An interventional study of Upper-limb training involving RAS and Upper-limb training without the aid of RAS in Acoustic Stimulation, Parkinson Disease and Electroencephalography, sponsored by The Hong Kong Polytechnic University. Not yet recruiting. Open to participants aged 18 Years to 85 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-03-23.
Sponsored by The Hong Kong Polytechnic University · Not applicable, Interventional, and Treatment
Introduction Bradykinesia (i.e., slow movements) is one of the most prominent symptoms of Parkinson's disease (PD) and has a negative impact on quality of life. Rhythmic auditory stimulation (RAS), a widely used and promising treatment technique, has been shown to effectively improve gait speed in PD patients. However, only few studies have explored effects and neural mechanisms of RAS on upper-limb movements. We will conduct two studies to investigate effects and mechanisms of RAS on upper-limb movements in PD patients. The purpose of this study is to examine effects and neural mechanisms of upper-limb movement training involving RAS in PD patients.
Methods This study will recruit patients with PD and healthy controls. This study will randomly assign PD patients into two groups: the PD-RAS group and the PD-noRAS group, and healthy controls into the HC-RAS group and the HC-noRAS group. A 7-day upper-limb training involving RAS (for the PD-RAS group and the HC-RAS group) or without RAS (for the PD-noRAS group and the HC-noRAS group) will be provided. EEG and behavioral assessments will be conducted before and after the first day of training, and after the seven-day training program. Two-way repeated measures analysis of variance will be performed to investigate the group and time effects on upper-limb function and neural activity.
Study significance The training program will serve as a reference for clinical practitioners who are interested in using RAS in clinical training for PD patients.
4,487 studies on the registry are indexed under Parkinson Disease; 1,082 are open to participants now.
This study's planned enrollment of 72 is above the median of 40 across 3,294 interventional studies indexed under Parkinson Disease.
Browse Parkinson Disease studies →The Hong Kong Polytechnic University is the lead sponsor of 659 studies on the registry; 250 are open to participants now.
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Exclusion Criteria:
training involving RAS
Behavioral: Upper-limb training involving RAS
training without the aid of RAS
Behavioral: Upper-limb training without the aid of RAS
training involving RAS
Behavioral: Upper-limb training involving RAS
training without the aid of RAS
Behavioral: Upper-limb training without the aid of RAS
Three target bowls, labeled as the left, middle, and right target bowl, will be placed on the table at an equal distance from the main bowl. The distance between a target bowl and the main bowl is set at 30 cm. Wooden beads with a diameter of 2 cm will be put in target bowls. The main bowl will be placed in front of the patient. Patients will be asked to listen to the RAS sound, use the right hand to take one bead at a time from the left target bowl to the main bowl, repeat this movement for the middle and right target bowls, and keep repeating this order. They should keep their movements consistent with the sound of the RAS, with one RAS sound corresponding to one pick-up movement. Each daily training will consist of three rounds separated by two 5-minute breaks. Each round will consist of four consecutive sessions (for each session: 2-minute training followed by a 30-second break). The training will last for a total of 7 days.
Three target bowls, labeled as the left, middle, and right target bowl, will be placed on the table at an equal distance from the main bowl. The distance between a target bowl and the main bowl is set at 30 cm. Wooden beads with a diameter of 2 cm will be put in target bowls. The main bowl will be placed in front of the patient. Patients will be asked to use the right hand to take one bead at a time from the left target bowl to the main bowl, repeat this movement for the middle and right target bowls, and keep repeating this order. They are asked to execute the task as fast as possible. Each daily training will consist of three rounds separated by two 5-minute breaks. Each round will consist of four consecutive sessions (for each session: 2-minute training followed by a 30-second break). The training will last for a total of 7 days.
Electroencephalography (EEG)
The power (unit:Watt) of EEG will be calculated.
Time frame: Assessments will be performed before the first day of training.
Electroencephalography (EEG)
The power (unit:Watt) of EEG will be calculated.
Time frame: Assessments will be performed after the first day of training.
Electroencephalography (EEG)
The power (unit:Watt) of EEG will be calculated.
Time frame: Assessments will be performed after the seven-day training program.
Electroencephalography (EEG)
The functional connectivity (unit:coherence) of EEG will be calculated.
Time frame: Assessments will be performed before the first day of training.
Electroencephalography (EEG)
The functional connectivity (unit:coherence) of EEG will be calculated.
Time frame: Assessments will be performed after the first day of training.
Electroencephalography (EEG)
The functional connectivity (unit:coherence) of EEG will be calculated.
Time frame: Assessments will be performed after the seven-day training program.
The box and block test (BBT)
The BBT is used to measure gross manual dexterity as well as upper-limb movement speed.
Time frame: Assessments will be performed before the first day of training.
The box and block test (BBT)
The BBT is used to measure gross manual dexterity as well as upper-limb movement speed.
Time frame: Assessments will be performed after the first day of training.
The box and block test (BBT)
The BBT is used to measure gross manual dexterity as well as upper-limb movement speed.
Time frame: Assessments will be performed after the seven-day training program.
The nine hole peg test (NHPT)
The NHPT is a widely used measure of hand dexterity in a broad range of ages and populations.
Time frame: Assessments will be performed before the first day of training.
The nine hole peg test (NHPT)
The NHPT is a widely used measure of hand dexterity in a broad range of ages and populations.
Time frame: Assessments will be performed after the first day of training.
The nine hole peg test (NHPT)
The NHPT is a widely used measure of hand dexterity in a broad range of ages and populations.
Time frame: Assessments will be performed after the seven-day training program.
No study locations are listed for this record.
Plan to share: No
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The Hong Kong Polytechnic University