An interventional study of L-tyrosine supplementation and Placebo supplementation in Stress, sponsored by Centre Hospitalier Universitaire de Nice. Completed at 1 site in Monaco. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2026-11-03.
Sponsored by Centre Hospitalier Universitaire de Nice · Not applicable, Interventional, and Prevention
Patient undergoing surgery is exposed to many stressors: diachronic (gesture anticipation), synchronic (intraoperative aggression) and historical (subject's personality). Reducing the level of stress experienced is a factor for improving the quality of the surgical gesture and the simplicity of the follow-up. The previous methods used were intended to reduce the body's reactivity to aggressions through anaesthesia consultation and L-Tyrosine supplementation. Currently with the progression of outpatient surgery and the need for early rehabilitation, L-Tyrosine supplementation is suppressed to improve recovery. Some patients, however, have a high level of stress that may require anxiolysis when the ideal treatment does not exist (ineffective hydroxyzine, benzodiazepines having many side effects). The strategy of this work is to improve the body's ability to respond to stressors, by administering l-tyrosine with no impact on waking or returning home.
Centre Hospitalier Universitaire de Nice is the lead sponsor of 723 studies on the registry; 176 are open to participants now.
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Exclusion Criteria:
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The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
ASA physical status
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Dietary Supplement: L-tyrosine supplementation
Dietary Supplement: Placebo supplementation
L-Tyrosine supplementation before surgery for inguinal hernia under general anaesthesia
Placebo supplementation before surgery for inguinal hernia under general anaesthesia
Variation of anxiety status
Anxiety score measured using Y-A STAI
Time frame: between the day before surgery and thes day after surgery
Other stress markers variation
anxiety visual analogue scale (from 0 to 10, 10 is worst)
Time frame: the day before surgery
Other stress markers variation
anxiety visual analogue scale (from 0 to 10, 10 is worst)
Time frame: the day after surgery
Other stress markers variation
heart blood pressure (Systolic and diastolic)
Time frame: the day before surgery
Other stress markers variation
heart blood pressure (Systolic and diastolic)
Time frame: the day after surgery
Other stress markers variation
cortisol dosage
Time frame: the day before surgery
Other stress markers variation
cortisol dosage
Time frame: the day after surgery
Plan to share: No — Not scheduled
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Nov 2026. You cannot join it, but the record below documents what was studied.
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