A Phase 2 interventional study of Ischemic Conditioning in Aging, Fragility and Endothelial Dysfunction, sponsored by Medical College of Wisconsin. Recruiting at 1 site in United States. Open to participants aged 65 Years to 85 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-09-23.
Sponsored by Medical College of Wisconsin · Phase 2, Interventional, and Treatment
Among 148 studies in Aneurysm with a site in United States — 31 open to participants now, 38 under way, none of them phase 3. Aneurysm · United States.
Among the 148 studies in Aneurysm with a site in United States, this one is the 56th largest by planned enrollment of the 111 interventional ones that give a count, is one of 3 that started in 2023, is one of 9 in phase 2, reaches primary completion later than 25 of the 37 other live ones, and was the 132nd registered.
381 studies on the registry are indexed under Aneurysm; 78 are open to participants now.
Browse Aneurysm studies →31 of the 148 studies in Aneurysm with a site in United States are open now. Recruiting first, the newest first:
phenox Inc. · Sites in United States
Ages 18+
Vascutek Ltd. · Sites in United States, Austria, Germany and 2 more countries
Ages 18+
Craig Hospital · Sites in United States
Ages 18–89 · Men only
Stryker Neurovascular · Sites in United States
Ages 18–80
Cerus Endovascular, Inc. · Sites in United States
Ages 18–75
A study can be open while its sites in United States have not opened yet or have stopped. Only those recruiting at a site in United States →
Of the 67 Aneurysm studies recruiting now, 42 (63%) set no upper age limit and 7 (10%) stop at 75 or younger; 6 take children under 18; 9 take healthy volunteers.
This study: 65 Years to 85 Years · all sexes · healthy volunteers too.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
148 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 27 · Phase 2 12 · Phase 3 1 · Phase 4 8
First in 1997; this study’s year is marked. 3 started in 2023.
By drug class, each counting the studies that test any of its medicines:
This study's planned enrollment of 60 is above the median of 46 across 235 interventional studies indexed under Aneurysm.
Median enrollment 60 across the 111 interventional studies, 114 across the 33 observational. Of the 91 that completed or were terminated, 35 (38%) have results posted.
This tab as a report to print or save as PDF → With an account.
46 of 148 have an industry lead sponsor. The 10 most frequent:
Medical College of Wisconsin is the lead sponsor of 548 studies on the registry; 122 are open to participants now.
Of its 75 completed or terminated interventional studies of FDA-regulated products, 57 (76%) have results posted.
Medical College of Wisconsin has 2 studies filed under Aneurysm — fewer than ten, so there is no comparison to draw.
11 of the studies in Aneurysm with a site in United States that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07116408Wright State UniversityIntranasal Sphenopalatine Ganglion Blockade for Headaches Following Aneurysmal Subarachnoid Hemorrhage | 2026-11 |
| NCT06290713University of FloridaVasodilator and Exercise Study for DMD (VASO-REx) | 2026-11 |
| NCT06417177University of Missouri-ColumbiaImpact of Early Aging and Menopause on the Vascular Responses to Hypoxia | 2026-12 |
| NCT05522075The University of Texas at ArlingtonReducing Blood Pressure in Mid-life Adult Binge Drinkers | 2026-12-31 |
| NCT06793059Jacobs instituteEvaluation of Flow Diverter Technology Device for Intracranial Aneurysm (SHIELD) | 2027-01-01 |
Among the 148 studies in Aneurysm with a site in United States, from their registry updates:
This tab as a report to print or save as PDF → With an account.
The goal of this clinical trial is to see how small blood vessels respond to the stress of high intensity exercise, and if a safe and simple intervention called ischemic conditioning can protect blood vessels from the stress of exercise.
