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CompletedNCT05978583Updated Dec 15, 2025

Impact of Physical and Occupational Therapy in New BMT Patients

An observational study in Bone Marrow Transplantation and Bone Marrow Disease, sponsored by UNC Lineberger Comprehensive Cancer Center. Completed at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-12-15.

Sponsored by UNC Lineberger Comprehensive Cancer Center · Observational

Study type
Observational
Model
Cohort
Time perspective
Cross-sectional
Enrollment
75
Ages
18 Years and older
Sex
All
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Study summary

This is a single-site, non-randomized, observational study designed to evaluate the impact of adding physical and occupational therapy consultation upon inpatient admission for a bone marrow transplantation (BMT). The purpose of this study is to investigate whether consultation with physical and occupational therapists as part of the general admission order set for patients scheduled for bone marrow transplant will result in reduced complications, morbidity, length of inpatient stay, 30-day readmission, and 90-day mortality. Baseline data collection will be used to determine eligibility. This study will be partially retrospective (pre-implementation of physical and occupational therapy consultation order) and partially prospective.

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Conditions studied

  • Bone Marrow Transplantation
  • Bone Marrow Disease

Keywords

  • exercise
  • physical therapy
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In context

Bone Marrow Diseases

200 studies on the registry are indexed under Bone Marrow Diseases; 34 are open to participants now.

This study's enrollment of 75 is close to the median of 80 across 59 observational studies indexed under Bone Marrow Diseases.

Browse Bone Marrow Diseases studies →

Lead sponsor

UNC Lineberger Comprehensive Cancer Center is the lead sponsor of 414 studies on the registry; 96 are open to participants now.

Of its 32 completed or terminated interventional studies of FDA-regulated products, 25 (78%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Subjects who are admitted for bone marrow transplantation (BMT) at the study site.

Inclusion criteria

  1. Age ≥ 18 years at the time of admission for bone marrow transplantation (BMT)
  2. Received BMT

Exclusion criteria

Exclusion Criteria:

1. No history of inpatient admission for BMT

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Study design

Observational model
Cohort
Time perspective
Cross-sectional
Enrollment
75 participants (actual)
Patient registry
No

Groups and cohorts

  • physical and occupational therapy

    Physical and occupational therapy consultation might be used to provide targeted prehabilitation interventions.

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What researchers measure

Primary outcomes

  1. 30-day readmission

    30-day readmission rates will be calculated using historical data (pre-intervention) and compared to rates once physical and occupational therapy consultation has been included in the inpatient admission order set for bone marrow transplantation (BMT).

    Time frame: Up to 30 days after bone marrow transplantation

Secondary outcomes

  1. The feasibility

    The proportion of individuals who received a physical and occupational therapy consultation in the prospective group.

    Time frame: 1 day (the date of bone marrow transplantation)

  2. Acute care length of stay

    Acute care length of stay will be calculated using historical data (pre-intervention) and compared to rates once physical and occupational therapy consultation has been included in the inpatient admission order set for BMT.

    Time frame: Up to 90 days after bone marrow transplantation

  3. Mortality rates

    Mortality rates will be calculated by comparing, how many subjects died pre-intervention and post-intervention, using medical record data.

    Time frame: Up to 90 days after bone marrow transplantation

  4. Complication types and rates

    Complication types and rates will be calculated and compared pre-intervention and post-intervention using medical record data.

    Time frame: Up to 90 days after bone marrow transplantation

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Study locations

1 site
  • Lineberger Comphrehensive Cancer Center at University of North Carolina at Chapel Hill
    Chapel Hill, North Carolina 27599, United States
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References and documents

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 15, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT05978583
Lead sponsor
UNC Lineberger Comprehensive Cancer Center
Responsible party
Sponsor
First posted
Aug 7, 2023
Start date
Jan 1, 2023
Primary completion
Dec 4, 2024
Completion
Dec 4, 2024
Last update
Dec 15, 2025

Study contacts

Sasha Stephen, MD
principal investigator · UNC Lineberger Comprehensive Cancer Center

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Dec 2025. You cannot join it, but the record below documents what was studied.

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