An observational study in Myopia, sponsored by Singapore Eye Research Institute. Completed at 1 site in Singapore. Open to participants aged 10 Years to 99 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-04-12.
Sponsored by Singapore Eye Research Institute · Observational
The purpose of the study is to use the polarization sensitive optical coherence tomography (PS-OCT) developed by Singapore Eye Research Institute, to evaluate the potential OCT scleral biomarkers capable of predicting risk of myopia progression.
984 studies on the registry are indexed under Myopia; 210 are open to participants now.
This study's enrollment of 178 is above the median of 150 across 173 observational studies indexed under Myopia.
Browse Myopia studies →Singapore Eye Research Institute is the lead sponsor of 26 studies on the registry; 12 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Adult and children cohorts
(Adult Cohort)
(Children Cohort)
Exclusion Criteria:
(Adult Cohort)
* Aged 21 and above * Ability to provide informed consent * 42 normal controls: No diabetes and free from clinically relevant eye disease that interferes with the aim of the study i.e. glaucoma, diabetic retinopathy, age-related macular degeneration, uveitis, or vascular occlusive diseases * 76 subjects with pathological myopia (up to -12 dioptres) or staphyloma
Device: Polarization sensitive optical coherence tomography (PS-OCT)
* Aged 10 to 18 * 23 subjects with low to moderate myopia (-0.75 to -6 dioptres) * 23 subjects with high myopia (more than -6 dioptres) * Ability of legal representative and subject to provide informed consent
Device: Polarization sensitive optical coherence tomography (PS-OCT)
The PS-OCT is a prototype, also known as an early version of a medical device, specially developed by the Ocular Imaging Research Group, Singapore Eye Research Institute, for prediction of myopia progression. It has not been approved for use in any other country. There is currently no method to identify who is at risk of myopia progression. The PS-OCT device will provide the capabilities of OCT scleral biomarkers, which may have the potential to identify individuals at high risk for myopia.
Primary Aim
High reproducibility in myopia cases as shown in PS-OCT derived sclera anisotropy patterns
Time frame: 1.5 years
Secondary Aim
Changes in scleral anisotropy in adults with different degrees of myopia (up to -12 dioptres), as associated with the presence of staphyloma
Time frame: 1.5 years
Tertiary Aim
Anisotropy correlation with refraction and axial length in children with low (-0.75 to -6 dioptres) and high (more than -6 dioptres) myopia, as measured by PS-OCT
Time frame: 1.5 years
This study is completed, as verified in Apr 2023. You cannot join it, but the record below documents what was studied.
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Singapore Eye Research Institute