Participants will come in for 3 study visits and get home-based ischemic conditioning. At Study Visit 1, participants will be assessed for their frailty and physical function. Afterwards, they will perform an exercise test. At Study Visit 2, patients will undergo 2 microvascular assessments, perform a high-intensity exercise, then undergo the same 2 microvascular assessments again. Participants will be given a handheld sphygmomanometer and a blood pressure cuff to take home. Depending on which group the participants get randomized into, participants will place the blood pressure cuff around their non-dominant upper arm and inflate to either a low or high pressure for 2 weeks at home. Participants will repeat the same steps in Study Visit 2 for Study Visit 3. In addition, participants will also be assessed for their frailty and physical function.
In elderly individuals the small blood vessels that regulate blood flow to organs and other tissues can become damaged when they are exposed to stress, which can lead to complications following stressful events like surgery. In this study we will examine how these blood vessels respond to the stress of high intensity exercise, and if a safe and simple intervention called ischemic conditioning can increase resiliency of these vessels.
Our previous work showed that conditioned athletes are protected from the stress of a single, high intensity exercise bout whereas non-athletes are not. Others have shown that elderly individuals have reduced large artery function following the high intensity exercise. This study will be the first to examine how the small blood vessels respond to this stress in the elderly. Participants will be asked to come in for 3 study visits.
Study Visit 1
Study Visit 2
Home-based Ischemic Conditioning
Visit 3
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
We will use a randomized block design to randomize individuals into either Ischemic Conditioning-Low or Ischemic Conditioning-High group using an online randomizer. A handheld sphygmomanometer and blood pressure cuff will be given to study participants. For the Ischemic Conditioning-Low group participants, while sitting, the cuff will be placed around the non-dominant upper arm and inflated to 10 mmHg for 5 min, then released for a 5-min recovery period. A 5-min inflation period is most used. Five cycles of inflation/recovery will be performed. All participants will perform the intervention daily for 2 weeks. Participants will complete daily log sheets documenting the time and pressure of each cuff inflation.
Other: Ischemic Conditioning
We will use a randomized block design to randomize individuals into either Ischemic Conditioning-Low or Ischemic Conditioning-High group using an online randomizer. A handheld sphygmomanometer and blood pressure cuff will be given to study participants. For the Ischemic Conditioning-High group participants, while sitting, the cuff will be placed around the non-dominant upper arm and inflated to 225 mmHg for 5 min, then released for a 5-min recovery period. A 5-min inflation period is most used. Five cycles of inflation/recovery will be performed. All participants will perform the intervention daily for 2 weeks. Participants will complete daily log sheets documenting the time and pressure of each cuff inflation.
Other: Ischemic Conditioning
We will use a randomized block design to randomize individuals into either Ischemic Conditioning-Low or Ischemic Conditioning-High group using an online randomizer. A handheld sphygmomanometer and blood pressure cuff will be given to study participants. For the Ischemic Conditioning-High group participants, while sitting, the cuff will be placed around the non-dominant upper arm and inflated to 225 mmHg for 5 min, then released for a 5-min recovery period. A 5-min inflation period is most used. Five cycles of inflation/recovery will be performed. For the Ischemic Conditioning-Low group participants, the cuff will be inflated to 10 mmHg instead. All participants will perform the intervention daily for 2 weeks. Participants will complete daily log sheets documenting the time and pressure of each cuff inflation.
Change in Acetylcholine-mediated dilation
Cutaneous vascular conductance in response to acetylcholine infusion will be calculated as laser Doppler flux / mean arterial pressure
Time frame: 2 hours
Change in Perfused Vessel Density
Total vessel density (TVD) will be calculated using the DeBacker Score manual analysis on all images that have a minimum microcirculation image quality score (MIQS) of 10. Perfused vessel density (PVD) will be calculated by multiplying total vessel density (TVD) x proportion of perfused vessels (PPV%).
Time frame: 0.5 hours
Plan to share: No — There are no current plans to share individual participant data with other researchers.
No publications or documents are linked to this record.
Started May 2023 (actual). Primary completion is estimated for Dec 2028, 67 months after the start.
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Medical College of Wisconsin →