An interventional study of Saline and Norepinephrine in Norepinephrine, Glypressin, Tourniquet Deflation and Hypotension, sponsored by Tanta University. Completed at 1 site in Egypt. Open to participants aged 40 Years to 65 Years. Per ClinicalTrials.gov, last updated 2023-11-22.
Sponsored by Tanta University · Not applicable, Interventional, and Prevention
Pneumatic tourniquet is usually used in orthopedic surgeries, as it helps to decrease operative bed bleeding, and thus, maintaining a clean and dry surgical field allowing easy and clear identification of the anatomical structures. Despite that advantage, after its deflation, there is a blood volume shift towards that ischemic area, which may decrease cardiac preload leading to hypotension
Hemodynamic changes after tourniquet deflation include; hypotension, tachycardia and increase in cardiac index. These changes may be insignificant for healthy individuals but, risky for patients with compromised cardiovascular system and geriatric population.
Hypovolemia is a common problem in many clinical situations. The mortality of hypovolemic shock is directly related to the severity and duration of organ hypoperfusion.
Management of hypotension include frequent monitoring of blood pressure, fluid therapy, non-pharmacological methods, and vasopressors. Fluid therapy by crystalloids or colloids has been the traditional approach to restore volume and can be given as preload or co-load .Non pharmacological methods include positioning and leg compression. Trendelenburg position can increase venous return to the heart. Leg compression by flexion of the hip, elastic bandages, or stockings. An efficient method to treat spinal hypotension is administration of vasopressors, either given by infusion or boluses. Vasopressor drugs act by reversing the circulatory effect of sympathetic blockade. They also restore vascular tone and preserve venous return and cardiac filling
1,003 studies on the registry are indexed under Hypotension; 173 are open to participants now.
This study's enrollment of 135 is above the median of 80 across 675 interventional studies indexed under Hypotension.
Browse Hypotension studies →Tanta University is the lead sponsor of 963 studies on the registry; 304 are open to participants now.
Of its 16 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria
Drug: Saline
Drug: Norepinephrine
Drug: glypressin
patient received normal saline 4ml/kg/hr with deflation of tourniquet
Also known as: control
patient received noradrenaline infusion at rate 0.1 mcg/kg/min. with deflation of tourniquet
Also known as: noradrenaline
patient receive glypressin infusion at rate 2 mcg/kg/hr.
Also known as: vasopressin
change of mean arterial blood pressure
change of mean arterial bllod pressure till 30 min after deflation of the tourniquet.
Time frame: 30 minutes after tourniquet deflation
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Nov 2023. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Tanta University