An interventional study of Oxycodone and Pregabalin and Oxycodone and placebo capsules in Chronic Post Operative Pain, Oxycodone and Pregabalin, sponsored by Beijing Tiantan Hospital. Status unknown at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-08-01.
Sponsored by Beijing Tiantan Hospital · Not applicable, Interventional, and Treatment
Chronic postoperative pain is one of the common perioperative complications, which seriously affects the prognosis of patients. Currently, no specific perioperative pain management strategy has been found to be effective in preventing and treating chronic postoperative pain in patients undergoing spinal surgery. At present, oxycodone has been widely recognized in different surgical populations for the control of acute postoperative pain, but its contribution to chronic postoperative pain remains unknown. Meanwhile, whether pregabalin can reduce the occurrence of chronic postoperative pain remains controversial, and whether the combination of the two drugs can control the occurrence of chronic postoperative pain in a more comprehensive way remains unknown. Therefore, we intend to conduct this randomized-controlled, factorial design study to determine the efficacy and safety of oxycodone combined with pregabalin in the treatment of chronic postoperative pain in patients undergoing spinal surgery.
5,224 studies on the registry are indexed under Pain, Postoperative; 1,154 are open to participants now.
This study's planned enrollment of 264 is above the median of 75 across 4,457 interventional studies indexed under Pain, Postoperative.
Browse Pain, Postoperative studies →Beijing Tiantan Hospital is the lead sponsor of 481 studies on the registry; 287 are open to participants now.
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Oxycodone+Pregabalin
Drug: Oxycodone and Pregabalin
Oxycodone+placebo capsules
Drug: Oxycodone and placebo capsules
NS+Pregabalin
Drug: Pregabalin and NS
NS+placebo capsules
Drug: placebo capsules and NS
Drug pages: Oxycodone · Pregabalin
Oxycodone: 150mg PCIA during 3 days postoperatively Pregabalin: 150mg preoperatvely, 75mg BID for POD1\~7,75mg QD for POD8\~14
Oxycodone: 150mg PCIA for 3 days postoperatively placebo capsules: same numbers as pregabalin at each time point
Pregabalin: 150mg preoperatively, 75mg BID for POD1\~7,75mg QD for POD8\~14 NS: Equal volume NS for 3 days postoperatively
placebo capsules: same numbers as pregabalin at each time point NS: Equal volume NS for 3 days postoperatively
the incidence of CPSP
The incidence of chronic postsurgical pain, the CPSP was defined as an NRS score \>3 (0\~10).
Time frame: 3 months after surgery
This study is status unknown, as verified in Jul 2024. You cannot join it, but the record below documents what was studied.
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Studies of the drugs tested here: Oxycodone · Pregabalin