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RecruitingNCT05869370TBFRUpdated May 22, 2023

The Effects Of Low Intensity Training With Blood Flow Restriction In Rheumatoid Arthritis Patients

An interventional study of High intensity resistance training and Low intensity resistance training combined with blood flow restriction in Rheumatoid Arthritis, sponsored by Federal University of Rio Grande do Sul. Recruiting at 1 site in Brazil. Open to female participants aged 45 Years to 65 Years. Per ClinicalTrials.gov, last updated 2023-05-22.

Sponsored by Federal University of Rio Grande do Sul · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Primary completion was expected by Dec 2025, 10 months ago, but the record still lists the study as recruiting.
  • Registered 4 years 11 months after the study started (first participant enrolled May 2018, registered May 2023).
  • Started May 2018; still recruiting 8 years 4 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
28
Allocation
Randomized
Ages
45 Years to 65 Years
Sex
Female
01

Study summary

Rheumatoid arthritis (RA) patients showed systemic manifestations that may lead to a reduction in muscle strength, muscle mass and, consequently, to a reduction in physical function. On the other hand, high intensity resistance training (HIRT) are able to improve muscle strength and muscle mass in RA without affecting the disease course. However, due to the articular manifestations caused by this disease, these patients may present intolerance to HIRT. Thus, the low intensity resistance training with blood flow restriction (TBFR) may be a new training strategy for these populations. In this sense, the investigators speculate that TBFR could be beneficial in RA patients, as well as, HIRT.

02

Conditions studied

  • Rheumatoid Arthritis

Keywords

  • Rheumatoid Arthritis
  • Kaatsu
  • Blood Flow Restriction Training
03

In context

Arthritis

3,554 studies on the registry are indexed under Arthritis; 317 are open to participants now.

This study's planned enrollment of 28 is below the median of 90 across 2,377 interventional studies indexed under Arthritis.

Browse Arthritis studies →

Lead sponsor

Federal University of Rio Grande do Sul is the lead sponsor of 118 studies on the registry; 20 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
45 Years to 65 Years
Sexes eligible
Female
Accepts healthy volunteers
No

Inclusion criteria

  • Female;
  • Rheumatoid arthritis patients;
  • All individuals will undergo an ergospirometry to ensure cardiorespiratory conditions.

Exclusion criteria

Exclusion Criteria:

  • Fibromyalgia;
  • Cardiovascular disease;
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
28 participants (estimated)

Study arms

  • Experimental
    High intensity resistance training

    Other: High intensity resistance training

  • Experimental
    Low intensity resistance training combined with blood flow restriction

    Other: Low intensity resistance training combined with blood flow restriction

Interventions

  • OtherHigh intensity resistance training

    Twelve weeks of resistance training twice a week.

  • OtherLow intensity resistance training combined with blood flow restriction

    Twelve weeks of resistance training with blood flow restriction twice a week.

06

What researchers measure

Primary outcomes

  1. Muscle strength

    1 maximum repetition test.

    Time frame: Twelve weeks

07

Study locations

1 of 1 sites recruiting
  • Universidade Federal do Rio Grande do Sul - Faculdade de Medicina - Hospital de Clínicas de Porto Alegre
    Porto Alegre, Rio Grande Do Sul, Brazil
    • Leonardo P. dos Santos, Master's degree · Contact · leonardosantos@hcpa.edu.br · +55 (51)9 92840819
    • Rafaela C.E. Santo, PhD · Sub investigator
    • Ricardo M. Xavier, PhD · Principal investigator
    Recruiting
08

References and documents

Publications

  • Dos Santos LP, Santo RCDE, Ramis TR, Portes JKS, Chakr RMDS, Xavier RM. The effects of resistance training with blood flow restriction on muscle strength, muscle hypertrophy and functionality in patients with osteoarthritis and rheumatoid arthritis: A systematic review with meta-analysis. PLoS One. 2021 Nov 10;16(11):e0259574. doi: 10.1371/journal.pone.0259574. eCollection 2021. PubMed 34758045 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 22, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05869370
Lead sponsor
Federal University of Rio Grande do Sul
Collaborators
Hospital de Clínicas de Porto Alegre
Responsible party
Ricardo Machado Xavier (PhD, Federal University of Rio Grande do Sul) — Principal investigator
First posted
May 22, 2023
Start date
May 20, 2018
Primary completion
Dec 2025 (estimated)
Completion
Dec 2025 (estimated)
Last update
May 22, 2023

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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