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Active, not recruitingNCT05906420Updated Apr 8, 2025

Posterior Circulation ASTRAL Prognostic Score

An observational study in Stroke Ischemic, Stroke Acute and Posterior Circulation Brain Infarction, sponsored by University of Thessaly. Active, not recruiting at 2 sites in 2 countries. Per ClinicalTrials.gov, last updated 2025-04-08.

Sponsored by University of Thessaly · Observational

Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
2,000
Sex
All
01

Study summary

The goal of this study is to develop a prognostic score for ischemic posterior circulation strokes, based on our previous work on with the ASTRAL scores (Acute STroke Registry and Analysis of Lausanne) on overall stroke prognosis, intracranial occlusion, recanalization and stroke recurrences. The main question it aims to answer is the modified Rankin score in 3 months after the event.

Participants will be patients with acute ischemic stroke of the posterior circulation with mRS priot to event \<3. All the data will be collected retrospectively from patients included in the ASTRAL registry between January 2003 and December 2021. The ASTRAL registry will be used as the derivation cohort of the score. Demographics, acute glucose, NIHSS score and acute imaging of each participant will be used from the derivation cohort in order to create an integer-based prognostic score. After internal validation, we plan to validate the score in external stroke registries to show its validity.

02

Conditions studied

  • Stroke Ischemic
  • Stroke Acute
  • Posterior Circulation Brain Infarction
  • Risk Score
03

In context

Ischemic Stroke

2,612 studies on the registry are indexed under Ischemic Stroke; 971 are open to participants now.

This study's planned enrollment of 2,000 is above the median of 300 across 771 observational studies indexed under Ischemic Stroke.

Browse Ischemic Stroke studies →

Lead sponsor

University of Thessaly is the lead sponsor of 195 studies on the registry; 44 are open to participants now.

Browse University of Thessaly studies →

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

The participants included in this study are exclusively patients with acute ischemic stroke of the posterior circulation arriving at the hospital within 24h since last proof of good health. These patients must have a modified Rankin Score \<3 prior the event and available data concerning: age, NIHSS, glucose levels at admission, mRS prior to event and 3 months after the event and acute phase imaging characteristics (CT and/or MRI) including large vessel occlusion, leukoaraiosis and ASPECTS score from the acute CT scan.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Isolated posterior circulation strokes based on clinical or/and imaging evidence.
  • Arriving within 24h at hospital since last proof of good health.

Exclusion criteria

Exclusion Criteria:

  • no available data for 3 months modified Rankin Score
  • modified Rankin Score≥3 prior the event
05

Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
2,000 participants (estimated)
Patient registry
No

Groups and cohorts

  • ASTRAL

    Diagnostic Test: ASTRAL prognostic score

  • Basel cohort

    Diagnostic Test: ASTRAL prognostic score

  • Berlin cohort

    Diagnostic Test: ASTRAL prognostic score

  • Bern Cohort

    Diagnostic Test: ASTRAL prognostic score

  • Bologna cohort

    Diagnostic Test: ASTRAL prognostic score

  • Dijon cohort

    Diagnostic Test: ASTRAL prognostic score

  • Lisbon cohort

    Diagnostic Test: ASTRAL prognostic score

  • Israel cohort

    Diagnostic Test: ASTRAL prognostic score

  • Innsbruck cohort

    Diagnostic Test: ASTRAL prognostic score

  • St. Gallen cohort

    Diagnostic Test: ASTRAL prognostic score

  • Lugano cohort

    Diagnostic Test: ASTRAL prognostic score

  • Chicago cohort

    Diagnostic Test: ASTRAL prognostic score

  • West Virginia cohort

    Diagnostic Test: ASTRAL prognostic score

  • Zurich cohort

    Diagnostic Test: ASTRAL prognostic score

  • Seoul cohort

    Diagnostic Test: ASTRAL prognostic score

Interventions

  • Diagnostic testASTRAL prognostic score

    ASTRAL prognostic score

06

What researchers measure

Primary outcomes

  1. 3 months modified Ranking scale

    evaluation of 3 months neurological disability

    Time frame: January 2003-December 2021

07

Study locations

2 sites
  • First Propedeutic Department of Internal Medicine & Stroke Unit, AHEPA University Hospital, Aristotle University of Thessaloniki
    Thessaloniki, Central Macedonia 54636, Greece
  • Stroke Center, Department of clinical neurosciences, Lausanne University Hospital and University of Lausanne
    Lausanne, Vaud canton 1011, Switzerland
08

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Ran from Jan 2003 to primary completion in Dec 2021, 227 months.

How these figures are worked out, and which studies are left out of them.

Registered
Jun 6, 2023
First posted
Jun 15, 2023
StartActual
Jan 1, 2003
Primary completionActual
Dec 31, 2021
CompletionEst.
Nov 24, 2025
Last update
Apr 8, 2025
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Apr 8, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT05906420
Lead sponsor
University of Thessaly
Collaborators
University of Lausanne, Centre Hospitalier Universitaire Vaudois
Responsible party
George Ntaios (Professor of Internal Medicine George Ntaios, Aristotle University Of Thessaloniki) — Principal investigator
First posted
Jun 15, 2023
Start date
Jan 1, 2003
Primary completion
Dec 31, 2021
Completion
Nov 24, 2025 (estimated)
Last update
Apr 8, 2025

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is active, not recruiting, as verified in Apr 2025. You cannot join it, but the record below documents what was studied.

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Discussion

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