacy of Amway Herbal Drink to Improve Skin Anti-aging

An interventional study of Amway Herbal Drink and Placebo Drink in Skin Laxity and Skin Lines, sponsored by Amway (China) R&D Center. Recruiting at 1 site in China. Open to participants aged 30 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-08-14.

Sponsored by Amway (China) R&D Center · Not applicable, Interventional, and Supportive care

From the registry’s dates

  • Primary completion was expected by Nov 2023, 2 years 11 months ago, but the record still lists the study as recruiting.
Phase
Not applicable
Study type
Interventional
Enrollment
30
Allocation
Randomized
Ages
30 Years to 60 Years
Sex
All
01

Study summary

This goal of this two arms, randomized, double-blind controlled trial is to study whether Amway herbal drink could improve skin anti-aging in the middle-aged people of 30-60 years old. The main questions it aims to answer are:

  1. whether skin elasticity will be improved measured by Cutometer
  2. whether skin wrinkles/roughness/pores will be improved measured by Antera 3D

30 eligible Participants will be enrolled in one center and randomly assigned to two study groups (Amway herbal drink group and placebo drink group). Up to four study visits will be made by the subject over a 3-month period intervention and all clinical data will be captured and recorded into CTMS (Clinical Trial Management System) for data analysis and reporting.

Researchers will compare Amway herbal drink group and placebo drink group to see if consumption of Amway herbal drink could significantly improve skin anti-aging at the end of the study.

02

Conditions studied

  • Skin Laxity
  • Skin Lines

Keywords

  • Anti-aging
  • Amway herbal drink
03

In context

Lead sponsor

Amway (China) R&D Center is the lead sponsor of 9 studies on the registry; 3 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
30 Years to 60 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Male and female subjects, aged 30 to 60 years, with a gender ratio of 3:7;
  • Subjects are healthy;
  • Visual assessment, smoothness is greater than or equal to 3 points (according to the Test Method of Efficacy Measurement of Nourishing Cosmetic Products issued by Chinese Association of Fragrance Flavor and Cosmetic Industries, the smaller the index, the better. Please refer to appendix II);
  • Visual assessment, the gloss index is greater than or equal to 4 points (according to the Unilever Radiance Scale, the smaller the index is the better. Please refer to appendix III);
  • Subjects could not use facial whitening and moisturizing products during the trial;
  • Agree not to take other oral products with similar efficacy (such as collagen, sodium hyaluronate, etc.) during the trial. During the trial, participants agreed not to take any drugs or supplements. Do not do any medical beauty projects during the trial, do not participate in other interventional clinical research;
  • Have a full understanding of the purpose, benefits, and possible risks and side effects of the study;
  • Willing to comply with all research requirements and procedures;
  • Understand the test procedure, read, and sign an appropriate Form indicating their willingness to participate.

Exclusion criteria

Exclusion Criteria:

  • Use of any medications or supplements that may alter skin properties during the first 3 months of enrollment;
  • Skin disease patients;
  • Ggastrointestinal symptoms being treated;
  • Lactose intolerance, allergy to fish and its products;
  • Present with other organic diseases that affect intestinal function, such as history of gastrointestinal resection, colon or rectal cancer, inflammatory bowel disease, diabetes, hyperthyroidism or hypothyroidism, congenital megacolon, scleroderma, anorexia nervosa, etc.;
  • Controlling diet, exercising more, or taking medications to control weight or affect appetite in the last 3 months;
  • Subjects have any of the following medical history or clinical findings that may affect the evaluation of the trial effect: significant gastrointestinal disorders, liver, kidney, endocrine, hematological, respiratory and cardiovascular diseases;
  • Abuse of alcohol or other illicit drugs, supplements currently or in the past, or OTC prescription drugs that may cause intestinal dysfunction or interfere with the evaluation of trial effects;
  • Frequent use of drugs that may affect gastrointestinal function or the immune system, as judged by the researcher;
  • Use of laxatives or other digestive substances in the 2 weeks prior to trial commencement;
  • Women who are pregnant or breastfeeding, or who plan to become pregnant during the trial;
  • PI considers that volunteers cannot fully cooperate with the trial arrangement.
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

05

Study design

Phase
Not applicable
Primary purpose
Supportive care
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Investigator)
Enrollment
30 participants (estimated)

Study arms

  • Active comparator
    Amway Herbal Drink

    Amway Herbal Drink: 5g/sachet, containing the following active ingredients: * Extract of Phyllanthus emblica * Sophora flower extract * Wild cherry extract * Flower extract of Dendrobium candidum * Pomegranate extract * Resistant dextrin * γ-cyclodextrin

    Dietary Supplement: Amway Herbal Drink

  • Placebo comparator
    Placebo Drink

    Placebo Drink: 5g/sachet, containing the following active ingredients: * Maltodextrin * Sugar * Honey

    Dietary Supplement: Placebo Drink

Interventions

  • Dietary supplementAmway Herbal Drink

    1 sachet per time, 3 times daily, for 3 months period.

