An interventional study of Threshold inspiratory muscle trainer device and Adjusting mechanical ventilator trigger sensitivity in Respiratory Failure, sponsored by Cairo University. Completed at 1 site in Egypt. Open to participants aged 50 Years to 70 Years. Per ClinicalTrials.gov, last updated 2023-05-06.
Sponsored by Cairo University · Not applicable, Interventional, and Supportive care
Ninety adult patients from both gender, with acute respiratory failure, intubated and mechanically ventilated. Their ages ranged from 50 to 70 years. They were selected from Intensive Care Unit (ICU), Department of Chest Diseases, Cairo University Hospitals. They have randomly assigned into three equal groups. Group (A): trained by threshold IMT device plus routine physical therapy. Group (B): trained by adjusting MV trigger sensitivity plus routine physical therapy. Group (C): only received routine physical therapy. (Negative inspiratory force NIF, arterial blood gases, P/F ration, respiratory rate RR, tidal volume VT, and rapid shallow breathing index RSBI) were measured before the study and at the end of the study (just before weaning for successfully weaned patients, or on the 10 day of intervention for failed weaning patients).
1,650 studies on the registry are indexed under Respiratory Insufficiency; 296 are open to participants now.
This study's enrollment of 90 is above the median of 55 across 1,043 interventional studies indexed under Respiratory Insufficiency.
Browse Respiratory Insufficiency studies →Cairo University is the lead sponsor of 4,780 studies on the registry; 1,427 are open to participants now.
Of its 36 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Training by inspiratory muscle device plus chest physiotherapy
Other: Threshold inspiratory muscle trainer device · Other: Chest physiotherapy
Adjusting trigger sensitivity of the mechanical ventilator to the lowest pressure tolerated plus chest physiotherapy
Other: Adjusting mechanical ventilator trigger sensitivity · Other: Chest physiotherapy
Routine chest physiotherapy
Other: Chest physiotherapy
The threshold inspiratory muscle trainer (IMT) device offers resistance to respiration through the spring-loaded valve.
modifying the mechanical ventilator trigger sensitivity so that patients can only initiate inspiratory flow by producing more negative intrathoracic pressure
Conventional chest physiotherapy
partial pressure of oxygen(PaO2)
arterial blood sample was taken and examined thePao2
Time frame: change from baseline at one week
partial pressure of carbon dioxide(PaCO2)
arterial blood sample was taken and examined the PaCO2
Time frame: change from baseline at one week
Respiratory rate (RR)
Number of respiratory cycles per minute
Time frame: change from baseline at one week
tidal volume (TV)
volume of air inspired in quiet breathing
Time frame: change from baseline at one week
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Apr 2023. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Cairo University