An interventional study of Transcranial stimulation over the cerebellar hemispheres in Ataxia, Spinocerebellar Ataxias and Multiple System Atrophy, sponsored by Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia. Completed at 1 site in Italy. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2022-12-27.
Sponsored by Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · Not applicable, Interventional, and Treatment
Among 10 studies in Spinocerebellar Ataxias with a site in Italy — 1 open to participants now, 4 under way, 1 of them phase 3. Spinocerebellar Ataxias · Italy.
Among the 10 studies in Spinocerebellar Ataxias with a site in Italy, this one is the only one that started in 2021, is one of 5 with no phase, and was the 6th registered.
94 studies on the registry are indexed under Spinocerebellar Ataxias; 24 are open to participants now.
Browse Spinocerebellar Ataxias studies →1 of the 10 studies in Spinocerebellar Ataxias with a site in Italy is open now. Recruiting first, the newest first:
Ataxia Study Group · Sites in Italy, Austria, Belgium and 7 more countries
A study can be open while its sites in Italy have not opened yet or have stopped. Only those recruiting at a site in Italy →
Of the 16 Spinocerebellar Ataxias studies recruiting now, 8 (50%) set no upper age limit and 3 (19%) stop at 75 or younger; 4 take children under 18; 5 take healthy volunteers.
This study: 18 Years and older · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
10 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 1 · Phase 2 2 · Phase 3 2
First in 2005; this study’s year is marked. 1 started in 2021.
This study's enrollment of 26 is below the median of 31 across 60 interventional studies indexed under Spinocerebellar Ataxias.
Median enrollment 26 across the 9 interventional studies, 400 across the 1 observational. Of the 6 that completed or were terminated, 1 (17%) have results posted.
This tab as a report to print or save as PDF → With an account.
2 of 10 have an industry lead sponsor. The 7 most frequent:
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia is the lead sponsor of 84 studies on the registry; 15 are open to participants now.
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia has 3 studies filed under Spinocerebellar Ataxias — fewer than ten, so there is no comparison to draw.
1 of the studies in Spinocerebellar Ataxias with a site in Italy that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT06672445Arrowhead PharmaceuticalsStudy of ARO-ATXN2 Injection in Adults With Spinocerebellar Ataxia Type 2 | 2026-12 |
Among the 10 studies in Spinocerebellar Ataxias with a site in Italy, from their registry updates:
This tab as a report to print or save as PDF → With an account.
The aim of the study is to evaluate the effects on motor and cognitive performance of transcranial alternating current stimulation (tACS) compared to transcranial direct current stimulation (tDCS) and placebo stimulation (sham) in patients with neurodegenerative ataxia to identify a possible rehabilitation protocol.
94 studies on the registry are indexed under Spinocerebellar Ataxias; 24 are open to participants now.
This study's enrollment of 26 is below the median of 31 across 60 interventional studies indexed under Spinocerebellar Ataxias.
Browse Spinocerebellar Ataxias studies →Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia is the lead sponsor of 84 studies on the registry; 15 are open to participants now.
Compared within Spinocerebellar Ataxias, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Ataxia. The counts are of registry records indexed under each term, refreshed daily. How we classify →
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Single session of anodal tDCS at 2 mA over the cerebellar hemispheres
Device: Transcranial stimulation over the cerebellar hemispheres
Single session of gamma tACS (50 Hz) at 3 mA over the cerebellar hemispheres
Device: Transcranial stimulation over the cerebellar hemispheres
Single session of sham tDCS over the cerebellar hemispheres
Device: Transcranial stimulation over the cerebellar hemispheres
Single session of Transcranial stimulation over the cerebellar hemispheres
Change in the International Cooperative Ataxia Rating Scale (ICARS) Score From Baseline
International Cooperative Ataxia Rating Scale (ICARS): semi-quantitative 100-point scale, yielding a total score of 0 (no ataxia) to 100 (most severe ataxia).
Time frame: Baseline (immediately before the intervention) - Immediately after the intervention
Change in the Scale for the Assessment and Rating of Ataxia (SARA) Score From Baseline
Scale for the Assessment and Rating of Ataxia (SARA): 8-item performance based scale, yielding a total score of 0 (no ataxia) to 40 (most severe ataxia).
Time frame: Baseline (immediately before the intervention) - Immediately after the intervention
Change in Cerebellar Brain Inhibition (CBI) Measurements From Baseline
Cerebellar brain inhibition (CBI) is expressed as motor evoked potential amplitude (average of 10 recordings). Lower values reflect higher inhibition and thus reduced impairment.
Time frame: Baseline (immediately before the intervention) - Immediately after the intervention
Change in Timed Up and Go Test Duration From Baseline
Time (in seconds) that a person takes to rise from a chair, walk three meters, turn around 180 degrees, walk back to the chair, and sit down while turning 180 degrees, assessed with gait sensors.
Time frame: Baseline (immediately before the intervention) - Immediately after the intervention
Change in Walking Cadence From Baseline
Average Left and Right Steps/Minute during a 60 seconds walk, assessed with gait sensors.
Time frame: Baseline (immediately before the intervention) - Immediately after the intervention
Change in 360° Turn From Baseline
Velocity (Number of Degrees/sec) in making a 360° turn, assessed with gait sensors
Time frame: Baseline (immediately before the intervention) - Immediately after the intervention
Plan to share: No
Ran from Jan 2021 to primary completion in Dec 2022, 22 months.
Of 28 interventional studies with no phase under Spinocerebellar Ataxias, half reached primary completion within 21 months of starting (the median), counting those still running; a quarter within 7 and three quarters within 30. This study's 22 months is close to that.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Dec 2022. You cannot join it, but the record below documents what was studied.
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Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia