An interventional study of APA and PAE in Neurocognitive Disorders, sponsored by Centre Hospitalier Universitaire de Nice. Completed at 1 site in France. Open to participants aged 70 Years and older. Per ClinicalTrials.gov, last updated 2026-06-29.
Sponsored by Centre Hospitalier Universitaire de Nice · Not applicable, Interventional, and Other
This study aims to compare the effect of a program of Adapted Physical Activity (APA) versus the same program combined with a physical activity education program (PAE). Patients suffering from neurocognitive disorders (mild or early major) will be randomized into one of the two conditions. 3 complete evaluations will be done (inclusion M0, after 3 month of intervention M3, 3 months after the end of the intervention M6). The team except that APA+PEA will be more effectiv than the APA solely, on the following criteria : level of physical activity, cogntive function and quality of life.
246 studies on the registry are indexed under Neurocognitive Disorders; 88 are open to participants now.
This study's enrollment of 30 is below the median of 72 across 150 interventional studies indexed under Neurocognitive Disorders.
Browse Neurocognitive Disorders studies →Centre Hospitalier Universitaire de Nice is the lead sponsor of 709 studies on the registry; 176 are open to participants now.
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Exclusion Criteria:
24 APA sessions will take place, there will be 2 sessions a week for 12 weeks which will include global exercises for the upper and lower limb. One session will be 1 hour long and supervised by professionals. It will be divided in 4 cycles which will be differentiated by the intensity of its components: aerobic, strength, speed, balance, coordination and flexibility. The intensity of the sessions will be measured by RPE and heart rate monitor,
Other: APA
24 APA sessions will take place, there will be 2 sessions a week for 12 weeks which will include global exercises for the upper and lower limb. One session will be 1 hour long and supervised by professionals. It will be divided in 4 cycles which will be differentiated by the intensity of its components: aerobic, strength, speed, balance, coordination and flexibility. The intensity of the sessions will be measured by RPE and heart rate monitor, \+ 8 individuals sessions of PAE (one per week, half an hour long) that will consist of advising and setting weekly goals related to improving PA level and sedentary behavior
Other: APA · Other: PAE
24 APA sessions
8 individuals sessions of PAE
physical activity level
evolution of physical activity level will be assessed by actimetry on a 7 days period mesured by IPAQ score
Time frame: at inclusion
physical activity level
evolution of physical activity level will be assessed by actimetry on a 7 days period mesured by IPAQ score
Time frame: at 3 months after inclusion
physical activity level
evolution of physical activity level will be assessed by actimetry on a 7 days period mesured by IPAQ score
Time frame: at 6 months after inclusion
global cognition
global cognition will be assessed by a MMSE test (Mini Mental State Examination) mesured by a score
Time frame: at inclusion
global cognition
global cognition will be assessed by a MMSE test (Mini Mental State Examination) mesured by a score
Time frame: at 3 months after inclusion
global cognition
global cognition will be assessed by a MMSE test (Mini Mental State Examination) mesured by a score
Time frame: at 6 months after inclusion
executive functions
executiv functions will be assessed by FAB (frontal assessment battery)
Time frame: at inclusion
executive functions
executiv functions will be assessed by FAB (frontal assessment battery)
Time frame: at 3 months after inclusion
executive functions
executiv functions will be assessed by FAB (frontal assessment battery)
Time frame: at 6 months after inclusion
executive functions (FAB)
executiv functions will be assessed by FAB (frontal assessment battery) giving a score
Time frame: at inclusion
executive functions (FAB)
executiv functions will be assessed by FAB (frontal assessment battery) giving a score
Time frame: at 3 months after inclusion
executive functions (FAB)
executiv functions will be assessed by FAB (frontal assessment battery) giving a score
Time frame: at 6 months after inclusion
executive functions (TMT)
executiv functions will be assessed by TMT (frontal assessment battery) - giving a score
Time frame: at inclusion
executive functions (TMT)
executiv functions will be assessed by TMT (frontal assessment battery) - giving a score
Time frame: at 3 months after inclusion
executive functions (TMT)
executiv functions will be assessed by TMT (frontal assessment battery) - giving a score
Time frame: at 6 months after inclusion
cardiovascular performance
Cardiovascular performance will be evaluated through a effort test that will be performed on a stationary bicycle ergometer connected to a portable gas exchange analysis system in ml/kg/min
Time frame: at inclusion
cardiovascular performance
Cardiovascular performance will be evaluated through a effort test that will be performed on a stationary bicycle ergometer connected to a portable gas exchange analysis system in ml/kg/min
Time frame: at 3 months after inclusion
cardiovascular performance
Cardiovascular performance will be evaluated through a effort test that will be performed on a stationary bicycle ergometer connected to a portable gas exchange analysis system in ml/kg/min
Time frame: at 6 months after inclusion
power - physical condition
physical condition will be asessed by lower extremity power (isokinetic ergometer) with a score
Time frame: at inclusion
power - physical condition
physical condition will be asessed by lower extremity power (isokinetic ergometer) with a score
Time frame: at 3 months after inclusion
power - physical condition
physical condition will be asessed by lower extremity power (isokinetic ergometer) with a score
Time frame: at 6 months after inclusion
strenght - physical condition
physical condition will be asessed by grip strength (hand grip) with a score
Time frame: at inclusion
strenght - physical condition
physical condition will be asessed by grip strength (hand grip) with a score
Time frame: at 3 months after inclusion
strenght - physical condition
physical condition will be asessed by grip strength (hand grip) with a score
Time frame: at 6 months after inclusion
evaluation of quality of life
quality of life will be assessed by SF 12 a short version of the MEDICAL OUTCOME STUDY SHORT FORME GENERAL HEALTH SURVEY (score)
Time frame: at inclusion
evaluation of quality of life
quality of life will be assessed by SF 12 a short version of the MEDICAL OUTCOME STUDY SHORT FORME GENERAL HEALTH SURVEY (score)
Time frame: at 3 months after inclusion
evaluation of quality of life
quality of life will be assessed by SF 12 a short version of the MEDICAL OUTCOME STUDY SHORT FORME GENERAL HEALTH SURVEY (score)
Time frame: at 6 months after inclusion
anxiety and depression
anxiety and depression will be assessed by the HADS " Hospital Anxiety and Depression Scale " and giving a score
Time frame: at inclusion
anxiety and depression
anxiety and depression will be assessed by the HADS " Hospital Anxiety and Depression Scale " and giving a score
Time frame: at 3 months after inclusion
anxiety and depression
anxiety and depression will be assessed by the HADS " Hospital Anxiety and Depression Scale " and giving a score
Time frame: at 6 months after inclusion
apathy
apathy will be assessed by the apathy inventory questionnary and givig a score
Time frame: at inclusion
apathy
apathy will be assessed by the apathy inventory questionnary and givig a score
Time frame: at 3 months after inclusion
apathy
apathy will be assessed by the apathy inventory questionnary and givig a score
Time frame: at 6 months after inclusion
This study is completed, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.
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Centre Hospitalier Universitaire de Nice