  • Dietary supplementPlacebo Drink

    1 sachet per time, 3 times daily, for 3 months period.

06

What researchers measure

Primary outcomes

  1. Change of Skin Elasticity

    The changes of skin elasticity from baseline to day 90 by CK Cutometer MPA580

    Time frame: baseline day 0, day 90

Secondary outcomes

  1. Change of Facial Lines/Wrinkles

    The changes of facial lines/wrinkles by Miravex Antera 3D imaging system

    Time frame: baseline day 0, day 45, day 90

07

Study locations

1 of 1 sites recruiting
  • Ai You Mei Medical Beauty Clinic
    Jinhua, Zhejiang, China
    Recruiting
08

References and documents

Publications

  • Cao C, Xiao Z, Wu Y, Ge C. Diet and Skin Aging-From the Perspective of Food Nutrition. Nutrients. 2020 Mar 24;12(3):870. doi: 10.3390/nu12030870. PubMed 32213934 ↗
  • Blanpain C, Fuchs E. Epidermal stem cells of the skin. Annu Rev Cell Dev Biol. 2006;22:339-73. doi: 10.1146/annurev.cellbio.22.010305.104357. PubMed 16824012 ↗
  • Zhang S, Duan E. Fighting against Skin Aging: The Way from Bench to Bedside. Cell Transplant. 2018 May;27(5):729-738. doi: 10.1177/0963689717725755. Epub 2018 Apr 25. PubMed 29692196 ↗
  • Blume-Peytavi U, Kottner J, Sterry W, Hodin MW, Griffiths TW, Watson RE, Hay RJ, Griffiths CE. Age-Associated Skin Conditions and Diseases: Current Perspectives and Future Options. Gerontologist. 2016 Apr;56 Suppl 2:S230-42. doi: 10.1093/geront/gnw003. PubMed 26994263 ↗
  • Michalak M. Plant-Derived Antioxidants: Significance in Skin Health and the Ageing Process. Int J Mol Sci. 2022 Jan 6;23(2):585. doi: 10.3390/ijms23020585. PubMed 35054770 ↗
  • Fam VW, Charoenwoodhipong P, Sivamani RK, Holt RR, Keen CL, Hackman RM. Plant-Based Foods for Skin Health: A Narrative Review. J Acad Nutr Diet. 2022 Mar;122(3):614-629. doi: 10.1016/j.jand.2021.10.024. Epub 2021 Oct 30. PubMed 34728412 ↗
  • Chaikul P, Kanlayavattanakul M, Somkumnerd J, Lourith N. Phyllanthus emblica L. (amla) branch: A safe and effective ingredient against skin aging. J Tradit Complement Med. 2021 Feb 9;11(5):390-399. doi: 10.1016/j.jtcme.2021.02.004. eCollection 2021 Sep. PubMed 34522633 ↗
  • Binic I, Lazarevic V, Ljubenovic M, Mojsa J, Sokolovic D. Skin ageing: natural weapons and strategies. Evid Based Complement Alternat Med. 2013;2013:827248. doi: 10.1155/2013/827248. Epub 2013 Jan 29. PubMed 23431351 ↗
  • Lee HR, Ryu HG, Lee Y, Park JA, Kim S, Lee CE, Jung S, Lee KH. Effect of Aronia Extract on Collagen Synthesis in Human Skin Cell and Dermal Equivalent. Oxid Med Cell Longev. 2022 Aug 8;2022:4392256. doi: 10.1155/2022/4392256. eCollection 2022. PubMed 35979399 ↗
  • Benatrehina PA, Pan L, Naman CB, Li J, Kinghorn AD. Usage, biological activity, and safety of selected botanical dietary supplements consumed in the United States. J Tradit Complement Med. 2018 Mar 2;8(2):267-277. doi: 10.1016/j.jtcme.2018.01.006. eCollection 2018 Apr. PubMed 29736381 ↗
  • Zhou H, Zhou L, Li B, Yue R. Anti-cyclooxygenase, anti-glycation, and anti-skin aging effect of Dendrobium officinale flowers' aqueous extract and its phytochemical validation in aging. Front Immunol. 2023 Mar 17;14:1095848. doi: 10.3389/fimmu.2023.1095848. eCollection 2023. PubMed 37006297 ↗

Individual participant data

Plan to share: No

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 14, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05986799
Lead sponsor
Amway (China) R&D Center
Responsible party
Sponsor
First posted
Aug 14, 2023
Start date
Aug 13, 2023 (estimated)
Primary completion
Nov 15, 2023 (estimated)
Completion
Nov 30, 2023 (estimated)
Last update
Aug 14, 2023

Study contacts

Charlie Zhang, MD
Contact
charlie.zhang@sprimmedical.com
+8613901981272
Yun Wang, MD
principal investigator · Shanghai Jiao Tong University School of Medicine

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Interested in this study?

Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.

Contact study team

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion