ClinicalTrials.gg
CompletedNCT05614791Updated Nov 21, 2024

Evaluation of Pediatric Measles Cases in 2019: Single-Center Experience

An observational study in Measles, sponsored by Marmara University. Completed at 2 sites in Turkey. Open to participants aged 1 Month to 18 Years. Per ClinicalTrials.gov, last updated 2024-11-21.

Sponsored by Marmara University · Observational

Study type
Observational
Model
Case-control
Time perspective
Retrospective
Enrollment
40
Ages
1 Month to 18 Years
Sex
All
01

Study summary

Measles, can be prevented and eliminated by vaccination, is a highly contagious viral disease that can lead to serious complications, disability, and death. As a result of the World Health Organization (WHO) and United Nations International Children's Emergency Fund (UNICEF) strategic plans, the annual global incidence of measles decreased by 75% over the period 2000-2015, and the estimated global mortality rate fell by 73%. For the current 2019 period, the European and the Eastern Mediterranean Region has recorded respectively more than two-fold and 1.5-fold increase in reported measles cases. As it is known, no specific antiviral treatment exists for the measles virus therefore, vaccination is still the most effective method of preventing disease.

The aim of this study was to evaluate the measles cases in districts where the refugees live quite intensely.

Read the detailed description

Measles, can be prevented and eliminated by vaccination, is a highly contagious viral disease that can lead to serious complications, disability, and death. As a result of the World Health Organization (WHO) and United Nations International Children's Emergency Fund (UNICEF) strategic plans, the annual global incidence of measles decreased by 75% over the period 2000-2015, and the estimated global mortality rate fell by 73%. For the current 2019 period, the European and the Eastern Mediterranean Region has recorded respectively more than two-fold and 1.5-fold increase in reported measles cases. As it is known, no specific antiviral treatment exists for the measles virus therefore, vaccination is still the most effective method of preventing disease.

The aim of this study was to evaluate the measles cases in districts where the refugees live quite intensely.

This retrospective study was consecutively enrolled children who were considered as suspicious measles case according to with clinical features and attended in Esenler Gynecology and Pediatrics Hospital Pediatric Clinic between 01 January-30 June 2019.

02

Conditions studied

  • Measles

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Keywords

  • Measles
  • Vaccine
  • Children
  • Vitamin A
03

In context

Measles

134 studies on the registry are indexed under Measles; 17 are open to participants now.

This study's enrollment of 40 is below the median of 282 across 26 observational studies indexed under Measles.

Browse Measles studies →

Lead sponsor

Marmara University is the lead sponsor of 599 studies on the registry; 138 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
1 Month to 18 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Measles case according to with clinical features and attended Pediatric Clinic between 01 January-30 June 2019

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • The suspicious case of measles
  • Measles/Rubella Case Notification and Laboratory request and result form and Measles/ Rubella Case Study form must be filled
  • Accept the form
  • Positive Measles Ig M and Measles Ig G laboratory test

Exclusion criteria

Exclusion Criteria:

  • Rejected the form
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

05

Study design

Observational model
Case-control
Time perspective
Retrospective
Enrollment
40 participants (actual)
Patient registry
No
06

What researchers measure

Primary outcomes

  1. Evaluate the effect of measles vaccination status on symptom duration

    compare the groups symptom durations (day) who fully, partly or not vaccinated

    Time frame: baseline

  2. Evaluate the effect of vitamin A treatment on symptom duration

    compare the groups symptom durations (day) who get or not get vitamin A treatment

    Time frame: in the first month after the first symptom observed

Secondary outcomes

  1. Evaluate the effect of measles vaccination status on leucocyte count

    compare the groups leucocyte count who fully, partly or not vaccinated

    Time frame: baseline

  2. Evaluate the effect of vitamin A treatment on leucocyte count

    compare the groups leucocyte count who get or not get vitamin A treatment

    Time frame: baseline

Other outcomes

  1. Evaluate the effect of measles vaccination status on cost of measles cases

    compare the groups costs (Turkish Lira) who fully, partly or not vaccinated

    Time frame: in the first month after the first symptom observed

  2. Evaluate the effect of vitamin A treatment on cost of measles cases

    compare the groups costs (Turkish Lira) who get or not get vitamin A treatment

    Time frame: in the first month after the first symptom observed

07

Study locations

2 sites
  • Esenler Maternity and Child Health Hospital
    Istanbul, Esenler 34230, Turkey
  • Haseki Training and Research Hospital
    Istanbul, Turkey
08

References and documents

Publications

  • Lord H, Kok J, Fletcher S, Alexander K. Is it or is it not? Lessons learned from a case of suspected vaccine strain measles. Aust N Z J Public Health. 2020 Apr;44(2):160-162. doi: 10.1111/1753-6405.12969. Epub 2020 Mar 19. PubMed 32190947 ↗
  • Lo Vecchio A, Krzysztofiak A, Montagnani C, Valentini P, Rossi N, Garazzino S, Raffaldi I, Di Gangi M, Esposito S, Vecchi B, Melzi ML, Lanari M, Zavarise G, Bosis S, Valenzise M, Cazzato S, Sacco M, Govoni MR, Mozzo E, Cambriglia MD, Bruzzese E, Di Camillo C, Pata D, Graziosi A, Sala D, Magurano F, Villani A, Guarino A, Galli L; SITIP Measles Study Group. Complications and risk factors for severe outcome in children with measles. Arch Dis Child. 2020 Sep;105(9):896-899. doi: 10.1136/archdischild-2018-315290. Epub 2019 Jan 12. PubMed 30636224 ↗
  • Filia A, Bella A, Del Manso M, Baggieri M, Magurano F, Rota MC. Ongoing outbreak with well over 4,000 measles cases in Italy from January to end August 2017 - what is making elimination so difficult? Euro Surveill. 2017 Sep 14;22(37):30614. doi: 10.2807/1560-7917.ES.2017.22.37.30614. PubMed 28933342 ↗

Individual participant data

Plan to share: Undecided — Availability of data and material: When needed, all data can be shared with the consent of the participants.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Nov 21, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05614791
Lead sponsor
Marmara University
Responsible party
mahmut caner us (M.D, Marmara University) — Principal investigator
First posted
Nov 14, 2022
Start date
Jan 1, 2019
Primary completion
Jun 30, 2019
Completion
May 30, 2020
Last update
Nov 21, 2024

Study contacts

Mahmut Caner US, MD
principal investigator · haseki Education and Research Hospital

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Nov 2022. You cannot join it, but the record below documents what was studied.

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