An observational study in Optical Coherence Tomography, Refractive Errors and Myopia, sponsored by University of Nebraska. Recruiting at 1 site in United States. Open to participants aged 19 Years and older. Per ClinicalTrials.gov, last updated 2026-08-26.
Sponsored by University of Nebraska · Observational
Corrective eye surgeries, such as Lasik, are widely used to correct focusing problems such as myopia, or nearsightedness. Often these patients develop other conditions like myopic maculopathy or glaucoma which require monitoring with optical coherence tomography (OCT). Since OCT is a light-based test and changes the refractive status of the eye (in the cornea or the lens), it can potentially affect the results of the OCT measurements but has not been sufficiently studied. This pilot study aims at studying the potential change in OCT parameters in the eye after undergoing such surgery.
Refractive surgeries are widely used in patients with ametropia. Refractive surgery is most commonly performed in patients with myopia. These patients often have a predilection for developing other conditions in the posterior segment of the eye, like myopic maculopathy or glaucoma which require monitoring with optical coherence tomography (OCT). Since OCT is a light-based test and changes in the refractive status of the eye (in the cornea or the lens) can potentially affect the results of the OCT measurements. Literature review reveals that the effect of significant changes in refractive power of the eye on the parameters of optical coherence tomography (OCT) has not been sufficiently studied. Some authors simulated the effect of refractive surgery using a contact lens but had diverging results. This prospective pilot study aims at studying the potential change in OCT parameters in the eye after undergoing refractive surgery.
1,159 studies on the registry are indexed under Myopia; 225 are open to participants now.
This study's planned enrollment of 33 is below the median of 150 across 204 observational studies indexed under Myopia.
Browse Myopia studies →University of Nebraska is the lead sponsor of 496 studies on the registry; 67 are open to participants now.
Of its 83 completed or terminated interventional studies of FDA-regulated products, 53 (64%) have results posted.
Compared within Myopia, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Refractive Errors. The counts are of registry records indexed under each term, refreshed daily. How we classify →
All subjects in the study will be adults aged 19 years or more, that fits the typical age profile of patients in the refractive surgery clinic. Refractive surgery is an elective surgery and the patients are encouraged to ask questions about the study. This is an observational study and all aspects of care, including procedures, visits, and exams, carried out as part of the study represent standard of care. Patients visiting the refractive surgery clinic will be given an option to participate in the study if they meet the selection criteria. The clinical care of the patient will not be affected by the patient's participation or non-participation in the study.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Patients aged 19 years or more who are scheduled to undergo refractive surgery will be included in the study. OCT will be performed at baseline (before surgery), 1 day after surgery and 1 week after surgery. Each patient will be tested 3 times.
Diagnostic Test: Optical coherence tomography
Posterior segment OCT (a non-contact procedure performed over one minute) is additionally performed for patients participating in this study. Proportion of change in measurements in microns will be analyzed.
Macular thickness
Proportion of Change in thickness of retina and its layers measured in microns
Time frame: 1 day after refractive procedure
Macular thickness
Proportion of Change in thickness of retina and its layers measured in microns
Time frame: 1 week after refractive procedure
Choroidal thickness
Proportion of Change in thickness of choroid and its layers measured in microns
Time frame: 1 day after refractive procedure
Choroidal thickness
Proportion of Change in thickness of choroid and its layers measured in microns
Time frame: 1 week after refractive procedure
visual acuity
Proportion of Change in clarity of vision, measured in logarithm of Minimal Angle of Resolution (logMAR) units
Time frame: 1 day after refractive procedure
visual acuity
Proportion of Change in clarity of vision, measured in logarithm of Minimal Angle of Resolution (logMAR) units
Time frame: 1 week after refractive procedure
central corneal thickness
Proportion of Change in thickness of cornea measured in microns
Time frame: 1 day after refractive procedure
central corneal thickness
Proportion of Change in thickness of cornea measured in microns
Time frame: 1 week after refractive procedure
anterior chamber depth
Proportion of Change in depth of anterior chamber of the eye measured in microns
Time frame: 1 day after refractive procedure
anterior chamber depth
Proportion of Change in depth of anterior chamber of the eye measured in microns
Time frame: 1 week after refractive procedure
keratometry
Proportion of Change in corneal curvature measured in diopters
Time frame: 1 day after refractive procedure
keratometry
Proportion of Change in corneal curvature measured in diopters
Time frame: 1 week after refractive procedure
Plan to share: No
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