An interventional study of L-tyrosine supplementation and Placebo supplementation in Stress, sponsored by Centre Hospitalier Universitaire de Nice. Recruiting at 1 site in Monaco. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2025-12-08.
Sponsored by Centre Hospitalier Universitaire de Nice · Not applicable, Interventional, and Prevention
Patient undergoing surgery is exposed to many stressors: diachronic (gesture anticipation), synchronic (intraoperative aggression) and historical (subject's personality). Reducing the level of stress experienced is a factor for improving the quality of the surgical gesture and the simplicity of the follow-up. The previous methods used were intended to reduce the body's reactivity to aggressions through anaesthesia consultation and L-Tyrosine supplementation. Currently with the progression of outpatient surgery and the need for early rehabilitation, L-Tyrosine supplementation is suppressed to improve recovery. Some patients, however, have a high level of stress that may require anxiolysis when the ideal treatment does not exist (ineffective hydroxyzine, benzodiazepines having many side effects). The strategy of this work is to improve the body's ability to respond to stressors, by administering l-tyrosine with no impact on waking or returning home.
Exclusion Criteria:
Dietary Supplement: L-tyrosine supplementation
Dietary Supplement: Placebo supplementation
L-Tyrosine supplementation before surgery for inguinal hernia under general anaesthesia
Placebo supplementation before surgery for inguinal hernia under general anaesthesia
Variation of anxiety status
Anxiety score measured using Y-A STAI
Time frame: between the day before surgery and thes day after surgery
Other stress markers variation
anxiety visual analogue scale (from 0 to 10, 10 is worst)
Time frame: the day before surgery
Other stress markers variation
anxiety visual analogue scale (from 0 to 10, 10 is worst)
Time frame: the day after surgery
Other stress markers variation
heart blood pressure (Systolic and diastolic)
Time frame: the day before surgery
Other stress markers variation
heart blood pressure (Systolic and diastolic)
Time frame: the day after surgery
Other stress markers variation
cortisol dosage
Time frame: the day before surgery
Other stress markers variation
cortisol dosage
Time frame: the day after surgery
Plan to share: No — Not scheduled
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Centre Hospitalier Universitaire de Nice