An observational study in Parkinson Disease Dementia and Parkinson Disease, sponsored by Assiut University. Status unknown at 1 site in Egypt. Open to participants aged 50 Years to 80 Years. Per ClinicalTrials.gov, last updated 2023-03-08.
Sponsored by Assiut University · Observational
To compare between Idiopathic PD versus Parkinson-Dementia complex using different modalities: Demographic, Clinical, genetic, Psychometric and electrophysiologically
Parkinson's disease (PD), is one of the commonest neurodegenerative disorders with a severe progressive course and major impact on patients' quality of life. The development of late-onset PD likely results from the interaction of genetic and environmental factors in the context of brain aging.
Although several environmental exposures have been implicated, evidence for their causal contributions is limited.
PD in Egypt is a rapidly emerging concern as prevalence rose by 40.7% between 1990 and 2016, one of the highest increases in the world. which influences us to dig further in the genetic basis behind the scenes leading to that leap.
Cognitive impairment in PD constitutes a major source of disease burden for patients and families, and has a significant negative effect on patients' quality of life. Cognitive impairment without dementia is designated as mild cognitive impairment of PD (PD-MCI), where the activities of daily living are grossly preserved, whereas dementia associated with PD is designated as PD-D.
Parkinson's disease dementia is a neurofibrillary tangle degeneration involving the deposition of Alzheimer-type tau, predominantly in the mesial temporal cortex, brainstem, and basal ganglia.
The prevalence of Parkinson's Disease Dementia (PD-D) in the general population aged 65 years and over was 0.3 to 0.5%, and 3 to 4% of patients with dementia in the general population were estimated to be due to PD-D.
Transcranial magnetic stimulation (TMS) is a noninvasive neurophysiological technique for assessing human motor cortical function. With TMS, the underlying motor cortex is stimulated by an electric current induced by a transient magnetic field, generated in response to the passage of a large current through the stimulating coil located on the patient's scalp.
4,487 studies on the registry are indexed under Parkinson Disease; 1,081 are open to participants now.
This study's planned enrollment of 40 is below the median of 96 across 1,056 observational studies indexed under Parkinson Disease.
Browse Parkinson Disease studies →Assiut University is the lead sponsor of 4,901 studies on the registry; 2,098 are open to participants now.
Of its 13 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Counted across the registry records on this site, refreshed daily.
patients with parkinson's disease and parkinson dementia complex
Exclusion Criteria:
Genetic analysis, clinical data , cortical excitbility
Diagnostic Test: Cortical excitability using transcranial magnetic stimulation
Genetic analysis, clinical data , cortical excitbility
Diagnostic Test: Cortical excitability using transcranial magnetic stimulation
Transcranial magnetic stimulation (TMS) is a noninvasive neurophysiological technique for assessing human motor cortical function. With TMS, the underlying motor cortex is stimulated by an electric current induced by a transient magnetic field, generated in response to the passage of a large current through the stimulating coil located on the patient's scalp.
Score on MDS-UPDRS
Score on MDS-UPDRS
Time frame: through study completion, an average of 1 year
Score on mini mental state examination
Score on mini mental state examination
Time frame: through study completion, an average of 1 year
Score on PDQ-39
Score on PDQ-39
Time frame: through study completion, an average of 1 year
Score on Score on Montreal Cognitive Assessment
Score on Score on Montreal Cognitive Assessment
Time frame: through study completion, an average of 1 year
Plan to share: Undecided
This study is status unknown, as verified in Feb 2023. You cannot join it, but the record below documents what was studied.
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Assiut University