An interventional study of exercise in Obesity and Exercise, sponsored by University of Missouri-Columbia. Withdrawn at 1 site in United States. Open to participants aged 21 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-10-01.
Sponsored by University of Missouri-Columbia · Not applicable, Interventional, and Basic science
Regular exercise participation is known to reduce cardiometabolic disease risk but the impact that exercise training has on adipose tissue (AT) metabolism is poorly understood, particularly in humans. It is well established that exercise training improves whole-body glucose levels and increases insulin sensitivity, and this can occur within one or two weeks. These effects are usually due to adaptations in skeletal muscle, the tissue responsible for the majority of glucose disposal. However, many studies have now determined that exercise training also results in adaptations in AT that improve whole-body metabolic health by improving glucose uptake into the AT.
Skeletal muscle is thought to account for approximately 75-85% of glucose uptake , and this process is impaired in .individuals who are insulin-resistant state. It is postulated that the increased level of adiposity that accompanies severe obesity would result in higher dependency on AT for glucose uptake as the AT would be a bigger "sink". Thus the role of AT in inducing whole body insulin resistance is still unclear, particularly in individuals with obesity.
This study will examine the changes in AT glucose uptake before and after 4 weeks of exercise training in obese individuals and establish if there are sex differences.
1,960 studies on the registry are indexed under Insulin Resistance; 306 are open to participants now.
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Of its 42 completed or terminated interventional studies of FDA-regulated products, 28 (67%) have results posted.
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Exclusion Criteria:
All subjects will undergo exercise training for 4 wks. 45-60 min of exercise, 4 sessions/wk supervised, 1 session unsupervised. intensity 60% of VO2 max
Behavioral: exercise
All subjects will undergo exercise training for 4 wks. 45-60 min of exercise, 4 sessions/wk supervised, 1 session unsupervised. intensity 60% of VO2 max
GLUT4 protein expression
protein expression
Time frame: 4 weeks
TB1CD4 protein expression
TB1CD4 protein expression
Time frame: 4 weeks
percent body fat
Body fat will be measured using DEXA pre and post training
Time frame: 4 weeks
This study is withdrawn, as verified in Sep 2024. You cannot join it, but the record below documents what was studied.
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University of Missouri-Columbia