An interventional study of Resistance training in Sarcopenia, Functional Decline and Muscle Architecture, sponsored by Odense University Hospital. Completed at 1 site in Denmark. Open to participants aged 65 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-03-27.
Sponsored by Odense University Hospital · Not applicable, Interventional, and Treatment
Sarcopenia characterised by loss of muscle mass, muscle strength and physical performance burdens many older adults since the condition is related to functional decline. Periods of inactivity such as during hospitalisation leads to further functional decline. It has been reported that the loss of muscle mass associated with sarcopenia not only entails a decrease in muscle mass but also changes in muscle architecture. Knowledge on changes in muscle architecture is essential since it is one of the most important determinants on muscle strength and thus physical performance. The main objective of this study is to investigate changes in muscle architecture and physical performance during acute hospitalisation and after discharge in older adults and subsequently the effectiveness of resistance training of the lower limb during acute hospitalisation. If successful, our study could have a great impact on the individual, as well as societal level, due to a better understanding of the factors related to sarcopenia and the prevention of functional decline as a result of hospitalisation.
1,208 studies on the registry are indexed under Sarcopenia; 402 are open to participants now.
This study's enrollment of 274 is above the median of 60 across 775 interventional studies indexed under Sarcopenia.
Browse Sarcopenia studies →Odense University Hospital is the lead sponsor of 468 studies on the registry; 109 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Group of participants receiving resistance training during hospitalisation
Other: Resistance training
Group of participants receiving sham training during hospitalisation
Other: Resistance training
Moderate resistance training by a innovative training robot 2 times a day during hospitalisation
Change from baseline B-mode ultrasonography
Muscle architecture of the m Vastus Lateralis assessed with B-mode ultrasonography.
Time frame: Baseline (day of hospitalisation) to day of discharge from hospital (an average of a week).
Change from baseline 4 meter Gait Speed Test
Physical performance evaluated by the 4m Gait Speed test
Time frame: Baseline (Day of hospitalisation) to day of discharge from hospital (an average of a week).
Change from baseline B-mode ultrasonography
Muscle architecture of the muscle vastus lateralis assessed with B-mode ultrasonography.
Time frame: Change from baseline (day of hospitalisation) to 1-month follow-up and 3-months follow-up
Change from baseline 4 meter Gait Speed Test
Physical performance evaluated by the 4m Gait Speed test
Time frame: Change from baseline (day of hospitalisation) to 1-month follow-up and 3-months follow-up
Change from baseline 30s Chair Stand test
Maximal muscle strength of the lower extremities evaluated by the 30s Chair Stand Test or the m30s Chair Stand Test (Modified).
Time frame: Baseline (day of hospitalisation) to day of discharge from hospital (an average of a week)
Change from baseline Barthel-Index 100 (Shahs version)
Functional level evaluated by The Barthel-Index 100 (Shahs version)
Time frame: Baseline (day of hospitalisation) to day of discharge from hospital (an average of a week)
Change from baseline Bioimpedance
Muscle quantity (kg) on wholebody level evaluated by Bioimpedance
Time frame: Baseline (day of hospitalisation) to day of discharge from hospital (an average of a week)
Length of hospital stay
Number of days hospitalised
Time frame: Baseline (day of hospitalisation) to day of discharge from hospital (an average of a week)
Mortality
Administrative registers will be used to assess mortality
Time frame: Baseline (day of hospitalization) to 3-months follow-up
Unplanned hospitalisation
Patients will be followed through a review of medical records for any unplanned Adminstrative registers will be used to assess any unplanned hospitalisation during the period of inclusion.
Time frame: Day of discharge from hospital to 3-months follow-up
Individual level of physiotherapy
Adminstrative registers and municipalities health records will be used to assess the individual level of physiotherapy (minutes of consultation) in the period of inclusion.
Time frame: Baseline (day of hospitalisation) to 3-months follow-up
Plan to share: No — No plan
No publications or documents are linked to this record.
This study is completed, as verified in Mar 2025. You cannot join it, but the record below documents what was studied.
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Odense University Hospital