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CompletedNCT05679765Updated Jan 12, 2023

Efficacy of GONB in Patients of Migraine

A Phase 4 interventional study of Greater Occipital Nerve Block with dexamethasone and lidocaine and Greater Occipital Nerve Block with 0.9% saline in Chronic Migraine and Headache, sponsored by Pain Medicine Department. Completed at 1 site in Pakistan. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2023-01-12.

Sponsored by Pain Medicine Department · Phase 4, Interventional, and Treatment

From the registry’s dates

  • Registered 8 months after the study started (first participant enrolled Apr 2022, registered Dec 2022).
Phase
Phase 4
Study type
Interventional
Enrollment
50
Allocation
Randomized
Ages
18 Years to 60 Years
Sex
All
01

Study summary

The study was carried to determine the analgesic efficacy of greater occipital nerve block in patients of migraine. It was a randomised controlled which took place from april 2022 - october 2022. Fifty patients suffering from migraine were included in the study. Patients in Group G were given greater occipital nerve block (GONB) with lignocaine and dexamethasone under ultrasound guidance while those in Group S were given saline 0.9% as placebo. Pain score using Numeric Rating Scale and number of headache days was assessed at four,eight and twelve weeks after the procedure as a primary outcome. Total headache days were recorded as a secondary outcome.

02

Conditions studied

  • Chronic Migraine
  • Headache
03

In context

Migraine Disorders

1,528 studies on the registry are indexed under Migraine Disorders; 299 are open to participants now.

This study's enrollment of 50 is below the median of 80 across 1,175 interventional studies indexed under Migraine Disorders.

Browse Migraine Disorders studies →

Lead sponsor

Pain Medicine Department is the lead sponsor of 2 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 60 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Patients between 18 to 60 years
  • diagnosed case of migraine

Exclusion criteria

Exclusion Criteria:

  • Patients with known allergies to local anaesthetics
  • pregnancy
  • history of cranial or cervical surgery
  • head injury
  • headaches secondary to medication overuse
  • patients with uncontrolled systemic disease like blood pressure, diabetes mellitus
  • hypo or hyperthyroidism
  • patient who had already received GONB or botulinum toxin type A therapy within last 6 months
  • major psychiatric disorder
  • history of chronic pain syndromes
05

Study design

Phase
Phase 4
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Triple (Participant, Care provider, Investigator)
Enrollment
50 participants (actual)

Study arms

  • Experimental
    Group G

    Greater occipital nerve block (GONB) under ultrasound guidance with lidocaine and dexamethasone on the side of headache

    Drug: Greater Occipital Nerve Block with dexamethasone and lidocaine · Drug: Greater Occipital Nerve Block with 0.9% saline

  • Active comparator
    Group S

    Greater occipital nerve block (GONB) under ultrasound guidance on the side of headache with 0.9% Saline (Placebo)

    Drug: Greater Occipital Nerve Block with dexamethasone and lidocaine · Drug: Greater Occipital Nerve Block with 0.9% saline

Interventions

  • DrugGreater Occipital Nerve Block with dexamethasone and lidocaine

    Ultrasound guided Greater occipital nerve block on the side of headache

    Also known as: GONB with dexamethasone and lidocaine

  • DrugGreater Occipital Nerve Block with 0.9% saline

    Ultrasound guided Greater occipital nerve block on the side of headache

    Also known as: GONB with 0.9% saline

06

What researchers measure

Primary outcomes

  1. Analgesic efficacy

    Change in Pain score assessed on Numeric Rating Scale (NRS) which ranges from 0 to 10. 0 is no pain and 10 is maximum pain.

    Time frame: 12 weeks

Secondary outcomes

  1. Headache days

    Number of headache days over the course of study period.

    Time frame: 12 weeks

07

Study locations

1 site
  • Pain Medicine Department
    Lahore, Pakistan
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 12, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT05679765
Lead sponsor
Pain Medicine Department
Responsible party
Moazzam Ali (Doctor, Head Of Department, Pain Medicine Department) — Principal investigator
First posted
Jan 11, 2023
Start date
Apr 1, 2022
Primary completion
Aug 31, 2022
Completion
Aug 31, 2022
Last update
Jan 12, 2023

Study contacts

Moazzam Ali
principal investigator · Pain Medicine Department

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Jan 2023. You cannot join it, but the record below documents what was studied.

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