An observational study in Metabolic Disease, Cardiovascular Diseases and Healthy Aging, sponsored by Westlake University. Withdrawn at 2 sites in China. Open to participants aged 6 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-06-13.
Sponsored by Westlake University · Observational
This project aims to explore the relationship between healthy lifespan and nutrition through a 10-year longitudinal study in Zhejiang Province. The cohort will include individuals in a wide range of age groups. The demographic, diet, lifestyle information, health status, and corresponding bio-samples will be collected carefully. It will give a deeper insight to the relation between nutrition and healthy aging and longevity. Ultimately, this research will contribute to evidence-based nutrition interventions to improve health outcomes and enhance quality of life.
This project aims to elucidate the relationship between healthy lifespan and nutrition through the establishment of a large-scale cohort of participants and longitudinal follow-ups spanning around 10 years in Zhejiang Province. The cohort will comprise individuals in a wide range of age groups starting at 6 years old. The participants will provide demographic information, anthropometry measurements, detailed diet, lifestyle data and health status, including 3-day dietary records and long-term food intake frequency recalls. Integrated with previous information, diverse bio-samples will also be collected to establish a multi-dimensional biobank. It will give a deeper insight to the relation between nutrition and healthy aging and longevity. Ultimately, this research will contribute to the development of evidence-based nutrition designed to improve health outcomes and enhance the quality of life for individuals of all ages.
4,904 studies on the registry are indexed under Cardiovascular Diseases; 919 are open to participants now.
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Permanent residents in Zhejiang Province
Exclusion Criteria:
Occurrence of cardio-metabolic diseases
The investigators will track for occurrence of cardio-metabolic diseases by follow-up surveys collected by the Zhejiang Center for Disease Control and Prevention.
Time frame: up to 10 years
Changes in fasting blood glucose
Fasting glucose will be examined in mmol/L.
Time frame: Every other year， up to 10 years
Changes in fasting blood HbA1c
Fasting blood HbA1c will be examined in %
Time frame: Every other year， up to 10 years
Changes in fasting lipid metabolism
Triglyceride, cholesterol, high density lipoprotein cholesterol and low density lipoprotein cholesterol will be examined in mmol/L.
Time frame: Every other year， up to 10 years
Changes in fasting blood highly sensitive C-reactive protein (CRP)
CRP will be examined in mg/L.
Time frame: Every other year， up to 10 years
Changes in body mass index
Body mass index (BMI) will be calculated in kg/m\^2
Time frame: Every other year， up to 10 years
Changes in blood pressure
Blood pressure, including systolic and diastolic blood pressure, will be measured in mmHg
Time frame: Every other year， up to 10 years
Changes in gut microbiome profiling
16S rRNA and/or shotgun metagenomic sequencing will be performed in stool samples.
Time frame: Every other year， up to 10 years
This study is withdrawn, as verified in May 2025. You cannot join it, but the record below documents what was studied.
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Westlake University