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CompletedNCT05911490Updated Jun 22, 2023

Effects of Breaking Sitting on Human Behaviour and Metabolic Health

An interventional study of Prolonged sitting and Breaking prolonged sitting in Energy Balance, Physical Activity Level and Cognition, sponsored by National Taiwan Normal University. Completed at 1 site in Taiwan. Open to participants aged 20 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-06-22.

Sponsored by National Taiwan Normal University · Not applicable, Interventional, and Basic science

From the registry’s dates

  • Registered 3 years 5 months after the study started (first participant enrolled Dec 2019, registered May 2023).
Phase
Not applicable
Study type
Interventional
Enrollment
24
Allocation
Randomized
Ages
20 Years to 45 Years
Sex
All
01

Study summary

This study primarily aimed to investigate effects of breaking up prolonged sitting with intermittent brisk walking in healthy young individuals on (1) post-trial human behaviours including energy intake and physical activity under free-living conditions and (2) cognitive performance in a simulated workplace environment.

02

Conditions studied

  • Energy Balance
  • Physical Activity Level
  • Cognition
  • Metabolic Health

Keywords

  • Breaking up sitting
  • Eating behaviour
  • Spontaneous physical activity
  • Executive function
  • Energy balance
03

In context

Lead sponsor

National Taiwan Normal University is the lead sponsor of 62 studies on the registry; 15 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
20 Years to 45 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Without current and any history of brain injury, neurological disorder, cardiometabolic related diseases, diabetes or cancers.
  • Weight stable (not self-reported weight change ± 3 kg at least 3 months)
  • Body mass index (BMI) ranging between 18.5 to 27 kg/m2
  • Can walk safely on a treadmill

Exclusion criteria

Exclusion Criteria:

  • Smokers, post-menopausal female, and volunteers who used any medications that could influence metabolic and inflammatory responses.
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Crossover assignment
Masking
None (open label)
Enrollment
24 participants (actual)

Study arms

  • Active comparator
    Prolonged sitting

    Participants sat on a chair during the trial in the laboratory.

    Behavioral: Prolonged sitting

  • Experimental
    Breaking prolonged sitting

    Participants walked regularly during the trial in the laboratory.

    Behavioral: Breaking prolonged sitting

Interventions

  • BehavioralProlonged sitting

    In the laboratory, after consuming 1st meal, participants sat on a chair for 180 min. After 180 min, the 2nd meal was provided. After finishing the 2nd meal, participants sat on a chair for another 120 min. After data collection was completed in the laboratory, participants were asked to keep wearing the same pedometer and to record any food and liquid consumption for the rest of the day (until midnight) under free-living conditions.

  • BehavioralBreaking prolonged sitting

    In the laboratory, after consuming 1st meal, participants walked 2 min on a treadmill every 20 minutes for the following 180 min. For the remainder of the time participants sat on the chair. After 180 min, the 2nd meal was provided. After finishing the 2nd meal, participants continued 2 min of walking every 20 min for the following 120 min. After data collection was completed in the laboratory, participants were asked to keep wearing the same pedometer and to record any food and liquid consumption for the rest of the day (until midnight) under free-living conditions.

06

What researchers measure

Primary outcomes

  1. Physical activity level

    Changes in physical activity level (steps) in the free-living conditions

    Time frame: 480 minutes

  2. Energy intake

    Changes in energy intake (kcal) in the free-living conditions

    Time frame: 480 minutes

  3. Cognitive performance

    Changes in cognitive performance (% changes in accuracy) including Task Switching and Flanker tasks

    Time frame: 320 minutes

  4. Cognitive function

    Changes in cognitive performance (% changes in reaction time) Task Switching and Flanker tasks

    Time frame: 320 minutes

Secondary outcomes

  1. Postprandial glucose concentrations

    Changes in postprandial finger pricking glucose concentrations

    Time frame: 320 minutes

  2. Blood pressure

    Changes in systolic blood pressure and diastolic blood pressure

    Time frame: 320 minutes

  3. Visual analogue scale (VAS)

    Changes in self-perceived sensations including appetite, energy and mood (score from 0-100)

    Time frame: 320 minutes

  4. Continuous glucose monitoring

    Changes in different depots of adipose tissue interstitial glucose concentrations

    Time frame: 320 minutes

07

Study locations

1 site
  • National Taiwan Normal University
    Taipei, Taiwan
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 22, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05911490
Lead sponsor
National Taiwan Normal University
Collaborators
Division of Endocrinology and Metabolism, Tri-Service General Hospital
Responsible party
Yung-Chih Chen (Principal Investigator, National Taiwan Normal University) — Principal investigator
First posted
Jun 22, 2023
Start date
Dec 20, 2019
Primary completion
Sep 29, 2020
Completion
Sep 29, 2020
Last update
Jun 22, 2023

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Jun 2023. You cannot join it, but the record below documents what was studied.

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