An interventional study of Hyaluronidase and Bupivacaine Injection in Pain, Postoperative, sponsored by Benha University. Completed at 1 site in Egypt. Open to female participants aged 18 Years to 40 Years. Per ClinicalTrials.gov, last updated 2025-09-19.
Sponsored by Benha University · Not applicable, Interventional, and Prevention
Since TAP block needs to affect several nerves in single tissue plane with a single prick, hyaluronidase is expected to aid greatly in the spread of the LA and help the block. However, there have not been adequate studies to establish the efficacy of adding hyaluronidase in lateral TAP after cesarean section. Hence, the present study was carried out to evaluate the efficacy of hyaluronidase in different concentrations added to bupivacaine in US-guided bilateral lateral TAP block.
5,093 studies on the registry are indexed under Pain, Postoperative; 1,140 are open to participants now.
This study's enrollment of 114 is above the median of 75 across 4,344 interventional studies indexed under Pain, Postoperative.
Browse Pain, Postoperative studies →Benha University is the lead sponsor of 356 studies on the registry; 68 are open to participants now.
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Exclusion Criteria:
patients will received TAB block with 19 ml bupivacaine 0.25 % plus 1 ml 0.9% normal saline containing 750 IU hyaluronidase as an adjuvant in each side after closing skin.
Drug: Hyaluronidase
patients will received TAB block with 19 ml bupivacaine 0.25 % plus 1 ml 0.9% normal saline containing 1500 IU hyaluronidase as an adjuvant in each side after closing skin.
Drug: Hyaluronidase
patients will received TAB block with 19 ml bupivacaine 0.25 % plus 1 ml 0.9% normal saline without any adjuvant in each side after closing skin.
Drug: Bupivacaine Injection
hyaluronidase will be applied as adjuvant to bupivacaine in transversus abdominis plane block to enhance the postoperative analgesic effect after CS
20ml bupivacaine will be injected without additives in the transversus abdominis plane block on each side for postoperative analgesic after CS
the duration of analgesia
the interval between performing the block and the time of the first request for analgesia.
Time frame: 24 hours postoperative
the postoperative pain severity
pain was assessed by the visual analog scale (VAS) pain score (range, 0-10; 0, no pain; 10, worst pain)
Time frame: every 0,2,4,8,12, up to 24 hours postoperative
total morphine consumption
Time frame: at 24 hours postoperatively
patient satisfaction
assessed on a four-point scale (1, excellent; 2, good; 3, fair; 4, poor)
Time frame: at 24 hours postoperatively
Plan to share: No
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This study is completed, as verified in Sep 2025. You cannot join it, but the record below documents what was studied.
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Benha University